Accès ouvert
2026
preprint
OpenAlex
Piotr Włodzimierz, Estela Pérez-Román, Jacob Gonzalez Isa, Michael Hong et autres
Centromeres evolved at the root of eukaryotes to segregate chromosomes during cell division. Despite their ancient origin, centromeric DNA sequences evolve rapidly and adopt diverse architectures, including point centromeres, satellite arrays, transposon clusters, and holocentrics. To analyse centromere evolution at a broad …
pl, gb, us, cz, de, fr
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Accès ouvert
2026
preprint
OpenAlex
Anna Glushkevich, Robin Burns, Maria Vasilarou, Estela Pérez-Román et autres
Centromeres are critical for accurate segregation of chromosomes and are often composed of megabases of tandemly arranged satellite repeats. Yet, despite their conserved function, the DNA sequence of centromeres is, paradoxically, rapidly evolving. To understand the nature of centromeric sequence turnover, we …
de, gb, se, jp, fi
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Accès ouvert
2026
preprint
OpenAlex
Robin Burns, Terezie M. Mandáková, Chris Morgan, Stephanie D. Topp et autres
Abstract Centromeres are essential for chromosome segregation and are epigenetically defined by CENH3/CENP-A nucleosomes. Centromere position along chromosomes varies within and between species, ranging from telocentric to metacentric architectures. Yet, how centromere position influences chromosome inheritance and karyotype evolution remains poorly understood. …
gb, cz
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Accès ouvert
2026
preprint
OpenAlex
Ivona Biocanin, Alejandro Edera, Clotilde Garrido, Adrien Vidal et autres
The mechanisms underlying the emergence of new DNA repeat classes remain poorly understood. One such example is the formation of interstitial telomeric repeat (ITR) domains commonly viewed as telomere-fossil byproducts of chromosome rearrangements. Here, we report that in Arabidopsis thaliana , ITRs …
fr, gb, de, cz
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Accès ouvert
2026
preprint
OpenAlex
Ivona Biocanin, Alejandro Edera, Clotilde Garrido, Adrien Vidal et autres
This preprint is also available on bioRXiv: doi: https://doi.org/10.64898/2026.05.10.723265
fr, gb, de, cz
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Accès ouvert
2026
preprint
OpenAlex
Ivona Biocanin, Alejandro Edera, Clotilde Garrido, Adrien Vidal et autres
This preprint is also available on bioRXiv: doi: https://doi.org/10.64898/2026.05.10.723265
fr, gb, de, cz
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Ivona Biocanin, Alejandro Edera, Clotilde Garrido, Adrien Vidal et autres
This preprint is also available on bioRXiv: doi: https://doi.org/10.64898/2026.05.10.723265
fr, gb, de, cz
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Robin Burns, Alison Dawn Scott, Polina Yu. Novikova
The origin of a polyploid can hinge on a single errant cell division, a mistake in the cell cycle that leads to genome-doubling and re-writes the rules of chromosome pairing and segregation. In plants, the evolutionary significance of these errors is magnified …
gb, de, be
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Accès ouvert
2025
article
OpenAlex
Nicola Gorringe, Stephanie D. Topp, Robin Burns, Fernando A. Rabanal et autres
Eukaryotic centromeres mediate chromosome segregation during cell division. Plant centromeres are loaded with CENH3-variant nucleosomes, which direct kinetochore formation and spindle-microtubule interaction. Centromeres are frequently composed of megabase-scale satellite repeat arrays, or retrotransposon nests. In monocentric genomes, such as the model plant …
gb, pt, jp, de
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Accès ouvert
2025
article
OpenAlex
Robin Burns, Anna Glushkevich, Aboli Kulkarni, Uliana K. Kolesnikova et autres
Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long-term stabilization involves rediploidization, returning the genome to a diploid-like state. …
gb, de, cz, be
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Accès ouvert
2025
article
OpenAlex
Jenia Binenbaum, Vanda Gabriela Adamkova, Hugh J.L. Fryer, Linhao Xu et autres
H3K4me3 is a fundamental and highly conserved chromatin mark across eukaryotes, playing a central role in many genome-related processes, including transcription, maintenance of cell identity, DNA damage repair, and meiotic recombination. However, identifying the causal function of H3K4me3 in these diverse pathways …
gb, pl, us
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Accès ouvert
2025
article
OpenAlex
Alison Dawn Scott, Uliana K. Kolesnikova, Anna Glushkevich, Laura Steinmann et autres
Abundance of established polyploid lineages varies across lineages, evolutionary time, and geography, suggesting both genetics and environment play a role in polyploid persistence. We show Arabidopsis lyrata is the most polyploid-rich species complex in the Arabidopsis genus, with multiple origins of autotetraploidy. …
de, cz, gb, ru
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