Antonia Martin-Martín

The polyamine inhibitor SAM486A increases the efficacy of adagrasib in non-small cell lung cancer cells harboring KRASG12C mutation

Antonia Martin-Martín, Carina Chipón, Constanza Guzman-Kunstmann, Sergio Guzmán-Kunstmann et autres

Abstract Background Non-small cell lung cancer (NSCLC) accounts for most lung cancer cases and poses major challenges due to late-stage diagnosis and limited options. A substantial subset of NSCLC harbors KRAS mutations, most commonly at codon 12. Although KRAS G12C inhibitors show …

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SAM486A-induced inhibition of AMD1: metabolic and epigenetic implications in non-small cell lung cancer cells

Matías Muñoz-Uribe, Antonia Martin-Martín, Rafael Agustin Burgos, Pablo Alarcón et autres

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Dual-Action Gemcitabine Delivery: Chitosan–Magnetite–Zeolite Capsules for Targeted Cancer Therapy and Antibacterial Defense

Yuly Andrea Guarín-González, G. Cabello, José Reyes‐Gasga, Yanko Moreno-Navarro et autres

Cancer and infectious diseases are two of the world’s major public health problems. Gemcitabine (GEM) is an effective chemotherapeutic agent against several types of cancer. In this study, we developed macrocapsules incorporating GEM into a chitosan matrix blended with magnetite and zeolite …

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Gemcitabine Delivery System Based on Chitosan Capsules with Magnetite and Natural Zeolite (Clinoptilolite). Synthesis, Characterization and Evaluation of Its Anticancer and Bactericidal Properties

Yuly Andrea Guarín-González, G. Cabello, José Reyes‐Gasga, Yanko Moreno-Navarro et autres

Cancer and infectious diseases are two of the world's major public health problems. Gemcitabine (GEM) is an effective chemotherapeutic agent against several types of cancer. In this study, we developed macrocapsules by incorporating GEM into a chitosan matrix blended with magnetite and …

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Multifunctional nano-in-microparticles for targeted lung cancer cells: Synthesis, characterization and efficacy assessment

Yuly Andrea Guarín-González, G. Cabello, Carlos von Plessing, Rodrigo Segura et autres

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Synthesis of Nano-in-Microcapsule Delivery Systems of Nanomagnetite, Microzeolite and Gemcitabine in a Chitosan Matrix, with Activity Against Lung Cancer Cells

Yuly Andrea Guarín-González, G. Cabello, Carlos Von-Plessing, Rodrigo Segura et autres

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Abstract C143: Unveiling synergistic interplay between KRASG12C inhibitors and the polyamine synthesis inhibitor SAM486 against lung cancer cells: An in vitro study

Rodrigo López‐Muñoz, Antonia Martin-Martín, Carina Chipón, Neudo Buelvas et autres

Abstract Introduction: Non-small cell lung cancer (NSCLC) represents the most lethal variant of lung cancer. The G12C mutation in the KRAS protein occurs in 20-30% of NSCLC patients and is correlated with an unfavorable prognosis. Adagrasib and sotorasib are emerging compounds that …

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Indomethacin Induces Spermidine/Spermine-N1-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells

Neudo Buelvas, Isidora Ugarte-Vio, Laura Asencio-Leal, Matías Muñoz-Uribe et autres

Indomethacin is a non-selective NSAID used against pain and inflammation. Although cyclooxygenase (COX) inhibition is considered indomethacin’s primary action mechanism, COX-independent ways are associated with beneficial effects in cancer. In colon cancer cells, the activation of the peroxisome proliferator-activated receptor-γ (PPAR-γ) is …

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Ambient Particulate Matter in Valdivia, Chile: Temporal Analysis and Compared Cytotoxicity in Lung Epithelial Cells

Andres R. Henriquez, Felipe Reyes, Neudo Buelvas, Antonia Martin-Martín et autres

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Mind the Curve: Dose–Response Fitting Biases the Synergy Scores across Software Used for Chemotherapy Combination Studies

Olga Fuentealba-Manosalva, Matías Mansilla, Neudo Buelvas, Antonia Martin-Martín et autres

Drug combinations are increasingly studied in the field of anticancer agents. Mathematical models, such as Loewe, Bliss, and HSA, are used to interpret drug combinations, while informatics tools help cancer researchers identify the most effective combinations. However, the different algorithms each software …

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Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

Freddy López-Contreras, Matías Muñoz-Uribe, Jorge Pérez-Laines, Laura Ascencio-Leal et autres

Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory …

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Reconsidering the Role of Cyclooxygenase Inhibition in the Chemotherapeutic Value of NO-Releasing Aspirins for Lung Cancer

Antonia Martin-Martín, Andrés Rivera-Dictter, Matías Muñoz-Uribe, Freddy López-Contreras et autres

Nitric oxide-releasing aspirins (NO-aspirins) are aspirin derivatives that are safer than the parent drug in the gastrointestinal context and have shown superior cytotoxic effects in several cancer models. Despite the rationale for their design, the influence of nitric oxide (NO•) on the …

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