Valentina Allegro

Amyloidosis

Valentina Allegro, Carla Indennidate, Andrea Lalario, Aldostefano Porcari et autres

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Serum transthyretin as a staging biomarker in ATTR cardiomyopathy: promise, limitations, and the path forward

Valentina Allegro, Gianfranco Sinagra, Marco Merlo

Amyloidosis

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Classification of cardiomyopathies: bringing order to complexity

Maria Perotto, Carola Pio Loco Detto Gava, Federico Garoia, Alessandro Folgheraiter et autres

Cardiomyopathy classification remains challenging due to their extraordinary clinical, morphological, and genetic heterogeneity. As diagnostic technologies evolve, so too must the frameworks by which we conceptualize and communicate these diseases. Since the 2008 ESC morphofunctional classification and the genotype-phenotype integrated MOGE(S) system …

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SIMPLE AND SPECIFIC PREDICTION OF THE FINAL DIAGNOSIS IN PATIENTS WITH SUSPECTED AMYLOID CARDIOMYOPATHY AND INDICATION TO TISSUE BIOPSY

Alberto Aimo, G Vergaro, Vincenzo Castiglione, Matteo Serenelli et autres

Abstract Background Amyloid cardiomyopathy (CM) is increasingly recognized as an important cause of heart failure. In patients with suspected amyloid CM, the presence of a monoclonal protein may indicate light–chain (AL) amyloidosis or may be an incidental finding in those with transthyretin …

Clinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration

Aldostefano Porcari, Yousuf Razvi, Francesco Cappelli, Christian Nitsche et autres

Importance: Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages with no heart failure (HF) symptoms and a wide range of cardiac amyloid infiltration. Objective: To characterize the clinical phenotype and natural history of asymptomatic patients with …

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Abstract 4144740: Characteristics and Natural History of Early ATTR Cardiac Amyloid Infiltration

Aldostefano Porcari, Yousuf Razvi, Francesco Cappelli, Christian Nitsche et autres

Background: Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages with no heart failure (HF) symptoms and a wide range of cardiac amyloid infiltration. Aim: The aim of the study was to characterize the natural history and …

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SGLT2 Inhibitor Therapy in Patients With Transthyretin Amyloid Cardiomyopathy

Aldostefano Porcari, Francesco Cappelli, Christian Nitsche, Daniela Tomasoni et autres

BACKGROUND: Transthyretin cardiomyopathy (ATTR-CM) was an exclusion criterion in randomized clinical trials of sodium-glucose cotransporter 2 inhibitors (SGLT2i). OBJECTIVES: This study sought to assess the effectiveness and tolerability of SGLT2i in patients with ATTR-CM. METHODS: Data of 2,356 consecutive ATTR-CM patients (2014-2022) …

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Specific Therapy in Transthyretin Amyloid Cardiomyopathy

Riccardo Saro, Valentina Allegro, Marco Merlo, Franca Dore et autres

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Abnormal conduction-induced cardiomyopathy: a poorly explored entity

Andrea Lalario, Maddalena Rossi, Valentina Allegro, Giulia Gagno et autres

A dyssynchronous biventricular activation, which can be determined by left bundle branch block, chronic right ventricular pacing, frequent premature ventricular complexes, or pre-excitation, can cause a global abnormal contractility, thus leading to systolic dysfunction and left ventricular remodelling in a unique nosological …

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Differential Diagnoses in Clinical Mimics

Annamaria Del Franco, Marco Merlo, Giulia Biagioni, Carlotta Mazzoni et autres

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Left Ventricular Wall Thickness and Severity of Cardiac Disease in Women and Men with Transthyretin Amyloidosis

Alberto Aimo, Daniela Tomasoni, Aldostefano Porcari, Giuseppe Vergaro et autres

Abstract Aims Cardiac amyloidosis (CA) is due to a deposition of amyloid fibrils in the heart causing an increase in wall thickness. A left ventricular (LV) wall thickness ≥12 mm plus at least one red flag should raise the suspicion of CA. …

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Evolving trends in epidemiology and natural history of cardiac amyloidosis: 30-year experience from a tertiary referral center for cardiomyopathies

Aldostefano Porcari, Valentina Allegro, Riccardo Saro, Guerino Giuseppe Varrà et autres

Objective Natural history of cardiac amyloidosis (CA) is poorly understood. We aimed to examine the changing mortality of different types of CA over a 30-year period. Patients and methods Consecutive patients included in the “Trieste CA Registry” from January 1, 1990 through …

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