Jiaying Lu

Caudate-Predominant Striatal Dopaminergic Deficit Distinguishes Behavioral Variant of Frontotemporal Dementia With Parkinsonism From Other Parkinsonian Syndromes

L L Feng, Wen Liu, Yixin Zhao, Kun‐Wang Chan et autres

BACKGROUND: Behavioral variant of frontotemporal dementia (bvFTD) often presents with parkinsonism. Our study aimed to characterize the dopaminergic deficit pattern in bvFTD-parkinsonism (bvFTD-P) using dopamine transporter (DAT) positron emission tomography (PET) and to assess its potential value in differentiating bvFTD-P from progressive …

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Clinical Evaluation of the Revised Biological and Clinical Staging Criteria for Alzheimer Disease in China

Zi-yi Wang, Jia-Wei Xin, Mingyu Wang, Shufen Chen et autres

BACKGROUND AND OBJECTIVES: The 2024 revised criteria introduced an integrated framework for staging Alzheimer disease (AD) across biological and clinical dimensions. However, how this criterion characterizes clinical and biological features in populations outside the original development setting, particularly in non-Western and specialized …

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Brain Metabolic Signatures of Amyloid‐ β and Tau Pathology in Corticobasal Syndrome: A Multimodal Biomarker Study

Xinyi Li, Jiaying Lu, Qi Shen, Yi‐Xin Zhao et autres

Abstract Background Corticobasal syndrome (CBS) may arise from heterogeneous neuropathological substrates, including corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD), and biomarker‐based stratification has therefore become central to its characterization in vivo . In a large CBS cohort, we …

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Diagnostic impact of tau versus amyloid PET in patients with cognitive symptoms

Jia-Wei Xin, Zi-yi Wang, Yu Guo, Ke-Liang Chen et autres

The diagnostic efficacy of tau positron emission tomography (PET) relative to amyloid PET in memory clinic settings remains underexplored. In this study, 1008 consecutive Han Chinese individuals with cognitive impairments were recruited between March 2020 and July 2025. They underwent comprehensive clinical …

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A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease

Yi-Xiang Wang, Aocheng Zhong, Qian Xu, Haolin Huang et autres

Quantitative PET underpins diagnosis and treatment monitoring in neurodegenerative disease, yet systematic biases between PET-MRI and PET-CT preclude threshold transfer and cross-site comparability. We developed and validated the first unified, anatomically guided deep-learning framework to harmonize PET-MRI quantification to PET-CT standards across …

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Exploring the Role of TSPO-PET Imaging Among MRI-Negative Patients with Temporal Lobe Epilepsy: From the Perspective of Heterogeneity

Yuncan Chen, Jing Wang, Shimin Xu, Q Wang et autres

Background/Objectives: This study explored the heterogeneous distribution pattern of translocator protein 18kDa (TSPO)-PET/MRI using radioligand [18F] DPA-714 in temporal lobe epilepsy patients and identified clinical factors influencing imaging outcomes. Methods: The TSPO imaging in individual patient was evaluated with both visual reading …

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Stratifying amyloid burden in early Alzheimer’s disease using cascaded attention-guided vision transformer using [¹⁸F]Florbetapir PET

Chenhan Wang, Huiwei Zhang, Fangyang Jiao, Fei Huang et autres

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Utility of 18F-Florzolotau PET as a prognostic and monitoring biomarker in a memory clinic cohort

Jiaying Lu, Jie Wang, Huiwei Zhang, Jie Wu et autres

BACKGROUND: Tau PET is increasingly recognized for its prognostic and disease-monitoring value in Alzheimer’s disease (AD); however, real-world evidence in heterogeneous memory clinic populations remains limited, especially for novel tau positron emission tomography (PET) with 18F-Florzolotau. METHODS: We prospectively enrolled 340 individuals …

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Florzolotau Tau PET for the prediction of clinical progression in the Shanghai Memory Study

Jiaying Lu, J. Wang, Huiwei Zhang, Jie Wu et autres

BACKGROUND: Clinical-biological diagnosis of Alzheimer's disease (AD) is gaining increasing recognition. Beyond diagnosis, biological profiles can be of great benefit for disease monitoring and prognosis, although evidence from real-world memory clinics is still limited. METHOD: 211 subjects with cognitive concerns and 31 …

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Clinical features, biomarker profile and neuroimaging characteristics in patients from memory clinic in China: The Shanghai Memory Study

Jie Wang, Xiaoxi Ma, Jiaying Lu, Jie Wu et autres

BACKGROUND: Tremendous advancement has been made in biomarker assessment, molecular neuroimaging and disease modifying therapy in neurodegenerative cognitive disorders. China is lacking clinical cohorts that deeply profile patients from memory clinic that integrate both comprehensive clinical assessment and multi-modal biomarker examinations. METHODS: …

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Florzolotau Tau PET for the prediction of clinical progression in the Shanghai Memory Study

Jiaying Lu, Jie Wang, Huiwei Zhang, Jie Wu et autres

BACKGROUND: Clinical-biological diagnosis of Alzheimer's disease (AD) is gaining increasing recognition. Beyond diagnosis, biological profiles can be of great benefit for disease monitoring and prognosis, although evidence from real-world memory clinics is still limited. METHOD: 211 subjects with cognitive concerns and 31 …

cn (code pays fourni par la source)

Diagnostic Utility of 18F‐Florzolotau PET Imaging in Patients with Cognitive Symptoms

Mei Cui, Jiawei Xin, Y. P. Guo, Ziyi Wang et autres

BACKGROUND: The clinical utility of 18F-Florzolotau PET imaging in evaluating unselected patients presenting with cognitive complaints in a real-world memory clinic setting remains unclear. This cohort study was designed to comprehensively evaluate the diagnostic accuracy, reclassification impact, and influence on diagnostic confidence …

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