Brian Dizon

Long-term safety of canakinumab in patients with systemic juvenile idiopathic arthritis: 5-year results from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry

Alis Burciu, Amita Bansal, Anne Dennos, Deepak Narayanswamy et autres

BACKGROUND: Systemic juvenile idiopathic arthritis (SJIA) is a severe form of juvenile idiopathic arthritis characterized by fever, rash, chronic arthritis, and systemic inflammation. The introduction of biologics has improved the treatment options for SJIA. Canakinumab selectively inhibits interleukin-1β and is approved for …

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Efficient Tonsillar T Follicular Helper Cell Processing and Functional Analysis through High-dimensional Flow Cytometry

Qin Xu, Lihong Shi, Brian Dizon, Rylee J Beam et autres

T helper cells that aid in B cell isotype switching, germinal center (GC) formation, somatic hypermutation, and affinity maturation, thereby helping to orchestrate adaptive humoral immune responses in secondary lymphoid tissues during infection, autoimmunity, and vaccination. Understanding the development and function of …

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Human naïve B cells show evidence of anergy and clonal redemption following vaccination

Brian Dizon, Prasida Holla, Evan C. Mutic, Paul Schaughency et autres

Abstract In an era of predicted emerging pandemics, the production of effective vaccines may require an in-depth understanding of the biology of human naive B (B N ) cells. Here we provide evidence that the majority of B N cells expressed CD73, …

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In the activation of HPV-specific human B cells HPV-VLP vaccines mimic membrane-associated antigens

Charles Torgbor, Haewon Sohn, Brian Dizon, Evan C. Mutic et autres

B cell responses to membrane-presented antigens appear to be strongly favored over soluble antigens in vivo suggesting that vaccines that mimic membrane-presented antigens may be highly efficacious. We recently demonstrated that human B cell responses to membrane-associated but not to soluble antigens …

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Diagnosing a child presenting with symptoms suggesting Sjögren’s disease: a tool for clinical practice

Matthew L. Basiaga, Seunghee Cha, Akaluck Thatayatikom, Erin Treemarcki et autres

OBJECTIVE: Childhood SjD (cSjD) is a rare disease. There are no widely accepted diagnostic or classification criteria for cSjD. To fill this gap, members from the CARRA Sjögren Disease Workgroup and the International Childhood Sjögren Disease Workgroup created a clinical diagnostic algorithm. …

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Glycan-Reactive Innate-like B Cells and Developmental Checkpoints

James S. New, Brian Dizon, John F. Kearney, R. Glenn King

Using an Ig H chain conferring specificity for N-acetyl-d-glucosamine (GlcNAc), we developed transgenic (VHHGAC39 TG) mice to study the role of self-antigens in GlcNAc-reactive B-1 B cell development. In VHHGAC39 TG mice, GlcNAc-reactive B-1 B cell development during ontogeny and in adult …

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Complement receptor 1 is the human erythrocyte receptor for Plasmodium vivax erythrocyte binding protein

Seong‐Kyun Lee, Cécile Crosnier, Paola Carolina Valenzuela Leon, Brian Dizon et autres

The discovery that Africans were resistant to infection by Plasmodium vivax ( P. vivax ) led to the conclusion that P. vivax invasion relied on the P. vivax Duffy Binding Protein (PvDBP) interacting with the Duffy Antigen Receptor for Chemokines (DARC) expressed …

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B-1 B Cell–Derived Natural Antibodies against N-Acetyl- d -Glucosamine Suppress Autoimmune Diabetes Pathogenesis

James S. New, Brian Dizon, R. Glenn King, Neil S. Greenspan et autres

Environmental factors and host microbiota strongly influence type 1 diabetes (T1D) progression. We report that neonatal immunization with group A Streptococcus suppresses T1D development in NOD mice by promoting clonal expansion of N-acetyl-d-glucosamine (GlcNAc)-specific B-1 B cells that recognize pancreatic β cell-derived …

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Clinical outcomes and safety of anakinra in the treatment of multisystem inflammatory syndrome in children: a single center observational study

Brian Dizon, Christopher Redmond, Emily C. Gotschlich, Sangeeta Sule et autres

BACKGROUND AND OBJECTIVE: Evidence for the treatment of multisystem inflammatory syndrome in children (MIS-C) is lacking. Anakinra, which targets IL-1-mediated inflammation, is reserved for refractory cases of MIS-C; however, its use in the treatment of MIS-C is not clearly established. PATIENTS AND …

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The majority of circulating human B cells belong to a naïve anergic B cell subset distinguished by expression of CD73

Brian Dizon, Susan K. Pierce

Abstract In humans, it is estimated that ~40% of peripheral blood (PB) naïve (CD19+ CD27− CD45RBMEM− CD38−) B cells are in a state of anergy defined as IgD+ IgMlow. Presumably these anergic B cells express only weakly autoreactive B cell receptors (BCR) …

Clinical Outcomes and Safety of Anakinra in the Treatment of Multisystem Inflammatory Syndrome in Children: a Single Center Prospective Observational Study

Brian Dizon, Christopher Redmond, Emily C. Gotschlich, Sangeeta Sule et autres

Abstract Background and objective: Evidence for the treatment of multisystem inflammatory syndrome in children (MIS-C) is lacking. Anakinra, which targets IL-1-mediated inflammation, is reserved for refractory cases of MIS-C; however, its use in the treatment of MIS-C is not clearly established. Patients …

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Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces

Abhijit A. Ambegaonkar, Prasida Holla, Brian Dizon, Haewon Sohn et autres

The world's struggle to contain the SARS-CoV-2 epidemic, primarily through vaccination, has highlighted the importance of better understanding the biology of B cells that participate in defense against infectious diseases, both acute and chronic. Here, we focus on a population of human …

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