Michal Kršek

Osilodrostat

Michal Kršek, Marta Šimůnková

Cushingv syndrom (CS) je onemocnn zpsoben nadmrnou autonomn produkc kortizolu a jeho psobenm na buky, tkn a orgny lidskho tla. Klinick obraz CS je velmi komplexn a bezprostedn ohrouje sv nositele na ivot. Morbidita a mortalita pacient s aktivnm CS je oproti …

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Use of thyroid hormones in euthyroid patients with unexplained fatigue: analyses of aggregate data from European national surveys of professional endocrine society members

Tomasz Bednarczuk, Aleksandra Sugier, Roberto Attanasio, Endre V. Nagy et autres

Background: Managing patients with fatigue is a clinical challenge. Because fatigue is often reported in hypothyroidism, thyroid hormone (TH) therapy may sometimes be incorrectly considered for biochemically euthyroid individuals. This study aimed to evaluate the prevalence and determinants of this practice in …

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The use of thyroid hormones in the treatment of euthyroid patients with treatment-resistant depression. Data from a survey of 5695 European national endocrine professional organization members

Stephen Ludgate, Anne McGowan, Carla Moran, Roberto Attanasio et autres

Purpose: Treatment-resistant depression (TRD) is most commonly defined as depression that has not responded to two different pharmacological agents used for an adequate period of time. We explored the views of European specialists via survey, regarding the use of thyroid hormone (TH) …

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Novel Predictors of Preeclampsia and Pregnancy Complications: the Impact of Type 1 Diabetes Mellitus on Maternal and Fetal Circulatory Levels

Anna Cinkajzlová, Kateřina Anderlová, Markéta Hornová, Antonı́n Pařı́zek et autres

Pregnant women with type 1 diabetes mellitus (T1DM) are at higher risk of complication development in both mothers and their children. The present study aims to describe changes in circulating and umbilical cord concentrations of recently described predictors of pregnancy complications in …

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Tolosa-Hunt syndrome?

Barbora Hola, Michal Kršek, David Netuka, Jiří Soukup et autres

Vitamin D and its clinical applications

Michal Kršek

V článku je uveden přehled současných poznatků o vitaminu D z klinického hlediska. Jsou shrnuta základní fakta o jeho formách, fyziologických účincích a metabolismu. Z klinického hlediska se článek věnuje stavu zásobení vitaminem D, deficitu vitaminu D a jeho klinickým projevům a …

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Ectopic adrenocorticotrophic hormone syndrome in a 10-year-old girl with a thymic neuroendocrine tumor: a case report

Irena Aldhoon-Hainerová, Mikuláš Kosák, Michal Kršek, David Zogala et autres

Thymic neuroendocrine tumor as a cause of Cushing syndrome is extremely rare in children. We report a case of a 10-year-old girl who presented with typical symptoms and signs of hypercortisolemia, including bone fractures, growth retardation, and kidney stones. The patient was …

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Adrenal insufficiency - causes and laboratory diagnosis

Tomas Brutvan, Jana Ježková, Marcela Kotasová, Michal Kršek

Adrenal insufficiency (AI) manifests as a clinical syndrome arising from either the direct impairment of adrenal glands, leading to primary AI characterized by deficiencies in glucocorticoids and mineralocorticoids, or adrenal cortex atrophy due to diminished adrenocorticotropic hormone (ACTH) stimulation, a consequence of …

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EP02.01: Maternal glucose control and fetal growth trajectories in type 1 diabetes

Patrik Šimják, Markéta Hornová, Michal Holub, D. Smetanová et autres

To assess the impact of glucose control on fetal growth patterns in pregnant women with Type 1 diabetes. In this prospective longitudinal study, 95 pregnant women with Type 1 diabetes underwent serial ultrasound biometry in 4-6 weeks intervals from 16 weeks. Glucose …

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Thyroid hormones for euthyroid patients with simple goiter growing over time: a survey of European thyroid specialists

Enrico Papini, Roberto Attanasio, Miloš Žarković, Endre V. Nagy et autres

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Use of levothyroxine for euthyroid, thyroid antibody positive women with infertility: Analyses of aggregate data from a survey of European thyroid specialists (Treatment of Hypothyroidism in Europe by Specialists: An International Survey)

Roberto Negro, Miloš Žarković, Roberto Attanasio, László Hegedüs et autres

OBJECTIVES: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb) is not supported by the available evidence. The aim of the study was to document the use of LT4 by European thyroid …

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Long-term pharmacotherapy of giant prolactinomas

Václav Hána, Manuela Vaněčková, Michal Kršek, Mikuláš Kosák et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)