James R. Mason

Double-Blind Randomized Phase 2 Trial Testing Personal Cancer Vaccines in Patients with Advanced Ovarian Cancer

Lisa N. Abaid, Bradley R. Corr, Ramez N. Eskander, James R. Mason et autres

Background/Objectives: Dendritic cell vaccines are a promising cancer immunotherapy. AV-OVA-1 is a patient-specific vaccine consisting of autologous dendritic cells (DCs) loaded with autologous tumor antigens (ATA) from a lysate of irradiated self-renewing cells enriched for tumor-initiating cells (TICs). A multicenter, double-blind, randomized …

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Enhancing precision in aneurysm volume measurement: A comparative study of techniques including an artificial intelligence-based method for endovascular coiling

Rafael Trindade Tatit, Carlos E. Baccin, Priya Nair, Emmanuel Mensah et autres

Background: Durable occlusion after endovascular coiling can be compromised by recanalization, underscoring the need for accurate cerebral aneurysm assessment. Precise volume measurement not only informs treatment decisions and detects subtle aneurysm growth but also refines calculations of packing density, historically linked to …

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Bone Marrow Harvest: A White Paper of Best Practices by the NMDP Marrow Alliance

Mark A. Murakami, Laura Connelly‐Smith, Thomas R. Spitzer, Adetola A. Kassim et autres

Data on recent bone marrow harvest (BMH) collections from the NMDP has shown that bone marrow (BM) quality has decreased based on total nucleated cell count in the product. To ensure that quality BM products are available to all recipients, the NMDP …

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Detection of Genomic Structural Variations Associated with Drug Sensitivity and Resistance in Acute Leukemia

Darren Finlay, Rabi Murad, Karl Hong, Joyce Lee et autres

Acute leukemia is a particularly problematic collection of hematological cancers, and, while somewhat rare, the survival rate of patients is typically abysmal without bone marrow transplantation. Furthermore, traditional chemotherapies used as standard-of-care for patients cause significant side effects. Understanding the evolution of …

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Long COVID-19 Infections and Organizing Pneumonia in a Series of Patients with Indolent Lymphoma Treated with Rituximab

David G. Savage, Marin Xavier, James R. Mason, Jacqueline Chang et autres

Background: Patients with hematologic malignancies have an increased risk of complications and mortality from COVID-19 (SARS-CoV-2). These patients are often more susceptible to protracted COVID-19 infections (e.g., long COVID-19). In addition, patients treated with the CD20-targeted immunotherapy rituximab in B-cell lymphomas are …

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Treatment-related adverse events in a randomized trial in stage three and four ovarian cancer testing patient-specific dendritic cell vaccines loaded with tumor antigens from self-renewing autologous tumor cells (1258)

Bradley R. Corr, Lisa N. Abaid, James R. Mason, Ramez N. Eskander et autres

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Randomized phase 2 trial of personal dendritic cell (DC)-autologous tumor antigen (ATA) vaccines in newly diagnosed advanced ovary cancer.

Bradley R. Corr, Lisa N. Abaid, James R. Mason, Ramez N. Eskander et autres

5560 Background: Advanced ovarian cancer has a high recurrence rate and poor overall survival (OS). The addition of DC-ATA AV-OVA-1, a personal vaccine consisting of autologous DC pulsed with ATA, was investigated to pursue improving OS. Methods: A multi-center, 2:1 double-blind randomized …

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North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need

Naveen Pemmaraju, Hagop M. Kantarjian, Kendra Sweet, Eunice S. Wang et autres

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with historically poor outcomes and no worldwide consensus treatment approach. Unique among most hematologic malignancies for its frequent cutaneous involvement, BPDCN can also invade other extramedullary compartments, including the central nervous …

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565 Leukapheresis to obtain monocytes to produce dendritic cells for manufacturing AV-OVA-1 personal vaccines in a randomized phase II trial in patients with newly diagnosed advanced ovarian cancer

James R. Mason, Lisa N. Abaid, Bradley R. Corr, Ramez N. Eskander et autres

Background Despite standard therapy, which includes chemotherapy and aggressive surgical debulking, relative 5-year survival for newly diagnosed advanced epithelial ovarian cancer is only 30%. AV-OVA-1 is a personal vaccine consisting of autologous dendritic cells (DC) loaded ex vivo with autologous tumor antigens …

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562 Tumor collection and establishment of tumor-initiating cell cultures to serve as the antigen source for AV-OVA-1 dendritic cell vaccines for patients with newly diagnosed advanced ovarian cancer

Ramez N. Eskander, Lisa N. Abaid, Bradley R. Corr, James R. Mason et autres

Background With standard therapy, which includes chemotherapy and aggressive surgical debulking, relative 5-year survival for newly diagnosed advanced epithelial ovarian cancer is only 30%. AV-OVA-1 is a personal vaccine consisting of autologous dendritic cells (DC) loaded ex vivo with autologous tumor antigens …

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Detection of TP53 Mutation in Acute Myeloid Leukemia by RT-PCR-Based Sanger Sequencing

Emily R. Novak, Anagha Deshpande, Darren Finlay, James R. Mason et autres

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Homeschooled Children are as Safe from Caregiver Abuse as Other Children and May Be Generally Safer: A Response to Dills (2022)

Steven F. Duvall, James R. Mason

After reading Homeschooling and child safety: Are kids safer at home? (Dills, 2022), it was not surprising to find that homeschoolers were as safe from caregiver abuse as students who were under th...

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