Robert Davies Inman

Reduction of CXCR3 + CCR6 + CD4 + T Cells and IL ‐17+ RORγt + CD4 + T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

Addison Pacheco, Patricia Pauline M. Remalante-Rayco, Nigil Haroon, Denis Poddubnyy et autres

OBJECTIVE: We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that …

ca (code pays fourni par la source)

FOXO3a Polymorphisms Are Not Associated With Axial Spondyloarthritis or Psoriatic Arthritis Susceptibility in a Canadian Cohort, With Ancestry‐Specific Findings

Addison Pacheco, Proton Rahman, Vinod Chandran, Nigil Haroon et autres

The data that support the findings of this study are available from the corresponding author upon reasonable request.

ca (code pays fourni par la source)

Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis Within a Longitudinal Cohort

Patricia Pauline M. Remalante-Rayco, Laura Passalent, Tina Chim, Hannah Vijayan et autres

OBJECTIVE: The purpose of this study was to estimate the prevalence of difficult-to-manage (D2M) and treatment-refractory (TR) axial spondyloarthritis (axSpA) and to identify factors associated with D2M and TR disease in a longitudinal cohort. METHODS: We performed a cross-sectional analysis on data …

ca, ie, sa (code pays fourni par la source)

Theta-gamma phase-amplitude coupling in the dynamic pain connectome in healthy individuals and abnormalities in people with chronic pain

Ariana Seyed Makki, Kasey Sarah. Hemington, Anton Rogachov, Joshua C. Cheng et autres

The experience of pain arises through the integration of information across brain regions and networks. Theta-gamma phase-amplitude coupling (PAC) reflects interactions between neuronal processes in the brain. We analyzed a previously published dataset to identify PAC of intrinsic brain activity in nociceptive …

ca, us, gb (code pays fourni par la source)

Microfluidic live‐cell imaging of Aspergillus fumigatus and Candida albicans hyphal growth treated with AmBisome and Caspofungin

Darren D. Thomson, Robert Davies Inman, Sharapova NYe, Elaine Bignell

Hyphal forms of human pathogenic fungi cause invasive disease in humans, but the hyphal response to antifungals is understudied. In the major fungal pathogens Aspergillus fumigatus and Candida albicans, we used microfluidic-coupled, fluorescence-mediated live-cell imaging to capture the real-time responses of fungal …

gb (code pays fourni par la source)

Clinical Features and Therapeutic Outcomes in Pyoderma Gangrenosum: A Prospective Cohort Study

David O. Croitoru, Nesrine Brahimi, Haleh Zabihi, Cathryn J. Sibbald et autres

ABSTRACT Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis highly associated with systemic comorbidities. Accurate diagnosis and treatment remain challenging due to its rarity and clinical mimickers. Objectives To evaluate demographic, clinical features and treatment outcomes in patients referred with suspected …

ca, us (code pays fourni par la source)

Achieving inactive disease state in men and women with axial spondyloarthritis: results from a multi-country prospective observational study

Denis Poddubnyy, Joachim Sieper, Servet Akar, Santiago Muñoz‐Fernández et autres

OBJECTIVE: To assess the probability of achieving low disease activity (LDA) and inactive disease (ID) in men vs women with recently diagnosed axial spondyloarthritis (axSpA). METHODS: This 1-year post-hoc analysis of the PROOF study assessed patients with recently diagnosed (≤12 months) axSpA. …

ca, de, tr, es, us (code pays fourni par la source)

Inflammatory bowel disease does not confer higher disease activity or greater radiographic progression in axial spondyloarthritis

Patricia Pauline M. Remalante-Rayco, Yassir Daghistani, Tina Chim, Zeynep Baskurt et autres

OBJECTIVES: To examine whether inflammatory bowel disease (IBD) influences disease activity and radiographic progression in patients with axial spondyloarthritis (axSpA). METHODS: This was a longitudinal cohort study of axSpA patients from a tertiary referral centre. Active axSpA was assessed using the Bath …

ca, sa (code pays fourni par la source)

Multi-omic insights from a multi-ancestry genome-wide meta-analysis of ankylosing spondylitis reveal novel pathways of disease susceptibility

Matthew A. Brown, Zhixiu Li, Xin Wu, Nicholas C. Harvey et autres

gb, cn, es, au, tr, us, nz, ir, ca, fr, kr (code pays fourni par la source)

Anti-Integrin αvβ6 Autoantibodies as a Biomarker for Ulcerative Colitis in Patients with Axial Spondyloarthritis

Enoch Yau, Robert Davies Inman

Objectives An association between axial spondyloarthritis (axSpA) and inflammatory bowel diseases (IBD) has been well described. IgG autoantibodies against the integrin avb6 have been recently identified in the serum of patients with the ulcerative colitis (UC) form of IBD with a high …

ca (code pays fourni par la source)

Residual Disease Activity and Burden of Disease in Canadian Patients With Axial Spondyloarthritis: Results From a Multiregistry Analysis (UNISON-Axial SpA)

D. Choquette, Dafna D. Gladman, Robert Davies Inman, Proton Rahman et autres

OBJECTIVE: There is a key knowledge gap in quantifying residual disease activity in Canadian patients with axial spondyloarthritis (axSpA). The objective of this study was to evaluate and describe residual disease activity and burden of disease in Canadian patients with axSpA. METHODS: …

ca (code pays fourni par la source)

POS0733 DETERMINANTS OF DIFFICULT-TO-MANAGE AXIAL SPONDYLOARTHRITIS: RESULTS FROM A PROSPECTIVE COHORT STUDY

Patricia Pauline M. Remalante-Rayco, Laura Passalent, Mohammed N. Al-Nasser, Tina Chim et autres

Background: The Assessment of SpondyloArthritis international Society (ASAS) group has recently introduced a consensus-based definition for difficult-to-manage (D2M) axial spondyloarthritis (axSpA) to identify patients with active disease despite being treated according to the current standard. This comprehensive definition incorporates not only the …

ca (code pays fourni par la source)