Takumi Lee

Risk factors for persistent decline in eGFR of Japanese patients with diabetes: Analysis using a large‐scale diabetes registry J‐ DREAMS

Kota Yamada, Mitsuru Ohsugi, Yuichiro Ito, Hiroki Uchida et autres

AIMS/INTRODUCTION: This study aimed to identify clinical predictors associated with sustained decline in estimated glomerular filtration rate (eGFR) among Japanese individuals diagnosed with diabetes mellitus. MATERIALS AND METHODS: We conducted a retrospective analysis using J-DREAMS (Japan Diabetes compREhensive database project based on …

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Diabetic Ketoacidosis and Severe Hypoglycemia Risks with Ipragliflozin/Insulin Versus Insulin in Type 1 Diabetes: A Japanese Real-World Database Study

Tomoyuki Kawamura, Takumi Lee, Mami Shintani‐Tachi, Izuru Terada et autres

INTRODUCTION: Ipragliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor approved in Japan as an adjunct to insulin therapy for the management of type 1 diabetes (T1D). Diabetic ketoacidosis (DKA) and severe hypoglycemia (SH) have been specified as important identified risks for ipragliflozin; …

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A Phase 2 study of sequential administration of gilteritinib after MEC chemotherapy in Relapsed/Refractory FLT3-mutated Acute Myeloid Leukemia in adults: Japan adult leukemia study group (JALSG) RR-FLT3-AML220 study

Yuichi Ishikawa, Takahiro Yamauchi, Masashi Sawa, Tomomi Toubai et autres

Abstract Introduction: The prognosis of newly diagnosed FLT3-mutated adult acute myeloid leukemia (AML) has recently improved by the combination of standard chemotherapy with FLT3 inhibitors, midostaurin or quizartinib. Nevertheless, once the disease relapses or if the disease is primarily refractory, the prognosis …

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Treatment, perceptions and burden of vasomotor symptoms among midlife women in Japan

Masakazu Terauchi, Marina Kato, Takumi Lee, Takashi Miki et autres

OBJECTIVE: This study aimed to investigate the association between the severity of vasomotor symptoms (VMS) and the burden of the condition in the real-world setting within Japan. METHODS: The cross-sectional survey study was administered as a web-based questionnaire involving perimenopausal and postmenopausal …

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Physician and Patient Preferences for the Treatment of Metastatic Castration-Sensitive and Castration-Resistant Prostate Cancer: A Best-Worst Scaling Study in Japan

Takahiro Kimura, Noriko Takahashi, Keiko Asakawa, Atsushi Saito et autres

INTRODUCTION: Despite many prostate cancer (PC) treatment options in Japan, physicians' and patients' preferences in metastatic castration-sensitive PC (mCSPC) and castration-resistant PC (CRPC) are unclear. METHODS: For this cross-sectional study, an online questionnaire survey based on the best-worst scaling (profile case) approach …

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Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus

Kota Yamada, Mitsuru Ohsugi, Yuichiro Ito, Hiroki Uchida et autres

AIMS/INTRODUCTION: This study aimed to investigate the risk factors for diabetic retinopathy (DR) and diabetic kidney disease (DKD) in Japanese patients with diabetes mellitus (DM). Identifying these factors could provide insights into the shared and distinct mechanisms contributing to these complications in …

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A retrospective study of prognostic factors and prostate-specific antigen dynamics in Japanese patients with metastatic hormone-sensitive prostate cancer who received combined androgen blockade therapy with bicalutamide

Yu Tashiro, Shusuke Akamatsu, Kentaro Ueno, Toshiyuki Kamoto et autres

BACKGROUND: This retrospective observational study explored the therapeutic potential of combined androgen blockade (CAB) with bicalutamide (Bic-CAB) as an initial treatment for metastatic hormone-sensitive prostate cancer (mHSPC) in Japan. METHODS: The electronic health records of 159 patients with mHSPC from three Japanese …

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Physician and Patient Preferences for Treatment of Anemia Associated with Chronic Kidney Disease in Japan: A Survey Including Best-Worst Scaling

Sari Mishina, Yuichiro Ito, Takumi Lee, Toshiaki Murofushi et autres

Background: Several treatment options are available for anemia associated with chronic kidney disease (CKD); however, there remains a lack of awareness of physician and patient preferences regarding these treatments. We aimed to explore physicians' and patients' perceptions and preferences regarding the management …

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Comparative effectiveness of sodium‐glucose co‐transporter‐2 inhibitors and dipeptidyl peptidase‐4 inhibitors on liver function in patients with type 2 diabetes in Japan: A real‐world data analysis

Hirokazu Takahashi, Keiko Asakawa, Yoshinori Kosakai, Takumi Lee et autres

AIM: To compare the effects of sodium-glucose co-transporter-2 inhibitors (SGLT2is) versus dipeptidyl peptidase-4 inhibitors (DPP4is) on liver function in patients with type 2 diabetes (T2D) in Japan. MATERIALS AND METHODS: This was a Japanese retrospective cohort study using the RWD Database (1 …

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Author response for "Comparative effectiveness of sodium‐glucose co‐transporter‐2 inhibitors and dipeptidyl peptidase‐4 inhibitors on liver function in patients with type 2 diabetes in Japan: A real‐world data analysis"

Hirokazu Takahashi, Keiko Asakawa, Yoshinori Kosakai, Takumi Lee et autres

Long‐term prolonged‐release tacrolimus outcomes in living donor kidney transplantation: The Japan Academic Consortium of Kidney Transplantation study‐II

Masayoshi Okumi, Kazuya Omoto, Tomokazu Shimizu, Hiroki Shirakawa et autres

OBJECTIVES: To evaluate the 10-year efficacy and safety of a prolonged-release tacrolimus-based combination immunosuppressive regimen on longer-term outcomes in living donor kidney transplantation. METHODS: Data from Japanese living donor kidney transplant recipients (n = 410) maintained on continuous prolonged-release tacrolimus-based immunosuppression from …

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Interim results from a postmarketing surveillance study of patients with FLT3-mutated relapsed/refractory AML treated with the FLT3 inhibitor gilteritinib in Japan

Haruko Sugamori, Takumi Lee, Takeshi Mitomi, Chika Yamagishi

OBJECTIVE: Gilteritinib received approval for the treatment of FLT3-mutated relapsed or refractory acute myeloid leukemia in Japan in 2018. In accordance with regulatory requirements, we conducted a multicenter, observational surveillance of gilteritinib use in Japan. METHODS: Patients were followed for 6 months …

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