Samantha J. Brace-McDonnell

Recruiting women with ductal carcinoma in situ to a randomised controlled trial: lessons from the LORIS study

Sally J Wheelwright, Lucy Matthews, Valerie A. Jenkins, Shirley F. May et autres

BACKGROUND: The LOw RISk DCIS (LORIS) study was set up to compare conventional surgical treatment with active monitoring in women with ductal carcinoma in situ (DCIS). Recruitment to trials with a surveillance arm is known to be challenging, so strategies to maximise …

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The presentation, management and outcome of patients with ductal carcinoma in situ (DCIS) with microinvasion (invasion ≤1 mm in size)—results from the UK Sloane Project

Abeer M. Shaaban, Bridget Hilton, Karen Clements, David John Dodwell et autres

BACKGROUND: The diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial. METHODS: We analysed the outcomes of patients with DCIS with and without microinvasion diagnosed between 2003 and 2012 within the Sloane project. RESULTS: Microinvasion was recorded in 521 of 11,285 …

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Abstract P1-22-06: A longitudinal cohort study of outcomes in 311 women with unresected ductal carcinoma in situ detected through the English breast screening programme

Karen Clements, Anthony Maxwell, Bridget Hilton, Matthew Wallis et autres

Abstract Background The variable natural history of ductal carcinoma in situ (DCIS) is poorly understood. The aim of this retrospective cohort study was to determine the outcomes of women who were diagnosed through the English National Health Service Breast Screening Programme (NHS …

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Abstract P1-22-01: Predictors of inaccurate pre-operative size assessment of screen detected DCIS and impact on recurrence rates

Cliona Kirwan, Bridget Hilton, Karen Clements, Hilary Stobart et autres

Abstract Background: Disparity between mammographic and pathological sizing of DCIS can lead to surgical overtreatment, with poor cosmetic outcomes of breast conservation surgery (BCS) or inappropriate mastectomy versus undertreatment, with subsequent need for re-excision. In addition, where mammographic size is smaller than …

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Abstract P3-12-36: The diagnosis and prognosis of ductal carcinoma in situ (DCIS) with microinvasion - Results from the United Kingdom Sloane project

Abeer M. Shaaban, Bridget Hilton, Karen Clements, David John Dodwell et autres

Abstract Background/objectives The natural history of microinvasive carcinoma of the breast (one or more foci of invasion of 1mm or less) and its optimal management remain controversial. We analysed the frequency and outcome of patients with DCIS plus microinvasion within a large …

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Patient-centred outcomes for prehospital trauma trials: A systematic review and patient involvement exercise

James M Hancox, Emma Toman, Samantha J. Brace-McDonnell

Introduction Outcome measures are used in clinical trials to determine efficacy of interventions. We aimed to determine which outcome measures in prehospital major trauma trials have been reported in the literature, and which of these are most patient-centred. Methods A systematic review …

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Feasibility of data linkage in the PARAMEDIC trial: a cluster randomised trial of mechanical chest compression in out-of-hospital cardiac arrest

Chen Ji, Tom Quinn, Lucia Gavalova, Ranjit Lall et autres

OBJECTIVES: There is considerable interest in reducing the cost of clinical trials. Linkage of trial data to administrative datasets and disease-specific registries may improve trial efficiency, but it has not been reported in resuscitation trials conducted in the UK. To assess the …

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Data quality and 30-day survival for out-of-hospital cardiac arrest in the UK out-of-hospital cardiac arrest registry: a data linkage study

Sangeerthana Rajagopal, Scott J Booth, Terry P. Brown, Chen Ji et autres

OBJECTIVES: The Out-of-Hospital Cardiac Arrest Outcomes (OHCAO) project aims to understand the epidemiology and outcomes of out-of-hospital cardiac arrest (OHCA) across the UK. This data linkage study is a subproject of OHCAO. The aim was to establish the feasibility of linking OHCAO …

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Improving data quality in a UK out-of-hospital cardiac arrest registry through data linkage between the Out-of-Hospital Cardiac Arrest Outcomes (OHCAO) project and NHS Digital

Sangeerthana Rajagopal, Scott J Booth, Terry P. Brown, Chen Ji et autres

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Post-admission outcomes of participants in the PARAMEDIC trial: A cluster randomised trial of mechanical or manual chest compressions

Chen Ji, Ranjit Lall, Tom Quinn, Charlotte Kaye et autres

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Establishing the values for patient engagement (PE) in health-related quality of life (HRQoL) research: an international, multiple-stakeholder perspective

Kirstie L. Haywood, Anne Lyddiatt, Samantha J. Brace-McDonnell, Sophie H. Staniszewska et autres

PURPOSE: Active patient engagement is increasingly viewed as essential to ensuring that patient-driven perspectives are considered throughout the research process. However, guidance for patient engagement (PE) in HRQoL research does not exist, the evidence-base for practice is limited, and we know relatively …

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Emerging Guidelines for Patient Engagement in Research

John Kirwan, Maarten de Wit, Lori B. Frank, Kirstie L. Haywood et autres

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