Matthew Georgenson Drake

Muc5ac mediates anti-viral immunity and virus-induced parasympathetic nerve dysfunction

James M. Kornfield, Shelby T Hoffmeister, Ubaldo De La Torre, Chadwick Smith et autres

Abstract Respiratory viruses can induce excessive bronchoconstriction in both asthmatic and healthy airways. Airway mucins such as Muc5ac form the first line of defense against inhaled pathogens. However, when produced in excess, they can also contribute to airway narrowing and mucus plug …

us (code pays fourni par la source)

Response

H. E. Freeman, Kelly C. Vranas, Sarah Tuthill, Matthew Georgenson Drake

us (code pays fourni par la source)

Optogenetic vagotomy inhibits reflex bronchoconstriction and cardiac chronotropy

Aubrey B. Pierce, Alexandra B. Pincus, James M. Kornfield, Becky J. Proskocil et autres

Optogenetics involves genetic insertion of light-sensitive ion channels into nerves, such as with cre-based recombination. The recent increase in cre-based mouse lines has expanded our ability to test the roles of peripheral nerves in homeostasis and in disease models. Here, we generated …

us (code pays fourni par la source)

Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve Depletion

Barnaby Hirons, Katherine L. Rhatigan, William H. McNulty, Richard Douglas Turner et autres

Abstract Introduction Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a genetic neurodegenerative condition associated with chronic cough and cough hypersensitivity. The neuropathic mechanisms underlying cough in CANVAS are unknown. In a father and son with CANVAS-associated cough, we investigated …

gb, ru, au, it, us (code pays fourni par la source)

Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach

Britt Erika Hanson, Nenad Svrzikapa, Ning Bo Feng, Hans J. Friedrichsen et autres

Abstract Upstream open reading frames (uORFs) are short translated regions that occur in the 5□ untranslated regions (5□ UTRs) of mRNA transcripts where they primarily serve to repress expression translation of the downstream primary open reading frame (pORF). Their widespread presence across …

gb, mk, de, se (code pays fourni par la source)

Airway Mucin Muc5b is Required for Parainfluenza Virus-induced Airway Hyperresponsiveness

James M. Kornfield, Chadwick P. Smith, Christopher M. Evans, B.J. Proskocil-Chen et autres

Abstract Rationale: Airway mucus forms a physical barrier that serves as the first line of defense against respiratory viruses. The airway mucin Muc5b is a principal component of airway mucus in healthy lungs. Whether Muc5b is specifically involved in preventing viral entry …

us (code pays fourni par la source)

Touching a Nerve: Neuroimmune Interactions in Asthma

James M. Kornfield, Hoyt A.T.K. Bright, Matthew Georgenson Drake

Asthma is an inflammatory airway disease characterized by excessive bronchoconstriction and airway hyperresponsiveness. Airway nerves play a crucial role in regulating these processes. In asthma, interactions between inflammatory cells and nerves result in nerve dysfunction, which worsens airway function. This review discusses …

us (code pays fourni par la source)

High-Flow Nasal Cannula Liberation

Howard E. Freeman, Kelly C. Vranas, Sarah Tuthill, Matthew Georgenson Drake

us (code pays fourni par la source)

Effects of maternal edible THC consumption on offspring lung growth and function in a rhesus macaque model

Lyndsey E. Shorey‐Kendrick, Adam Crosland, Matthias C. Schabel, Ilhem Messaoudi et autres

In a translational rhesus macaque model, chronic prenatal delta-9-tetrahydrocannabinol exposure resulted in decreased lung volumes in offspring measured at 6 mo of age. These decreases correlated with altered DNA methylation in the lung, including at genes involved in extracellular matrix organization, lung …

us (code pays fourni par la source)

Therapeutic and mechanistic advances in chronic cough

Anju Tripathi Peters, Kenneth W. Altman, Peter V. Dicpinigaitis, Matthew Georgenson Drake et autres

us, ca (code pays fourni par la source)

Parasympathetic Airway Hyperreactivity Is Enhanced in Acute but Not Chronic Eosinophilic Asthma Mouse Models

Alexandra B. Pincus, Aubrey B. Pierce, Nicole Kappel, Katie M. Lebold et autres

Abstract Airway hyperreactivity in asthma is mediated by airway nerves, including sensory nerves in airway epithelium and parasympathetic nerves innervating airway smooth muscle. Isolating the function of these two nerve populations in vivo, to distinguish how each is affected by inflammatory processes …

us (code pays fourni par la source)

No Pain, No Gain (and No Cough)? Discrete Brainstem Nuclei Coordinate Reflexive Cough and Pain Responses

Ubaldo De La Torre, Matthew Georgenson Drake

us (code pays fourni par la source)