Shakila Meshkat

Exploratory safety, tolerability, and feasibility of psilocybin-assisted psychotherapy for adults with co-occurring treatment-resistant depression and cluster B personality disorders

Orly Lipsitz, Ryan M. Brudner, Zoe Doyle, Erica Kaczmarek et autres

Cluster B personality disorders (PDs) are highly comorbid with depression and are associated with attenuated antidepressant response. No clinical trials to date have reported on psilocybin-assisted psychotherapy (PAP) in comorbid treatment-resistant depression (TRD) and PDs. This is the first clinical trial to …

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Efficacy and Safety of Psychedelic Microdosing on Psychological Outcomes in Healthy Adults: A Systematic Review and Meta-analysis

Shakila Meshkat, Marco Leung, Sarina Meshkat, Qiaowei Lin et autres

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Greater Depressive Symptom Severity is Associated with Increased Odds of Analgesic Use

Shakila Meshkat, Qiaowei Lin, Aida Golshan, Venkat Bhat et autres

Introduction: Although pain and depression frequently co-occur, the relationship between depressive symptom severity and both the odds and duration of analgesic use remains underexplored. This study investigated the relationship between depressive symptoms and analgesic use, with particular attention to the duration of …

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Examining the links between COVID-19 seropositivity, metabolic syndrome and depressive symptoms: evidence from ENSANUT 2021–2022

Reinhard Janssen-Aguilar, Qiaowei Lin, Shakila Meshkat, Huda Al-Shamali et autres

Background The COVID-19 pandemic has affected mental health, with a particular impact on depressive symptoms. Metabolic syndrome is also linked to depression, but their combined effects remain unclear. Aims To examine the independent and combined effects of COVID-19 seropositivity and metabolic syndrome …

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Therapeutic Potential of Psilocybin in Psychiatric Disorders: Mechanisms, Efficacy, and Clinical Implications

Shakila Meshkat, Manish K. Jha, Venkat Bhat

Psilocybin, a serotonergic psychedelic, has gained attention as a potential treatment for various psychiatric conditions. In this review, the authors summarize current clinical evidence related to psilocybin's efficacy, safety, and mechanisms of action across psychiatric disorders. Findings from early-phase and small-scale clinical …

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Reciprocal Association Between Endometriosis and Depressive Symptoms: Using Data from NHANES 2005–2006

Hamda Altaf, Qiaowei Lin, Shakila Meshkat, Venkat Bhat et autres

Introduction: Endometriosis, a chronic inflammatory condition affecting approximately 10% of reproductive-aged women, is frequently underdiagnosed and commonly co-occurs with depressive symptoms. However, the nature and directionality of this association remain unclear. Prior work (Hu et al., 2023) has linked depressive symptom severity …

Reimagining psychiatric care with agentic AI: promise, challenges, and a roadmap forward

Divya Sharma, Shakila Meshkat, Argyrios Perivolaris, Mohammad Amin Kamaleddin et autres

Agentic artificial intelligence (AI) represents a pivotal shift in clinical decision support, moving beyond static tools by reasoning, adapting, and acting alongside clinicians. Psychiatry, grounded in subjective experience, trust, and longitudinal care, offers both an opportunity and a high-stakes testbed. Agentic systems …

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Examining the effects of psilocybin-assisted psychotherapy on anhedonia in treatment-resistant depression

Erica Kaczmarek, Nelson B. Rodrigues, Noah Chisamore, Zoe Doyle et autres

Anhedonia, a core symptom of depression, is often resistant to conventional treatments and significantly impacts quality of life. This secondary analysis aimed to evaluate the effects of psilocybin-assisted psychotherapy (PAP) on anhedonia severity in individuals with treatment-resistant depression (TRD). Participants (n = …

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Life stressors and mental health: Depressive symptoms, anxiety, and suicidal ideation or intent during and after the COVID-19 pandemic

Shakila Meshkat, Xiaoxuan Han, Qiaowei Lin, Vanessa K. Tassone et autres

OBJECTIVE: This study aimed to investigate the associations between life stressors and depressive symptoms, anxiety, and suicidal ideation or intent, while also examining how COVID-19 pandemic influenced these associations. METHODS: This study used data from 19,950 participants in the Mental Health Research …

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Magnitude of response in treatment and control groups within psychedelic trials for psychiatric disorders: A meta-analysis

Shakila Meshkat, Qiaowei Lin, Rachel Sousa-Ho, Ilya Demchenko et autres

Abstract Background Psychedelic-assisted psychotherapy has shown potential for psychiatric disorders. However, the magnitude of symptom change in control groups remains poorly understood. We aim to evaluate within-group effects in control groups and compare them to treatment groups in psychedelic trials. Methods A …

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Evaluating the association between caffeine exposure and sleep duration and trouble sleeping in adults

Patrick Viet-Quoc Nguyen, Qiaowei Lin, Shakila Meshkat, Jithin Thekkelkuthiyathottil Joseph et autres

Abstract Study Objectives This study examines whether caffeine is independently associated with sleep outcomes in the general population. Methods Data from the National Health and Nutrition Examination Survey from 2005 to 2018 were analyzed, including adults aged ≥18 years who completed both …

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Stimulant Use and Depressive Symptoms: Associations with Severity, Symptom Clusters, and Substance Type

Shakila Meshkat, Qiaowei Lin, Vanessa K. Tassone, Reinhard Janssen-Aguilar et autres

ABSTRACT Objectives: This study examines how the number and type of stimulants used associates to depressive symptoms, including severity and specific symptom clusters. Methods: Data from the 2005–2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. Stimulant use was classified by …

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