Sergio Farina

Shortened axi-cel manufacturing drives rapid in vivo expansion and shifts the acute toxicity profile in R/R LBCL

Brydon Panozzo, Matthew Rubic, Jian Li, Catelyn Cashion et autres

au (code pays fourni par la source)

Real-world outcomes with CAR T-cell therapy for secondary central nervous system lymphoma are similar between patients with active versus historical involvement

Catelyn Cashion, Jian Li, Sergio Farina, Shafqat Inam et autres

Abstract Background: Secondary central nervous system large B-cell lymphoma (sCNSL) carriers a poor prognosis and is often refractory to standard chemoimmunotherapy. Autologous anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy has revolutionised the treatment of relapsed and/or refractory large B-cell lymphoma (LBCL) but …

au, us (code pays fourni par la source)

Multi-centre real-world outcome of patients with Richter transformation receiving CD19-directed commercial CAR T-cell therapy in Australia.

Jian Li, Mark R. Dowling, Anthony Jeffrey, Sergio Farina et autres

Abstract Aim: Richter transformation (RT) is an uncommon (2-10%) complication of chronic lymphocytic leukemia (CLL), most frequently manifesting as diffuse large B-cell lymphoma (RT-DLBCL, 90-95%). It is associated with complex genetic aberrations and poor prognosis, with a median overall survival (OS) of …

au, us (code pays fourni par la source)

The clinical features, management and outcomes of lymphoma in pregnancy: A multicentre study by the Australasian Lymphoma Alliance

Pietro R Di Ciaccio, Georgia Mills, Michael Shipton, Belinda A. Campbell et autres

Lymphoma in pregnancy (LIP) presents unique clinical, social and ethical challenges; however, the evidence regarding this clinical scenario is limited. We conducted a multicentre retrospective observational study reporting on the features, management, and outcomes of LIP in patients diagnosed between January 2009 …

au, nz (code pays fourni par la source)

Subsegmental pulmonary embolism and anticoagulant therapy: the impact of clinical context

Ariel Dahan, Sergio Farina, Natasha E. Holmes, Stefan R. Kachel et autres

BACKGROUND: Anticoagulation for subsegmental pulmonary embolism (SSPE) is controversial. AIM: To assess the impact of clinical context on anticoagulation and outcomes of SSPE. METHODS: We electronically searched computed tomography pulmonary angiogram reports to identify SSPE. We extracted demographic, risk factor, investigations and …

au (code pays fourni par la source)