Eric P. Anderson

Exposure–Response Relationships in Patients with Non‐Small‐Cell Lung Cancer and Other Solid Tumors Treated with Patritumab Deruxtecan (HER3‐DXd)

Li Li, Mark Andrew Lee, Rujuta H. Joshi, Yuan Xu et autres

Patritumab deruxtecan (HER3-DXd, also known as MK-1022), an antibody-drug conjugate consisting of a human epidermal growth factor receptor 3 (HER3) antibody attached to a topoisomerase I inhibitor payload (DXd), has demonstrated efficacy in patients with metastatic breast cancer and non-small cell lung …

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gPKPDviz : A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve

Tong Lu, Victor Poon, Logan Brooks, Erick F. Velasquez et autres

GPKPDviz is a Shiny application (app) dedicated to real-time simulation, visualization, and assessment of the pharmacokinetic/pharmacodynamic (PK/PD) models. Within the app, gPKPDviz is capable of generating virtual populations and complex dosing and sampling scenarios, which, together with the streamlined workflow, is designed …

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Population-Based Pharmacodynamic Modeling of Omalizumab in Pediatric Patients with Moderate to Severe Persistent Inadequately Controlled Allergic Asthma

Rui Zhu, Xiaoning Wang, Eric P. Anderson, Michelle Deng et autres

Omalizumab is the first approved anti-immunoglobulin E (IgE) agent for the treatment of moderate to severe persistent inadequately controlled allergic asthma in adults and adolescents (≥ 12 years old). In 2016, it was approved in pediatric patients (6-11 years old). The objective …

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Considerations in the Surgical Management of Unicuspid Aortic Stenosis

Andrew J. Gorton, Eric P. Anderson, Jonathan A. Reimer, Khaled Abdelhady et autres

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[Figure, Corneal foreign body. Image courtesy S Bhimji MD]

Anthony J. Camodeca, Eric P. Anderson

Malignant Solitary Fibrous Tumor of the Pleura

Amber Redmond, Eric P. Anderson, Christopher William Seder, Nicole M. Geissen

Malignant solitary fibrous tumors are rare growths of mesenchymal origin that can appear almost anywhere in the body; the most common location being the pleura. We present the case of a 61-year-old female with a left- sided pleural- based mass with apparent …

Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes

Yun Wang, Eric P. Anderson, Dimitris N. Tatakis

BACKGROUND: Smoking has significant negative impact on periodontal health and treatment outcomes. The molecular effects of smoking on oral immune homeostasis have not been fully elucidated. The present study aimed to provide a comprehensive assessment of smoking-associated gene expression changes in healthy …

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Serial Changes in Pulmonary Function Testing in A Patient with Tracheobronchial Amyloidosis: Relevance for Early Diagnosis

Cecilia L. Benz, Marcus Geffre, Eric P. Anderson, Kara J. Johnson et autres

Amyloidosis is a disease of abnormal extracellular deposition of proteins within tissues, commonly affecting solid organs such as the heart, liver, and kidneys. Less commonly, amyloidosis may affect the proximal tracheobronchial tree. Clinical symptoms are vague and may include shortness of breath, …

Corneal Foreign Body

Anthony J. Camodeca, Eric P. Anderson

Corneal foreign bodies account for the second most common form of ocular trauma, with corneal abrasions being number one. In general, major morbidity such as visual acuity loss is not common. Many corneal foreign bodies are superficial, and benign, albeit uncomfortable.

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Safety Performance of Flashing Yellow Arrow for Protected–Permissive Left-Turn Signal Control in Central Illinois

Kerrie L. Schattler, Eric P. Anderson, Trevor R. Hanson

In 2010, the Illinois Department of Transportation began implementing the flashing yellow arrow (FYA) at intersections operating with protected–permissive left-turn (PPLT) control. Research was conducted to evaluate the safety-effectiveness of FYAs at 86 intersections and 164 approaches in central Illinois. The effectiveness …

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Clostridium difficile infection in the pediatric surgery population

Kathryn T. Chen, Daniel J. Stephens, Eric P. Anderson, Robert D. Acton et autres

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Clostridium difficile Infection in a Pediatric Population

Kathryn T. Chen, Daniel J. Stephens, Eric P. Anderson, Robert D. Acton et autres