Muhammad Hassan Butt

EFFICACY OF INTRACORONARY ADENOSINE AND VERAPAMIL IN NO-REFLOW AMONG NORMOTENSIVE PATIENTS PRESENTING WITH ACUTE CORONARY SYNDROME

Altaf Hussain, Muhammad Hassan Butt, Altaf Hussain Gajoo, Muhammad Khan Soomro et autres

Objective:To compare the efficacy of intracoronary adenosine and verapamil in improving myocardial perfusion in normotensive patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).Study Design:This was a prospective observational study.Place and Duration:This study was conducted at Chandka Medical College Hospital …

TO COMPARE THE CLINICAL OUTCOMES OF NONOSTIAL AND OSTIAL LAD LESIONS IN PATIENTS HAVING ACUTE AWMI UNDERGOING PPCI

Ahmed Ali Phulpoto, Jaghat Ram, Muhammad Hassan Butt, Muhammad Ismail et autres

"Background: Globally, one of the leading causes of mortality and morbidity include cardiovascular diseases (CVD). Plaque disruption results in acute thrombotic coronary events, which leads to occlusion of blood flow to a portion of the myocardium. Acute anterior wall myocardial infarction (AWMI) …

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Computational Profiling of Asteraceae‐Derived Phytochemicals Targeting S‐Adenosylhomocysteine Hydrolase (SAHH) of Naegleria fowleri

Hira Khalid, Iqra Ahmad, Muhammad Hassan Butt, Amen Shamim et autres

Abstract Primary amoebic meningoencephalitis (PAM) is a rare but fatal disease caused by Naegleria fowleri ( N. fowleri ). This parasitic amoeba has adverse and deadly effects on humans and animals, as it thrives in fresh and warm water environments and has …

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Regulatory role of stem-loop structures in Faba bean necrotic yellows virus replication efficiency

Muhammad Ali Amir, Muhammad Hassan Butt, Aamir Lal, Thuy Thi Bich Vo et autres

is a family of multipartite single-stranded DNA (ssDNA) plant viruses that encapsidate approximately 1 kb ssDNA segments individually and transmit them via aphids in a circulative, non-propagative manner. Nanoviruses cause significant diseases in host plants, particularly in leguminous crops. Each segment of …

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Comparative analysis of ACE2 mutations and their impact on SARS-CoV-2 susceptibility within diverse ethnic groups

Rabia Shafique, Ambreen Zahra, Muhammad Hassan Butt, Sultan Habibullah Khan et autres

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has significantly impacted on global public health and economies. Emerging from China, the virus generated diverse variants with varying infectivity and drug resistance profiles. SARS-COV-2 requires an ACE-2 receptor for its adhesion, and and …

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Phytobioinformatics screening of ayurvedic plants for potential α-glucosidase inhibitors in diabetes management

Hira Khalid, Muhammad Hassan Butt, Aziz ur Rehman Aziz, Iqra Ahmad et autres

The enzyme α-glucosidase in the small intestine regulates blood glucose levels and stimulates the hydrolysis of oligosaccharides and polysaccharides, increasing glucose levels in the body. Inhibiting this enzyme slows glucose digestion and absorption and as a result post-prandial blood glucose levels remain …

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Identification of potential inhibitors against Corynebacterium diphtheriae MtrA response regulator protein; an in-silico drug discovery approach

Zunera Khalid, Amen Shamim, Mohamed J. Saadh, Ahmed D. Alafnan et autres

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Integrated Evaluation of Obesity and Smoking as Synergistic Risk Factors for Cardiovascular Complications. A Cross-Sectional Study

Javed Khurshed Shaikh, Tahir Hussain Soomro, Muhammad Hassan Butt, Muhammad Ismail et autres

Background: Obesity and smoking are independently established risk factors for cardiovascular disease (CVD). However, the combined effect of these two variables as synergistic contributors to cardiovascular complications has not been adequately explored in the Pakistani population. Study Design: The aims of study …

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Immediate in-hospital outcomes after percutaneous revascularization of acute myocardial infarction complicated by cardiogenic shock

Bashir Ahmed Solangi, Jehangir Ali Shah, Rajesh Kumar, Mahesh Kumar Batra et autres

BACKGROUND: Cardiogenic shock (CS) is a life-threatening complication of acute myocardial infarction with high morbidity and mortality rates. Primary percutaneous coronary intervention (PCI) has been shown to improve outcomes in patients with CS. AIM: To investigate the immediate mortality rates in patients …

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A Quantitative Investigation of Gender-Related Variations in Coronary Artery Diameters

Imran Ellahi Soomro, Muhammad N. Aslam, Muhammad Amin, Aftab Ahmed et autres

Objective: To evaluate the association between gender and coronary artery diameter at the cardiac ward of a tertiary care hospital. Background: Understanding the normal structure of the coronary arteries is essential for accurately describing the amount of coronary atherosclerosis. However, studies on …

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NONCOMPLIANCE TO TREATMENT AND COMMON PRECIPITATING FACTORS IN STAGE C HEART FAILURE

Jehangir Ali Shah, Bashir Ahmed Solangi, Rajesh Kumar, Gulzar Ali et autres

Objectives: The objective of this study was to determine the frequency of non-compliance to treatment and common precipitating factors in stage C heart failure (HF) patients at a tertiary care cardiac hospital of Karachi, Pakistan. Methodology: This descriptive cross-sectional study was conducted …

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Frequency of Left Ventricular Thrombus after Acute Anterior Wall Myocardial Infarction at Karachi

Fiyaz Hussain Mallah, Muhammad Tariq, Waqar Hussain, Javed Khurshed Shaikh et autres

Background: The left ventricular problem is a prominent acute myocardial infarction (AMI) complication. It has been demonstrated that rapid reperfusion reduces mortality and improves left ventricular (LV) function. There is a dearth of information on left ventricular thrombus (LVT) in the current …

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