Laurence Chaperot

Irradiation‐Induced CD62L Shedding in Human Plasmacytoid Dendritic Cells Depends on ADAM17 and p38 MAPK

Estelle Leplus, Jamila Kacher, Dalil Hannani, Guillaume Vayssière et autres

Plasmacytoid dendritic cells (PDCs) represent a crucial bridge between innate and adaptive immunity as they can recognise viruses and viral-infected cells, secrete type I interferon and prime naive T-cell responses. Like naive T cells, PDCs express CD62L, an essential molecule involved in …

de, fr (code pays fourni par la source)

SEC Injectable Solution Preserves Activated T Cells in Hypothermic Condition

Anthony Maino, Olivier Manches, Laura Rodríguez, Zoran Ivanović et autres

fr, se (code pays fourni par la source)

Personal exposure to air pollutants and immune system biomarkers in pregnant women

Anouk Marsal, Laurene Frau, Laurence Chaperot, Ines Amine et autres

Abstract The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO 2 ), particulate matter with an aerodynamic …

fr, us (code pays fourni par la source)

Soluble VE-cadherin as a biomarker of response to immunotherapy by anti-PD1 in metastatic melanoma

Clémentine Broche, Khémary Um, Isabelle Vilgrain, Stéphane Mouret et autres

fr (code pays fourni par la source)

Identification of immunogenic HLA-A*02:01 epitopes associated with HCC for immunotherapy development

Anthony Maino, Ekaterina Bourova-Flin, Thomas Decaens, Saadi Khochbin et autres

BACKGROUND: HCC is the most common form of primary liver cancer, and despite recent advances in cancer treatment, it remains associated with poor prognosis and a lack of response to conventional therapies. Immunotherapies have emerged as a promising approach for cancer treatment, …

fr (code pays fourni par la source)

Les motifs glycans dérivés du mélanome détournent les cellules dendritiques par liaison des récepteurs lectine de type C (CLR)

Camille Niveau, E. Sosa Cuevas, Benoît Roubinet, Mylène Pezet et autres

fr (code pays fourni par la source)

Development of a New Off-the-Shelf Plasmacytoid Dendritic Cell–Based Approach for the Expansion and Characterization of SARS-CoV-2–Specific T Cells

Anthony Maino, Axelle Amen, Joël Plumas, Lucie Bouquet et autres

Global vaccination against COVID-19 has been widely successful; however, there is a need for complementary immunotherapies in severe forms of the disease and in immunocompromised patients. Cytotoxic CD8+ T cells have a crucial role in disease control, but their function can be …

fr (code pays fourni par la source)

Melanoma tumour‐derived glycans hijack dendritic cell subsets through C ‐type lectin receptor binding

Camille Niveau, Eleonora Sosa Cuevas, Benoît Roubinet, Mylène Pezet et autres

Dendritic cell (DC) subsets play a crucial role in shaping anti-tumour immunity. Cancer escapes from the control immune system by hijacking DC functions. Yet, bases for such subversion are only partially understood. Tumour cells display aberrant glycan motifs on surface glycoproteins and …

fr (code pays fourni par la source)

P-215 Variations journalières et saisonnières des concentrations circulantes de sérotonine et de cortisol chez les donneurs volontaires; liens avec le climat et le stress lié au don de sang

Olivier Manches, Johanna Lepeule, Philippe Saas, Rémy Slama et autres

fr (code pays fourni par la source)

Data from Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment

Jamila Kacher, Olivier Manches, Caroline Aspord, Hervé Sartelet et autres

In neuroblastoma, MYCN amplification is associated with sparse immune infiltrate and poor prognosis. Dendritic cells (DC) are crucial immune sentinels but their involvement in neuroblastoma pathogenesis is poorly understood. We observed that the migration of monocytes, myeloid and plasmacytoid DC induced by …

Data from Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment

Jamila Kacher, Olivier Manches, Caroline Aspord, Hervé Sartelet et autres

In neuroblastoma, MYCN amplification is associated with sparse immune infiltrate and poor prognosis. Dendritic cells (DC) are crucial immune sentinels but their involvement in neuroblastoma pathogenesis is poorly understood. We observed that the migration of monocytes, myeloid and plasmacytoid DC induced by …

Maternal imprinting and determinants of neonates’ immune function in the SEPAGES mother-child cohort

Olivier Manches, Khémary Um, Anne Boudier, Yasmina Maddouri et autres

Introduction: Immune function in pregnancy is influenced by host-specific and environmental factors. This may impact fetal immune development, but the link between maternal and neonatal immune function is still poorly characterized. Here, we investigate the relationship between maternal and neonatal immune function, …

fr (code pays fourni par la source)