Vahan Aslanyan

Sample sizes for randomized controlled trials utilizing Bayesian response adaptive randomization for continuous outcomes

Vahan Aslanyan, Michelle Nuño, Trevor A. Pickering, Lindsay A. Renfro et autres

We describe a Bayesian approach for sample size estimation for multi-arm randomized controlled trials utilizing response adaptive randomization (RAR) for continuous outcomes. Assuming normally distributed treatment effects and unknown but common treatment variance, this design incorporates outcome data to estimate posterior distributions …

Sample sizes for randomized controlled trials utilizing Bayesian response adaptive randomization for continuous outcomes

Vahan Aslanyan, Michelle Nuño, Trevor A. Pickering, Lindsay A. Renfro et autres

We describe a Bayesian approach for sample size estimation for multi-arm randomized controlled trials utilizing response adaptive randomization (RAR) for continuous outcomes. Assuming normally distributed treatment effects and unknown but common treatment variance, this design incorporates outcome data to estimate posterior distributions …

Sample sizes for randomized controlled trials utilizing Bayesian response adaptive randomization for continuous outcomes

Vahan Aslanyan, Michelle Nuño, Trevor A. Pickering, Lindsay Anne Renfro et autres

We describe a Bayesian approach for sample size estimation for multi-arm randomized controlled trials utilizing response adaptive randomization (RAR) for continuous outcomes. Assuming normally distributed treatment effects and unknown but common treatment variance, this design incorporates outcome data to estimate posterior distributions …

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Relationships between fine memory discrimination and tau burden in two independent cohorts of older adults

Laura E. Fenton, Vahan Aslanyan, Diane M. Jacobs, David P. Salmon et autres

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The effect of APOE4 on Alzheimer’s plasma biomarkers among Mexican Americans in the HABS-HD cohort

Nancy Ortega, Kimberly Espejo, Vahan Aslanyan, Judy Pa

BACKGROUND AND OBJECTIVES: The relationship between APOE4 status and plasma biomarkers previously shown to be related to Alzheimer's risk have not been carefully examined among Mexican Americans. This research is needed to elucidate disparities within the Alzheimer's field by evaluating key genetic …

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Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study

Laura D. Baker, Judy Pa, Jeffrey A. Katula, Vahan Aslanyan et autres

INTRODUCTION: The EXERT study (Exercise in Adults with Mild Memory Problems) was a Phase 3, multicenter, randomized controlled trial that examined effects of exercise on cognition and other measures of brain health in sedentary older adults with amnestic mild cognitive impairment (MCI). …

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Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI

Aladdin H. Shadyab, Vahan Aslanyan, Diane M. Jacobs, David P. Salmon et autres

INTRODUCTION: EXERT was a multisite randomized controlled trial (RCT) examining the effects of moderate-high intensity aerobic training (AX) versus lower-intensity stretching/balance/range of motion (SBR) on cognitive trajectories in older adults with amnestic mild cognitive impairment (aMCI). METHODS: Preplanned post-hoc analyses were conducted …

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Circadian rhythms are associated with higher amyloid-β and tau and poorer cognition in older adults

Joanna L Eckhardt, Lisette Isenberg, Vahan Aslanyan, Teresa K. Monreal et autres

Abstract Several studies implicate circadian rhythm disturbances in Alzheimer’s disease. However, very little is known about how circadian rhythms are associated with Alzheimer’s pathological biomarkers in older adults at early stages of the disease, and how these relationships map onto cognition. This …

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Sex differences in the relationship between physical activity and cognition as mediated by leukocyte telomere length: a UK Biobank study

Nancy Elizabeth Ortega, Vahan Aslanyan, Judy Pa

BACKGROUND: Evaluating sex differences in modifiable risk factors for Alzheimer's disease could provide valuable information regarding the mechanisms by which these factors confer risk. Physical activity is a risk factor that has been shown to positively impact both telomere length, a marker …

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Exploring the Effects of Ethnicity, Sex, and APOE Status on Markers of Inflammation

Joey Annette Contreras, Vahan Aslanyan, Nancy Elizabeth Ortega, Judy Pa

Abstract Background Alzheimer’s Disease (AD) is the most common form of dementia and is considered to disproportionately affect underserved populations like Hispanics/Latinos. Most research available with AD markers such as inflammation and APOE4 has been conducted in predominantly White cohorts, leaving a …

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Characterizing the Effects of APOE4 on AD Risk Markers in Mexican‐Americans

Joey Annette Contreras, Vahan Aslanyan, Kimberly Espejo, Judy Pa

Abstract Background There is a growing need to determine if APOE status infers the same risk for Alzheimer’s disease (AD) in a Hispanic/Latino cohort as it would for a White cohort. To address this, we must first establish the relationship between APOE4 …

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Advanced circadian rhythms in older adults are associated with higher amyloid‐β and tau PET burden and poorer short‐term memory

Joanna L Eckhardt, Anna Lisette Isenberg, Joy Stradford, Vahan Aslanyan et autres

Abstract Background Several studies link circadian rhythm disturbances to Alzheimer's disease. However, little is known about circadian rhythm involvement with Alzheimer’s pathology in early stages of the disease. The current study investigates the relationship between circadian rhythms, Aβ and tau PET, and …

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