Julia E. Vallier

A robust and user-agnostic step-emulsion platform for scalable microgel fabrication

Durante Pioche-Lee, Shiyu Yang, Xiaoqian Wang, Yoke Qi Ho et autres

Over the past decade, the integration of microgel-based granular hydrogels in biomedical technologies has experienced substantial growth due to the numerous benefits microgels offer. However, the inability to easily adopt uniform microgel fabrication workflows at scale constitutes a major bottleneck, or in …

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Microfluidics-Enabled Simultaneous Imaging of Neural Activity and Behavior in Chemically Stimulated, Head-Fixed C. elegans

Hyun Jee Lee, Julia E. Vallier, Hang Lu

Abstract Understanding how the brain processes sensory information and produces appropriate behavior is a fundamental question in neuroscience. In this study, we developed a novel microfluidic device that allows for simultaneous observation of neural activity and behavior in Caenorhabditis elegans ( C. …

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VENTURI-BASED MICROFLUIDIC DEVICE FOR SIMULTANEOUS IMAGING OF NEURAL ACTIVITY AND BEHAVIOR IN HEAD-FIXED C. ELEGANS

Hyun Jee Lee, Julia E. Vallier, Hang Lu

Understanding the connection between brain activity and behavior is one of central pursuits in neuroscience.To achieve high-quality neural activity data with minimal motion artifacts in a behaving animal, the animal is often subjected to head-fixation, in which its head is physically secured …

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Microfluidic localized hydrogel polymerization enables simultaneous recording of neural activity and behavior in C. elegans

Hyun Jee Lee, Julia E. Vallier, Hang Lu

, we demonstrate our method's capability to temporarily reconfigure fluid flow and deliver chemical stimuli to the animal's nose to examine the animal's responses. We envision this approach to be useful for similar recordings for other small motile organisms, as well as …

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Selective separation of HFC-32 from R-410A using poly(dimethylsiloxane) and a copolymer of perfluoro(butenyl vinyl ether) and perfluoro(2,2-dimethyl-1,3-dioxole)

Abby N. Harders, Erin R. Sturd, Julia E. Vallier, Whitney R. White et autres

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Selective Separation of Hfc-32 from R-410a Using Poly(Dimethylsiloxane) and a Copolymer of Perfluoro(Butenyl Vinyl Ether) and Perfluoro(2,2-Dimethyl-1,3-Dioxole)

Abby Noelle Harders, Erin R. Sturd, Julia E. Vallier, Whitney R. White et autres