Jeswin Joseph

Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody Responses

Kizzmekia S. Corbett, Christian K. O. Dzuvor, Sydney P. Moak, Lindsay R. McManus et autres

us, fr (code pays fourni par la source)

Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context–Dependent Neutralization

Jeswin Joseph, Lingshu Wang, Sheena Vasquez, Chia-Ming Su et autres

Abstract Endemic human coronaviruses (HCoVs), such as HCoV-HKU1, account for ∼30% of common colds each year and can cause serious upper and lower respiratory infections, yet no licensed vaccines or therapeutic antibodies target HCoVs. Despite being endemic to the human population, little …

us, il, qa (code pays fourni par la source)

Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody Responses

Christian K. O. Dzuvor, Sydney P. Moak, Lindsay R. McManus, Abigail Thomas et autres

Abstract Four seasonal endemic human coronaviruses (EhCoVs), HKU1-CoV, OC43-CoV, 229E-CoV, and NL63-CoV, are culprits of mild upper respiratory and periodic severe diseases in vulnerable populations. Despite their prevalence, understanding EhCoVs’ antigenic and immune signatures remains elusive. SARS-CoV-2 has evolved as the fifth …

us, fr (code pays fourni par la source)

Lumazine Synthase Nanoparticles as a Versatile Platform for Multivalent Antigen Presentation and Cross-Protective Coronavirus Vaccines

Jeswin Joseph, Priyanca Ahlawat, Malavika Prakash, Gayatri Kandpal et autres

Lumazine synthase (LS), a bacterial protein that self-assembles into 60-mer icosahedral virus-like nanoparticles, has emerged as a promising platform for nanoparticle-based drug delivery and vaccine design. However, detailed biophysical characterization of the LS nanoparticle vaccine has not been well-studied. In this study, …

fr, sk, in, gb, ca (code pays fourni par la source)

SARS‐CoV ‐2 neutralizing antibody epitopes are overlapping and highly mutated which raises the chances of escape variants and requires development of broadly reactive vaccines

Jeswin Joseph, Sukhada Darpe, Grishma Kulkarni, Victor Stalin Raj

The rapid adaptation of SARS-CoV-2 within the host species and the increased viral transmission triggered the evolution of different SARS-CoV-2 variants. Though numerous monoclonal antibodies (mAbs) have been identified as prophylactic therapy for SARS-CoV-2, the ongoing surge in the number of SARS-CoV-2 …

in (code pays fourni par la source)

SARS-CoV-2 neutralizing antibody epitopes are overlapping and highly mutated which raises the chances of escape variants and requires development of broadly reactive vaccines

Victor Stalin Raj, Jeswin Joseph, Sukhada Darpe, Grishma Kulkarni

The rapid adaptation of SARS-CoV-2 within the host species and the increased viral transmission triggered the evolution of different SARS-CoV-2 variants. Though numerous monoclonal antibodies (mAbs) have been identified as prophylactic therapy for SARS-CoV-2, the ongoing surge in the number of SARS-CoV-2 …

in (code pays fourni par la source)

The use of Pseudotyped Coronaviruses for the Screening of Entry Inhibitors: Green Tea Extract Inhibits the Entry of SARS-CoV-1, MERSCoV, and SARS-CoV-2 by Blocking Receptor-spike Interaction

Jeswin Joseph, Karthika Thankamani, Victor Stalin Raj

BACKGROUND: Coronaviruses (CoVs) infect a wide range of animals and birds. Their tropism is primarily determined by the ability of the spike protein to bind to a host cell surface receptor. The ongoing outbreak of SARS-CoV-2 inculcates the need for the development …

in (code pays fourni par la source)

SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain Signaling

Karthika Thankamani, Jeswin Joseph, V.R. Akshay Das, Niranjana Nair et autres

Recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and -2 initiate virus infection by binding of their spike glycoprotein with the cell-surface receptor angiotensin-converting enzyme 2 (ACE2) and enter into the host cells mainly via the clathrin-mediated endocytosis pathway. However, the internalization …

in (code pays fourni par la source)

Epigallocatechin-3-gallate (EGCG): a potential molecule for the development of therapeutics against emerging SARS-CoV-1, MERS-CoV and SARS-CoV-2 coronaviruses

Jeswin Joseph, V.R. Akshay Das, Victor Stalin Raj

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a contagious coronavirus following the two major outbreaks of SARS-CoV-1 in 2003 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 [1] .To date, approximately 147 million laboratory-confirmed cases of SARS-CoV-2 infection …

in (code pays fourni par la source)

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

Sameer Kumar Malladi, Randhir Singh, S. K. Singh Pandey, Savitha Gayathri et autres

Virtually all SARS-CoV-2 vaccines currently in clinical testing are stored in a refrigerated or frozen state prior to use. This is a major impediment to deployment in resource-poor settings. Furthermore, several of them use viral vectors or mRNA. In contrast to protein …

in (code pays fourni par la source)

Green tea and Spirulina extracts inhibit SARS, MERS, and SARS-2 spike pseudotyped virus entry in vitro

Jeswin Joseph, Karthika Thankamani, Ariya Ajay, Vimal Das et autres

Abstract Coronaviruses (CoVs) infect a wide range of animals and birds. Their tropism is primarily determined by the ability of the spike (S) protein to bind to a host cell surface receptor. The rapid outbreak of emerging novel coronavirus, SARS-CoV 2 in …

in (code pays fourni par la source)

Rewiring of one carbon metabolism in Salmonella serves as an excellent live vaccine against systemic salmonellosis

Akshay Datey, Meghanashree M. Shreenivas, Giridhar Chandrasekharan, Jeswin Joseph et autres

in (code pays fourni par la source)