D.E. Ferguson

Abstract 5745: Discovery of AZD4956, a potent and selective inhibitor of DNA polymerase theta, a clinical candidate for treatment of HRR-deficient tumors in combination with saruparib

Bernard C. Barlaam, Josep V. Forment, Lee Mulderrig, de Renty Christelle et autres

Abstract Deficiency in the homologous recombination repair (HRR) pathway, which is key for high-fidelity DNA double-strand break (DSB) repair, is prevalent across various cancers (including ovarian, breast, pancreatic, and prostate). It frequently arises from loss-of-function mutations in BRCA1, BRCA2, or other HRR-associated …

gb, sg, nl, kr, us, pl (code pays fourni par la source)

Impact of the physical-chemical properties of poly(lactic acid)–poly(ethylene glycol) polymeric nanoparticles on biodistribution

Mark J. Jackman, Weimin Li, Aaron Smith, David A. Workman et autres

gb, sg, us (code pays fourni par la source)

How a proposed law could cut off legal aid for low-income people

D.E. Ferguson

ca (code pays fourni par la source)

CANADIAN BAR REVIEW EDITION ON LEGAL EDUCATION: INTRODUCTION FROM THE CBA LEGAL FUTURES INITIATIVE AND THE CBA EQUAL JUSTICE INITIATIVE

Allan Fineblit, Karen Van Dyck, Michele Leering, D.E. Ferguson

NUMÉRO DE LA REVUE DU BARREAU CANADIEN SUR LA FORMATION JURIDIQUE: PRÉFACE DU PROJET AVENIRS EN DROIT ET DE L’INITIATIVE JUSTICE POUR TOUS DE L’ABC

Allan Fineblit, Karen Van Dyck, Michele Leering, D.E. Ferguson

Abstract 311: Development of AZD2811, an aurora kinase B inhibitor, incorporated into an AccurinTM nanoparticle for use in haematological and solid cancers

Susan E. Ashton, Nicholas Floch, Paula Taylor, Colin Howes et autres

Abstract A nanoparticle formulation of AZD2811, a selective aurora kinase B inhibitor, is currently under clinical development for the treatment of both haematological and solid tumour disease. AZD2811 is the active derivative of the prodrug Barasertib (AZD1152) which gave promising clinical activity …

gb, us (code pays fourni par la source)

Scientific Ballooning Technologies Workshop STO-2 Thermal Design and Analysis

D.E. Ferguson

The heritage thermal model for the full STO-2 (Stratospheric Terahertz Observatory II), vehicle has been updated to model the CSBF (Columbia Scientific Balloon Facility) SIP-14 (Scientific Instrument Package) in detail. Analysis of this model has been performed for the Antarctica FY2017 launch …

us (code pays fourni par la source)

Automated production and quality testing of [18F]labeled radiotracers using the BG75 system

Atilio I. Anzellotti, J. E. Bailey, D.E. Ferguson, Aaron R. McFarland et autres

us, bg (code pays fourni par la source)

Towards the Full Automation of QC Release Tests for [18F]fluoride-labeled Radiotracers

Atilio I. Anzellotti, Aaron R. McFarland, D.E. Ferguson, Ken F. Olson

The automation of quality control methods used for release of [18F]fluoride-labeled radiotracers is a logical next step for increasing reliability and decreasing exposure in day-to-day clinical manufacture. In this work we evaluate the suitability for automation in six key release tests: Radiochemical …

Measurement of long lived radioactive impurities retained in the disposable cassettes on the Tracerlab MX system during the production of [18F]FDG

D.E. Ferguson, Phil Orr, J. Gillanders, George Corrigan et autres

gb (code pays fourni par la source)

Welding Technology. Program CIP: 48.0508 - WELDING.

D.E. Ferguson

Industrial Maintenance

D.E. Ferguson