Mark Clayer

The Modified Posterior Approach to the Femur and Thigh: A Quadriceps Sparing Technique

Luke J. Johnson, Jakub Jagiello, Mark Clayer

There are 5 main surgical approaches to the femur: lateral, anterolateral, anteromedial, posterolateral, and posterior. The lateral approach is extensile but is a direct muscle-cutting approach through the vastus lateralis that causes effective muscle loss through denervation and transection. The anterolateral approach …

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Data from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

Abstract Nutlin-3a is a small-molecule antagonist of p53/MDM2 that is being explored as a treatment for sarcoma. In this study, we examined the molecular mechanisms underlying the sensitivity of sarcomas to Nutlin-3a. In an ex vivo tissue explant system, we found that …

Supplementary Figure 6 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 34K, GADD45A is hypermethylated in Ewing sarcoma cell lines.

Supplementary Figure 4 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 43K, Induction of GADD45A and BBC3 is associated with Nutlin-3a induced apoptosis.

Supplementary Table 1 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 72K, Primers utilised in this study.

Supplementary Figure 5 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 58K, GADD45A and sarcoma pathology.

Supplementary Figure 1 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 44K, Comparison of sequencing facilities.

Supplementary Figure 3 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 67K, TP53 pathway alterations do not mediate sarcoma cytostatic response to Nutlin-3a.

Supplementary Figure 2 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 178K, Nutlin-3a induces cytostatic responses in sarcoma patient material.

Supplementary Figure 5 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 58K, GADD45A and sarcoma pathology.

Supplementary Figure 2 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 178K, Nutlin-3a induces cytostatic responses in sarcoma patient material.

Supplementary Figure 4 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I. Pishas, Susan J. Neuhaus, Mark Clayer, Andreas Schreiber et autres

PDF file - 43K, Induction of GADD45A and BBC3 is associated with Nutlin-3a induced apoptosis.