Ana Čipak Gašparović

Non-Mammalian Models for Mitochondria Research in CNS Disorders

Dubravka Švob Štrac, Vedrana Filić, Ana Filošević Vujnović, Ivana Vrhovac et autres

Mitochondrial dysfunction is increasingly recognized as a major contributor to central nervous system (CNS) disorders, including neurodegenerative and neuropsychiatric diseases. Animal models are essential for elucidating disease mechanisms and supporting the development of new therapeutic strategies. Among these models, non-mammalian organisms offer …

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Glucose and glicerol regulation of aquaporins and NRF2 expression in breast cancer cell lines

Monika Mlinarić, Ivan Lučić, Ana Josipa Jerončić, Lidija Milković et autres

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Glucose-dependent modulation of aquaporins and its impact on redox signaling in breast cancer cells

Monika Mlinarić, Inês V. da Silva, Graça Soveral, Ana Čipak Gašparović

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Remimazolam and Esketamine for CT-Guided Aortic Graft Infection Drainage in a Patient with Severe Systematic Comorbidities: A Case Report

Katarina Tomulić Brusich, Mia Šestan, Zdravko Jurilj, Ana Čipak Gašparović

Background/Objectives: The management of patients with severe systemic comorbidities undergoing radiologic interventional procedures presents a significant challenge for anesthesiologists. Selecting an appropriate combination of anesthetic drugs is crucial to ensure a safe, painless procedure, facilitate rapid recovery, and minimalize complications. Here, we …

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The Influence of AQP5 on the Response to Hydrogen Peroxide in Breast Cancer Cell Lines

Ivan Lučić, Monika Mlinarić, Ana Čipak Gašparović, Lidija Milković

Breast cancer is a heterogeneous disease with varying responses to therapies. While targeted treatments have advanced, conventional therapies inducing oxidative stress remain widely used. H2O2 has emerged as a therapeutic candidate due to its role in signaling and cell-function regulation. Its transport …

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TCT-304 SGLT2 Inhibitor Empagliflozin Before Coronary Angiography: Can We Reduce Patient Stress?

Katica Cvitkušić Lukenda, Ana Čipak Gašparović, Mirta Milić, Barbara Radovani et autres

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Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer

Inês V. da Silva, Monika Mlinarić, Ana Rita Lourenço, Olivia Pérez-Garcia et autres

Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H2O2), a reactive oxygen …

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Peroxiporins in Triple-Negative Breast Cancer: Biomarker Potential and Therapeutic Perspectives

Anita Bijelić, Tajana Silovski, Monika Mlinarić, Ana Čipak Gašparović

Triple-negative breast cancer (TNBC) remains one of the most challenging subtypes since it is initially characterized by the absence of specific biomarkers and corresponding targeted therapies. Advances in methodology, translational informatics, genomics, and proteomics have significantly contributed to the identification of therapeutic …

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Cellular adaptation to oxidative stress: Insights into peroxiporin function

Monika Mlinarić, Ivan Lučić, Ana Čipak Gašparović

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Peroxiporins: can they modulate cancer resistance?

Monika Mlinarić, Ivan Lučić, Ana Josipa Jerončić, Lidija Milković et autres

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AQP3 and AQP5 Modulation in Response to Prolonged Oxidative Stress in Breast Cancer Cell Lines

Monika Mlinarić, Ivan Lučić, Marko Tomljanović, Ivana Tartaro Bujak et autres

Aquaporins are membrane pores regulating the transport of water, glycerol, and other small molecules across membranes. Among 13 human aquaporins, six have been shown to transport H2O2 and are therefore called peroxiporins. Peroxiporins are implicated in cancer development and progression, partly due …

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Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer

Ana Podolski-Renić, Ana Čipak Gašparović, Andreia Valente, Óscar López et autres

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