Kushan L. Gunawardhana

Integrated transcriptomic and regulatory RNA profiling reflects complex pathophysiology and uncovers a conserved gene signature in end stage heart failure

Amit N. Anand, Julius Punnen, U.M. Nagamalesh, Sabariya Selvam et autres

Background: Heart failure (HF) is a complex syndrome. Despite availability of multiple treatment options, the mortality remains high and the quality of life poor. Better understanding of the underlying pathophysiological processes can lead to development of novel therapies. Multiple comparative transcriptomics studies, …

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Prognostic Significance and Biologic Associations of Senescence‐Associated Secretory Phenotype Biomarkers in Heart Failure

Oday Salman, Payman L. Zamani, Lei Zhao, Marie‐Joe Dib et autres

BACKGROUND: The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using …

us, de, sg, nz, be, jp, nl (code pays fourni par la source)

Proteome-Wide Genetic Investigation of Large Artery Stiffness

Marie‐Joe Dib, Joe David Azzo, Lei Zhao, Oday Salman et autres

The molecular mechanisms contributing to large artery stiffness (LAS) are not fully understood. The aim of this study was to investigate the association between circulating plasma proteins and LAS using complementary proteomic and genomic analyses. A total of 106 proteins associated with …

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SEX DIFFERENCES IN PLASMA PROTEOMICS AND ASSOCIATED CLINICAL OUTCOMES IN HEART FAILURE WITH REDUCED EJECTION FRACTION

Corinne Carland, Joe David Azzo, Lei Zhao, Laura Liu et autres

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Proteomic Correlates of the Urinary Protein/Creatinine Ratio in Heart Failure With Preserved Ejection Fraction

Sushrima Gan, Lei Zhao, Oday Salman, Zhaoqing Wang et autres

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Abstract P392: Prdm6 Is An Embryonic Regulator Of Renin-producing Cells And Its Loss Of Function Causes Hypertension In Humans

Arya Mani, Kushan L. Gunawardhana, Trojan Rugira

Essential hypertension is an inherited disease but its genetic causes are vastly not known. Genome-wide association studies (GWAS) have identified 5q23 as one of the strongest loci for hypertension in numerous populations with diverse ethnic backgrounds. Using massively parallel reporter and gene …

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Impact of diabetes on remodelling, microvascular function and exercise capacity in aortic stenosis

Abhishek Dattani, Emer M. Brady, Aseel Alfuhied, Gaurav Singh Gulsin et autres

Objective To characterise cardiac remodelling, exercise capacity and fibroinflammatory biomarkers in patients with aortic stenosis (AS) with and without diabetes, and assess the impact of diabetes on outcomes. Methods Patients with moderate or severe AS with and without diabetes underwent echocardiography, stress …

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PROTEOMIC ASSOCIATIONS OF N-TERMINAL (NT)-PRO HORMONE BNP (NT-PROBNP) IN HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)

Oday Salman, Lei Zhao, Payman L. Zamani, Jordana B. Cohen et autres

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EFFECT OF SPIRONOLACTONE ON THE PLASMA PROTEOME IN HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF): IMPACT OF BASELINE N-TERMINAL (NT)-PRO B-TYPE NATRIURETIC PEPTIDE (BNP) LEVELS

Oday Salman, Lei Zhao, Payman L. Zamani, Jordana B. Cohen et autres

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A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension

Kushan L. Gunawardhana, Lingjuan Hong, Trojan Rugira, Severin Uebbing et autres

Genetic variants in the third intron of the PRDM6 gene have been associated with BP traits in multiple GWAS. By combining fine mapping, massively parallel reporter assays, and gene editing, we identified super enhancers that drive the expression of PRDM6 and are …

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Abstract 11642: Biologic Associations of the Senescence-Associated Secretory Phenotype (SASP) in Heart Failure (HF): Insights From Plasma Proteomics

Chenao Qian, Payman L. Zamani, Oday Salman, Qasim Jehangir et autres

Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We assessed biologic pathways associated with the SASP in human HF using a plasma proteomics approach. Methods: We measured 25 known …

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Abstract 11559: Prognostic Significance of Senescence-Associated Secretory Phenotype (SASP) Biomarkers in Heart Failure (HF)

Chenao Qian, Payman L. Zamani, Oday Salman, Qasim Jehangir et autres

Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We aimed to assess the prognostic significance of the SASP assessed by a combination of plasma protein biomarkers in human HF. …

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