Fabiola Incandela

Cutting-edge organization: A consensus-informed framework in surgical oncology

Nicola Nicolai, Giorgio Bogani, Roberto Agresti, Riccardo A. Audisio et autres

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Chimeric thoracodorsal free flap reconstruction for extended circumferential pharyngo-laryngectomy: A case report

Valentina Cristofaro, Fabiola Incandela, Lorenzo Giannini, Madia Pompilio et autres

INTRODUCTION: Circumferential pharyngolaryngectomy (CPL) may result in extensive posterior pharyngeal defects for which standard reconstructive strategies are insufficient. Chimeric flaps from the thoracodorsal system (TDSF) offer independently vascularized components that may address both posterior coverage and luminal restoration. We report what appears …

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Evaluation of large language models as decision support tools for head and neck cancer management: A blinded multidisciplinary simulation study

Sholem Hack, Ron J. Karni, Antonino Maniaci, Christopher Fundakowski et autres

• LLMs generated guideline-concordant management recommendations for complex head and neck cancer scenarios. • Retrieval augmentation was associated with higher ratings for appropriateness and feasibility in this blinded simulation. • Eight blinded surgeons rated outputs across appropriateness, clarity, specificity, and feasibility domains. …

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When Should Elective Neck Dissection Be Considered for Early‐Stage Oral Cavity Tumors? Insights From a Multicenter Study of 1109 Patients and Development of a Multiparametric Predictive Model

Luca Calabrese, Monir Abousiam, Marta Tagliabue, Marco Ferrari et autres

BACKGROUND: Nodal metastases significantly affect prognosis in oral cavity squamous cell carcinoma (OCSCC). In early-stage OCSCC (cT1-T2 cN0), management of the clinically negative neck (cN0) remains controversial. Depth of invasion (DOI) is a key determinant for END, but other histopathological parameters, such …

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The Host-index in patients undergoing upfront surgery and free flap reconstruction for head and neck squamous cell carcinoma

Valentina Cristofaro, Lorenzo Giannini, Andrea Alliata, Francesca Fraccaroli et autres

Objective: The Host-index (H-index) is a value obtained using blood laboratory parameters. Elevated H-index is a negative prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of our study was to assess the prognostic impact of the …

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Radiation-Induced Oropharyngeal Squamous Cell Carcinoma: Case Report and Review of the Literature

Lorenzo Giannini, Andrea Alliata, Valentina Cristofaro, Fabiola Incandela et autres

BACKGROUND: Radiation therapy (RT) is a mainstay for the treatment of head and neck (HN) cancers, with 80% of patients receiving such treatment. Radiation-induced malignancies represent a life-threatening long-term effect of RT, with an incidence of 0.5% to 15%. CASE DESCRIPTION: After …

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Barbed Suspension Pharyngoplasty (BSP)

Marco Barbieri, Davide Mocellin, Francesco Missale, Fabiola Incandela et autres

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Comparison of Different Staging Systems Applied to a Cohort of Patients With Oral Tongue and Floor of the Mouth Cancer

Lorenzo Bresciani, Lorenzo Giannini, Alberto Paderno, Fabiola Incandela et autres

Purpose: The present work compares the effects produced by the application of the 7th edition of the tumor node metastasis (TNM) staging system (TNM7), 8th Edition (TNM8) with its two subsequent revisions, and pN-N+ classification on a cohort of patients with oral …

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Development of Exhaustion and Acquisition of Regulatory Function by Infiltrating CD8+CD28− T Lymphocytes Dictate Clinical Outcome in Head and Neck Cancer

Daniela Fenoglio, Liliana Belgioia, Alessia Parodi, Francesco Missale et autres

Head and neck squamous cell carcinoma (HNSCC) has a poor clinical outcome despite the presence of a rich CD8+ T cell tumor infiltrate in the majority of patients. This may be due to alterations of tumor infiltrating CD8+ T cells. Here, we …

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Head and neck adult-type soft tissues sarcomas: survival analysis and comparison between the last two editions of the TNM staging system

Lorenzo Giannini, Lorenzo Bresciani, Alberto Paderno, Fabiola Incandela et autres

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Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy

Filippo Marchi, Francesco Missale, Claudio Sampieri, Marta Filauro et autres

A picture is emerging in which advanced laryngeal cancers (LCs) are potentially not homogeneous and may be characterized by subpopulations which, if identified, could allow selection of patients amenable to organ preservation treatments in contrast to those to be treated with total …

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Transoral management of adult benign laryngeal stenosis

Fabiola Incandela, Francesco Missale, Francesco Mora, Filippo Marchi et autres

PURPOSE: Management of benign laryngeal stenosis (BLS) remains challenging even though transoral treatments in selected cases have shown satisfactory results, at least comparable to open-neck approaches, with reduced invasiveness. To date, no overall consensus has been reached on many issues. The aim …

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