Jessica Diring

Author Reply to Peer Reviews of MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

Julie C. Nielsen, María Benito-Jardón, Noel Christo Petrela, Jessica Diring et autres

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MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

Julie C. Nielsen, María Benito-Jardón, Noel Christo Petrela, Jessica Diring et autres

ABSTRACT Serum response factor (SRF) and its cofactors, Myocardin-related transcription factors A/B (MRTF-A/B), regulate transcription of numerous cytoskeletal structural and regulatory genes, and most MRTF/SRF inactivation phenotypes reflect deficits in cytoskeletal dynamics. We show that MRTF-SRF activity is required for effective proliferation …

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MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

Julie C. Nielsen, María Benito-Jardón, Noel Christo Petrela, Jessica Diring et autres

Serum response factor (SRF) and its cofactors, myocardin-related transcription factors A and B (MRTF-A and MRTF-B, respectively), regulate transcription of numerous cytoskeletal structural and regulatory genes, and most MRTF/SRF inactivation phenotypes reflect deficits in cytoskeletal dynamics. We show that MRTF-SRF activity is …

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IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics

Diane Maurice, Patrick S. Costello, Jessica Diring, Francesco Gualdrini et autres

Abstract Paracrine IL-2 signalling drives the CD8 + T cell expansion and differentiation that allow protection against viral infections, but the underlying molecular events are incompletely understood. Here we show that the transcription factor SRF, a master regulator of cytoskeletal gene expression, …

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Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy

Simona Balestrini, Matthias J. Koepp, Sonia Gandhi, Hannah M. Rickman et autres

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Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken, Karen V. Ambrose, Sam Barrell, Rupert C. L. Beale et autres

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Catherine F. Houlihan, Nina Vora, Thomas Byrne, Dan Lewer et autres

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Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken, Karen V. Ambrose, Sam Barrell, Rupert C. L. Beale et autres

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RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability

Jessica Diring, Stéphane Mouilleron, Neil Q. McDonald, Richard Treisman

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Structure of ArhGAP12 bound to G-Actin

Stéphane Mouilleron, Richard Treisman, Jessica Diring

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

Richard Panayiotou, Francesc Miralles, Rafał Pawłowski, Jessica Diring et autres

The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function …

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Author response: Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

Richard Panayiotou, Francesc Miralles, Rafał Pawłowski, Jessica Diring et autres

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