Elber Osorio-Rodríguez

Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved

Alberto Polo-Barranco, Carlos Rebolledo-Maldonado, Dairo Rodelo-Barrios, Juan Solano-Ropero et autres

Elevated plasma lipoprotein(a) [Lp(a)] levels represent a predominantly genetically determined risk factor for atherosclerotic cardiovascular disease and calcific aortic valve disease (CAVD). Mechanistically, Lp(a) transports oxidized phospholipids, lysophosphatidylcholine, and autotaxin, components capable of promoting inflammation, oxidative stress, and valvular fibrocalcific remodeling. This …

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Severe Metabolic Acidosis in Intensive Care: Implications for Acute Kidney Injury, Bicarbonate, and Renal Replacement Therapy

Carlos Rebolledo-Maldonado, Juan Solano-Ropero, Elber Osorio-Rodríguez, Aleyda Parra-Castillo et autres

Severe metabolic acidosis is a frequent finding in the intensive care unit (ICU) and a critical marker of clinical severity and organ dysfunction, closely linked to acute kidney injury (AKI) due to shared physiological mechanisms and the loss of the kidney’s ability …

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Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved

Alberto Polo-Barranco, Carlos Rebolledo-Maldonado, Dairo Rodelo-Barrios, Juan Solano-Ropero et autres

Lipoprotein(a) [Lp(a)] is a predominantly genetic risk factor for atherosclerotic cardiovascular disease and calcified aortic valve disease (CAVD). In addition to its epidemiological and genetic association with aortic stenosis, Lp(a) transports oxidized phospholipids, lysophosphatidylcholine, and autotaxin, components capable of promoting inflammation, oxidative …

Diabetes Mellitus and Lipoprotein(a): A Determinant Interaction in Micro- and Macrovascular Damage

Alberto Polo-Barranco, Carlos Rebolledo-Maldonado, Valeria Esquiaqui-Rangel, Andrea Nuñez-Mejia et autres

Even when people with diabetes mellitus (DM) meet their cholesterol goals, they still face a higher risk of heart and blood vessel problems. One major reason is a particle called lipoprotein(a), or Lp(a), which is similar to LDL cholesterol. Raised levels of …

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Pathogen detection in acellular cerebrospinal fluid: diagnostic insights from a pediatric cohort in Colombia

Jhonny Jesús Patiño Patiño, Elber Osorio-Rodríguez, Yina Paola García Toscano, Margarita Filott-Tamara et autres

ABSTRACT The diagnosis of pediatric meningoencephalitis has traditionally relied on the detection of inflammatory markers in cerebrospinal fluid (CSF), particularly pleocytosis, as an indirect indicator of infection. This assumption presumes that microbial invasion of the central nervous system consistently triggers a measurable …

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Diabetes Mellitus and Lipoprotein(a): A Determinant Interaction in Micro- and Macrovascular Damage

Alberto Polo-Barranco, Carlos Rebolledo-Maldonado, Valeria Esquiaqui-Rangel, Andrea Nuñez-Mejia et autres

Diabetes mellitus (DM) is associated with a residual cardiovascular risk that persists even when lipid targets are achieved. Within this context, lipoprotein(a) [Lp(a)], an LDL-like particle of genetic origin with pro-atherogenic and antifibrinolytic properties, emerges as a key determinant in the progression …

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Hypercapnia as a Double-Edged Modulator of Innate Immunity and Alveolar Epithelial Repair: A PRISMA-ScR Scoping Review

Elber Osorio-Rodríguez, José Correa-Guerrero, Dairo Rodelo-Barrios, María Bonilla-Llanos et autres

Lung-protective ventilation and other experimental conditions raise arterial carbon dioxide tension (PaCO2) and alter pH. Short-term benefits are reported in non-infectious settings, whereas infection and/or prolonged exposure are typically harmful. This scoping review systematically maps immune-mediated effects of hypercapnia on innate immunity …

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Alcalosis metabólica en cuidados intensivos

Tomás Rodríguez Yánez, Jorge E. Rico-Fontalvo, Rodrigo Daza-Arnedo, Dairo Rodelo-Barrios et autres

Introduction: In the ICU, metabolic alkalosis is the most common acid-base disorder. A link has been observed between this disorder and an increased risk of death. However, this increased mortality is likely primarily due to the severity of the underlying disease rather …

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Characterization of Hypercapnia Effects in Experimental Models with or without Acute Lung Injury: A Scoping Review

Elber Osorio-Rodríguez, José Correa-Guerrero, Dairo Rodelo-Barrios, María Bonilla-Llanos et autres

Background: Ventilatory strategies in acute respiratory distress syndrome patients aim to mitigate the risk of acute lung injury (ALI). However, prolonged utilization of these strategies may precipitate alveolar carbon dioxide elevation and pH reduction. This scoping review endeavors to present extant knowledge …

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Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin America

Elber Osorio-Rodríguez, Dairo Rodelo-Barrios, Carlos Rebolledo-Maldonado, Alberto Polo-Barranco et autres

Leptospirosis is a re-emerging zoonotic disease that has had an unprecedented impact on most health systems in the world. The spectrum of symptoms is variable and usually ranges from asymptomatic cases to severe manifestations involving multiple organ dysfunction accompanied by jaundice, hemorrhage, …

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Sobreinfecciones intrahospitalarias y su relación con la mortalidad en pacientes obesos o diabéticos con COVID-19 críticamente enfermos

Elber Osorio-Rodríguez, Mauricio Aldana-Roa, Jhonny Patiño-Patiño, Rómulo Rodado-Villa et autres

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Actualización en el uso de terapias de reemplazo renal continuo (TRRC) en el paciente critico

Tomás Rodríguez Yánez, Rodrigo Daza-Arnedo, Dairo Rodelo-Barrios, Jhonny Jesús Patiño Patiño et autres

En los últimos años en pacientes críticos ha existido controversia con las técnicas de terapias de reemplazo renal existente asociado a la modalidad de elección, dosis y tiempo de inicio. Las terapias de reemplazo renal continua (TRRC) surgen como una estrategia sustituta …

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