Viktoria Höller

The prospective Austrian hypertrophic cardiomyopathy registry – design, methods and results of the run-in period

Viktoria Santner, Christina Granitz, Martin R. Grübler, Daniel Dalos et autres

The diagnosis and management of hypertrophic cardiomyopathy (HCM) is increasingly complex, and systematic evidence remains sparse. The Austrian HCM registry aims to provide representative real-world data addressing gaps in evidence. Here, we report design, methods and results after one year enrolment. The …

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Prognostic value of circulating glypican-4 in chronic heart failure

Nora Schwegel, Viktoria Höller, Viktoria Santner, David K. Zach et autres

Glypican-4 (GPC-4), an endothelial cell surface protein, is released into the circulation in the context of ischemia, inflammation, neurohumoral activity, and shear stress. This study aimed to investigate the prognostic value of GPC-4 in chronic heart failure. GPC-4 concentrations were determined in …

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Hereditary Transthyretin Amyloidosis in Austria: Clinical, Genetic, and Demographic Insights from a Nationwide Cohort

N Ermolaev, Wolfgang N. Löscher, Nicolas Verheyen, Gerhard Pölzl et autres

Background/Objectives: Hereditary transthyretin amyloidosis (ATTRv) is a heterogeneous multisystem disease caused by pathogenic transthyretin gene (TTR) variants. Increased awareness and availability of disease-modifying therapies have resulted in increased diagnoses, even in previously nonendemic regions. The aim of this study was to update …

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Left ventricular global longitudinal strain and diagnostic yield of genetic testing in hypertrophic cardiomyopathy in a multicenter registry analysis

Viktoria Santner, Viktoria Höller, Maria Ungericht, Nora Schwegel et autres

In this multicenter study we investigated whether echocardiography-derived left ventricular global longitudinal strain (LV GLS), an indicator of myocardial fibrosis, independently predicts a positive genotype in hypertrophic cardiomyopathy (HCM). We performed a cross-sectional analysis including HCM patients with genetic testing results and …

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Prognostic Impact of Gait Speed, Muscle Strength and Muscle Mass in Chronic Heart Failure—A Prospective Cohort Study

Vladimir Cejka, Hermann Riepl, Nora Schwegel, Ewald Kolesnik et autres

Abstract Aims Heart failure (HF) impairs skeletal muscle mass and function, which contributes to reduced physical performance. We investigated the prognostic impact of gait speed (GS), handgrip strength (HG) and appendicular skeletal muscle index (ASMI) on cardiovascular outcomes in a prospective HF …

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Variant cardiac transthyretin amyloidosis presenting as hypertrophic cardiomyopathy with left ventricular outflow tract obstruction: a case report

Viktoria Höller, Viktoria Santner, Johannes Schmid, Andreas Zirlik et autres

Abstract Background Left ventricular outflow tract obstruction (LVOTO) is common in hypertrophic cardiomyopathy (HCM) but has not been reported in hereditary transthyretin amyloidosis (ATTRv). Case summary Here, we describe a 67-year-old male patient with a hypertrophic phenotype who was initially diagnosed with …

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Impact of SGLT2-Inhibitor Therapy on Survival in Patients with Transthyretin Amyloid Cardiomyopathy: Analysis of a Prospective Registry Study

Nora Schwegel, Christina Toferer, David K. Zach, Viktoria Santner et autres

Background: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) represent a high-risk heart failure population with continued unmet therapeutic needs. Sodium–glucose co-transporter 2 inhibitors (SGLT2i) improve cardiovascular outcomes in patients with heart failure across the whole spectrum of ejection fraction, and first evidence regarding …

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Prevalence and outcome of coronary artery disease in cardiac amyloidosis: A retrospective Austrian multicenter study PC44 (#356)

Maria Ungericht, Moritz Messner, Christian Puelacher, Thomas J. Schuetz et autres

The Prognostic Value of Right Ventricular Function in Patients with Chronic Heart Failure—A Prospective Study

Nora Schwegel, David K. Zach, Alexander Peikert, Viktoria Santner et autres

Background: In patients with stable chronic heart failure with a reduced ejection fraction (HFrEF), left ventricular ejection fraction (LVEF) provides limited prognostic value, especially in patients with moderately to severely reduced LVEF. Echocardiographic parameters of right ventricular function may be associated with …

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Prevalence and Prognostic Impact of Bone Disease in Chronic Heart Failure with Reduced Ejection Fraction

Nicolas Verheyen, Johannes Schmid, Ewald Kolesnik, Nora Schwegel et autres

AIMS: Chronic heart failure is associated with a bone-catabolic state and increases the risk of osteoporosis and fractures. Prospective studies investigating the clinical relevance of bone disease in heart failure are lacking. We aimed to assess the prevalence and prognostic impact of …

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Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy—The Graz Hypertrophic Cardiomyopathy Registry

Viktoria Höller, Heidelis A. Seebacher, David K. Zach, Nora Schwegel et autres

Accumulating evidence suggests that individuals with sarcomeric hypertrophic cardiomyopathy (HCM) carrying MYH7 mutations may have a worse prognosis than MYBPC3 mutation carriers. Myocardial deformation analysis is superior to standard echocardiography in detecting subtle myocardial dysfunction and scar formation, but studies evaluating the …

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Austria – Europe’s problem child in the year 2000

Viktoria Höller

Die österreichische Koalitionsregierung zwischen der konservativen Partei, ÖVP, und der extrem rechten Partei, FPÖ im Jahr 2000 und die darauffolgenden Sanktionsmaßnahmen der 14 EU Mitgliedstaaten, haben international für Aufruhr gesorgt. Vor allem der damalige Parteichef der FPÖ Jörg Haider, ist immer wieder …