Accès ouvert
2024
article
OpenAlex
Letao Yang, Christopher Rathnam, Yannan Hou, Misaal Patel et autres
The ability to precisely arrange and control the assembly of diverse cell types into intricate three-dimensional (3D) structures remains a critical challenge in tissue engineering. Herein, we describe a versatile and programmable 3D cell sheet assembly technology by developing biodegradable nanochannel (BNC) …
us, cn
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Letao Yang, Christopher Rathnam, T. Hidaka, Yannan Hou et autres
The growing knowledge of the links between aberrant mitochondrial gene transcription and human diseases necessitates both an effective and dynamic approach to control mitochondrial DNA (mtDNA) transcription. To address this challenge, we developed a nanoparticle-based synthetic mitochondrial transcription regulator ( MitoScript ). …
us, jp
(code pays fourni par la source)
Accès ouvert
2023
paratext
OpenAlex
Yanbang Li, Rohin Biswas, William P. Kopcha, Thierry Dubroca et autres
Fullerenes. In their Research Article (e202211704), Jianyuan Zhang et al. report the synthesis of metallobuckytrio (MBT), a three-buckyball system, as a modular platform for a family of structurally defined metallofullerene derivatives that can safely carry rare-earth elements.
us, es
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Yanbang Li, Rohin Biswas, William P. Kopcha, Thierry Dubroca et autres
Fullerenes. In their Research Article (e202211704), Jianyuan Zhang et al. report the synthesis of metallobuckytrio (MBT), a three-buckyball system, as a modular platform for a family of structurally defined metallofullerene derivatives that can safely carry rare-earth elements.
us, es
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Yanbang Li, Rohin Biswas, William P. Kopcha, Thierry Dubroca et autres
Abstract Endohedral metallofullerenes (EMFs) are excellent carriers of rare‐earth element (REE) ions in biomedical applications because they preclude the release of toxic metal ions. However, existing approaches to synthesize water‐soluble EMF derivatives yield mixtures that inhibit precise drug design. Here we report …
us, es
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Yanbang Li, Rohin Biswas, William P. Kopcha, Thierry Dubroca et autres
Abstract Endohedral metallofullerenes (EMFs) are excellent carriers of rare‐earth element (REE) ions in biomedical applications because they preclude the release of toxic metal ions. However, existing approaches to synthesize water‐soluble EMF derivatives yield mixtures that inhibit precise drug design. Here we report …
us, es
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Jeffrey Luo, Letao Yang, Sy‐Tsong Dean Chueng, Brian Conley et autres
Seamlessly integrating soluble factors onto biomedical scaffolds with a precisely manufactured topography for efficient cell control remains elusive since many scaffold fabrication techniques degrade payloads. Surface adsorption of payloads onto synthesized nanoscaffolds retains bioactivity by removing exposure to harsh processing conditions at …
us
(code pays fourni par la source)
2022
article
OpenAlex
Letao Yang, Kapil D. Patel, Christopher Rathnam, Ramar Thangam et autres
Extracellular Vesicles Extracellular vesicles (EVs) combined with multifunctional nanomaterials have rapidly emerged as promising platforms for various biomedical applications. In article number 2104783, Heemin Kang, Ki-Bum Lee, and co-workers describe several key challenges and possible nanotechnology-enabled EV applications, such as next-generation EV-based …
us, kr
(code pays fourni par la source)
2022
article
OpenAlex
Letao Yang, Brian Conley, Christopher Rathnam, Hyeon‐Yeol Cho et autres
Biophysical cues, such as nanotopographies of extracellular matrix (ECM), are key cell regulators for direct cell reprogramming. Therefore, high-throughput methods capable of systematically screening a wide range of biophysical cue-regulated cell reprogramming are increasingly needed for tissue engineering and regenerative medicine. Here, …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Letao Yang, Kapil D. Patel, Christopher Rathnam, Ramar Thangam et autres
Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient …
us, kr
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Letao Yang, Brian Conley, Jinho Yoon, Christopher Rathnam et autres
A systematic investigation of stem cell-derived neural interfaces can facilitate the discovery of the molecular mechanisms behind cell behavior in neurological disorders and accelerate the development of stem cell-based therapies. Nevertheless, high-throughput investigation of the cell-type-specific biophysical cues associated with stem cell-derived …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Christopher Rathnam, Letao Yang, Sofia Castro-Pedrido, Jeffrey Luo et autres
Although stem cell therapy holds enormous potential for treating debilitating injuries and diseases in the central nervous system, low survival and inefficient differentiation have restricted its clinical applications. Recently, 3D cell culture methods, such as stem cell–based spheroids and organoids, have demonstrated …
us
(code pays fourni par la source)