Accès ouvert
2025
article
OpenAlex
Yiran Zhang, Brian Buck, Philip A. Barber, Kausik Chatterjee et autres
Importance: Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits. Objective: To determine whether intravenous tenecteplase improves outcomes according to US National Institutes of Health Stroke Scale (NIHSS) score-based definitions of pretreatment disabling deficits. …
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Accès ouvert
2025
article
OpenAlex
Rodica Pop‐Busui, Samuel P. Rosin, Nicole M. Butera, Heidi Krause‐Steinrauf et autres
OBJECTIVE: To describe the prevalence and incidence of electrocardiogram (ECG) abnormalities and ECG-derived cardiovascular autonomic neuropathy (CAN) in the GRADE cohort of adults with type 2 diabetes (T2D) <10 years. RESEARCH DESIGN AND METHODS: Individuals with T2D taking metformin alone were randomly …
us
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Accès ouvert
2025
article
OpenAlex
Daniel S. Hsia, Naji Younes, Alokananda Ghosh, Erin J. Kazemi et autres
OBJECTIVE: To compare rates of and risk factors for hospitalizations among Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants taking metformin and randomly assigned to insulin glargine U-100, glimepiride, liraglutide, or sitagliptin. RESEARCH DESIGN AND METHODS: Intention-to-treat (ITT) (N …
us
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Accès ouvert
2025
article
OpenAlex
José A. Luchsinger, Samuel P. Rosin, Erin J. Kazemi, Naji Younes et autres
Importance: Type 2 diabetes (T2D) is a risk factor for cognitive impairment. Whether the choice of the second-line glucose-lowering treatment added to metformin or glycemic control affects cognitive performance in T2D of relatively short duration (<10 years) is not known. Objective: To …
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Accès ouvert
2025
article
OpenAlex
Deborah J. Wexler, W. Timothy Garvey, Alokananda Ghosh, Erin J. Kazemi et autres
OBJECTIVE: Weight gain with glucose-lowering medications may interfere with effective type 2 diabetes (T2D) management. We evaluated weight change and the effect of weight gain on outcomes over 5 years on four diabetes medications. RESEARCH DESIGN AND METHODS: The Glycemia Reduction Approaches …
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Accès ouvert
2025
article
OpenAlex
Kristina M. Utzschneider, Mark Tripputi, Nicole M. Butera, Andrea Mari et autres
OBJECTIVE: To evaluate how model-based parameters of β-cell function change with glucose-lowering treatment and associate with glycemic deterioration in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: In the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), β-cell …
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Accès ouvert
2025
article
OpenAlex
Shannon D. Smith, M. Mohan Sampath Kumar, John R. Absher
BACKGROUND: Craniocerebral self-inflicted gunshot wounds (SIGSW) are fatal in 90% of individuals, usually before reaching a hospital setting. We report a unique SIGSW survivor's residual neurologic deficits, imaging, neuropsychiatric findings, and improvement in psychosis. CASE PRESENTATION: The patient is a 32-year-old right-handed …
us
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Accès ouvert
2024
article
OpenAlex
Jeffrey S. Gonzalez, Ionut Bebu, Heidi Krause‐Steinrauf, Claire J. Hoogendoorn et autres
OBJECTIVE: We evaluated whether adding basal insulin to metformin in adults with early type 2 diabetes mellitus (T2DM) would increase emotional distress relative to other treatments. RESEARCH DESIGN AND METHODS: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) of …
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2024
article
OpenAlex
Jennifer B. Green, Brendan M. Everett, Alokananda Ghosh, Naji Younes et autres
BACKGROUND: Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2 diabetes. The effects of glucose-lowering medications on cardiovascular outcomes in individuals with type 2 diabetes and low cardiovascular risk are unclear. We investigated cardiovascular outcomes by …
us, pe
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Accès ouvert
2024
article
OpenAlex
W. Timothy Garvey, Robert M. Cohen, Nicole M. Butera, Erin J. Kazemi et autres
OBJECTIVE: To describe the individual and joint associations of baseline factors with glycemia, and also with differential effectiveness of medications added to metformin. RESEARCH DESIGN AND METHODS: Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants (with type 2 diabetes …
us
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Accès ouvert
2024
article
OpenAlex
Mary Ann Banerji, John B. Buse, Naji Younes, Heidi Krause‐Steinrauf et autres
OBJECTIVE: We report mortality outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) among people with type 2 diabetes diagnosed within 10 years and no recent history of cardiovascular events or cancer. RESEARCH DESIGN AND METHODS: Overall mortality …
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Accès ouvert
2024
article
OpenAlex
Andrea Cherrington, Ionut Bebu, Heidi Krause‐Steinrauf, Claire J. Hoogendoorn et autres
OBJECTIVE: To evaluate whether baseline levels of depressive symptoms and diabetes-specific distress are associated with glycemic control in Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), a large randomized controlled trial comparing the metabolic effects of four common glucose-lowering medications …
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