Accès ouvert
2026
article
OpenAlex
Denisa Bojková, Katja Steinhorst, Marco Bechtel, Nadja Zoeller et autres
SARS-CoV-2 RNA contains guanine-rich sequences that form secondary structures known as G quadruplexes (G4s). The SARS-CoV-2 nonstructural protein (NSP13) resolves G4s due to its helicase and ATPase activity, a process essential for viral replication. Here, we tested the effects of synthetic G4s …
de, gb
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Accès ouvert
2025
article
OpenAlex
Philipp Reus, Emma Torbica, Tamara Rothenburger, Marco Bechtel et autres
Papaverine (PV) has been previously identified as a promising candidate in SARS-CoV-2 repurposing screens. In this study, we further investigated both its antiviral and immunomodulatory properties. PV displayed antiviral efficacy against SARS-CoV-2 and influenza A viruses H1N1 and H5N1 in single infection …
de
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Accès ouvert
2024
preprint
OpenAlex
Philipp Reus, Emma Torbica, Tamara Rothenburger, Marco Bechtel et autres
Papaverine (PV) has been previously identified as a promising candidate in SARS-CoV-2 repurposing screens. In this study, we further investigated both its antiviral and immunomodulatory properties. PV displayed antiviral efficacy against SARS-CoV-2 and influenza A virus (IAV) H1N1 and H5N1 in single …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Jindrich Jr. Cinatl, Marco Bechtel, Philipp Reus, Mélanie Ott et autres
The Mpox virus can cause severe disease in the susceptible population with dermatologic and systemic manifestations. Furthermore, ophthalmic manifestations of mpox infection are well documented. Topical trifluridine (TFT) eye drops have been used for therapy of ophthalmic mpox infection in patients, however, …
de, gb
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Accès ouvert
2023
article
OpenAlex
Denisa Bojková, Nadja Nicole Zöller, Manuela Tietgen, Katja Steinhorst et autres
The antiviral drugs tecovirimat, brincidofovir, and cidofovir are considered for mpox (monkeypox) treatment despite a lack of clinical evidence. Moreover, their use is affected by toxic side-effects (brincidofovir, cidofovir), limited availability (tecovirimat), and potentially by resistance formation. Hence, additional, readily available drugs …
de, gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Denisa Bojková, Marco Bechtel, Tamara Rothenburger, Joshua D. Kandler et autres
Recent findings in permanent cell lines suggested that SARS-CoV-2 Omicron BA.1 induces a stronger interferon response than Delta. Here, we show that BA.1 and BA.5 but not Delta induce an antiviral state in air-liquid interface cultures of primary human bronchial epithelial cells …
de, gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Patrick Carius, Annemarie Jungmann, Marco Bechtel, Alexander Grißmer et autres
Abstract In the development of orally inhaled drug products preclinical animal models regularly fail to predict pharmacological as well as toxicological responses in humans. Models based on human cells and tissues are potential alternatives to animal experimentation allowing for the isolation of …
de
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Accès ouvert
2023
article
OpenAlex
Denisa Bojková, Philipp Reus, Leona Panosch, Marco Bechtel et autres
Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a readout for monitoring the replication of SARS-CoV-2 isolates from different variants, including a remdesivir-resistant strain, and of other coronaviruses in numerous …
de, gb
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Denisa Bojková, Nadja Nicole Zöller, Manuela Tietgen, Katja Steinhorst et autres
Abstract The antiviral drugs tecovirimat, brincidofovir, and cidofovir are considered for mpox (monkeypox) treatment despite a lack of clinical evidence. Moreover, their use is affected by toxic side-effects (brincidofovir, cidofovir), limited availability (tecovirimat), and potentially by resistance formation. Hence, additional, readily available …
de, gb
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Denisa Bojková, Marco Bechtel, Tamara Rothenburger, Katja Steinhorst et autres
suggest an increased incidence of ectopic pregnancy detected after abortion with the use of no-touch protocols. 5However, clinicians must maintain a high index of suspicion for ectopic pregnancy in persons presenting with suggestive symptoms, in particular in persons without confirmation of an …
de, gb
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Denisa Bojková, Marco Bechtel, Tamara Rothenburger, Joshua D. Kandler et autres
Abstract Recent findings in permanent cell lines suggested that SARS-CoV-2 Omicron BA.1 induces a stronger interferon response than Delta. Here, we show that BA.1 and BA.5 but not Delta induce an antiviral state in air-liquid interface (ALI) cultures of primary human bronchial …
de, gb
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Rebekka Karlowitz, Megan Lynn Stanifer, Jens Roedig, Geoffroy Andrieux et autres
Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Type III IFNs (IFN-λ) exhibit cell-type specific and long-lasting functions in auto-inflammation, tumorigenesis, and antiviral defense. Here, we identify the deubiquitinating …
de, us
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