M. E. Bierwagen

Contents, Vol. 6, 1971 / Foreword

J.N. Barker, J.C. de Valois, J.P.C. Peperkamp, J.P. Schadé et autres

Effect of Gram-Negative Endotoxin on Cerebral Circulation

J P Buyniski, Maria Isabel Estrela Smith, M. E. Bierwagen

Research Articles| January 24 2008 Effect of Gram-Negative Endotoxin on Cerebral Circulation Subject Area: Neurology and Neuroscience J.P. Buyniski; J.P. Buyniski Cerebrovascular and Cardiovascular Research Section, Bristol Laboratories, Syracuse, N.Y. Search for other works by this author on: This Site PubMed Google …

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Antitussive properties of butorphanol.

R L Cavanagh, Jonas A. Gylys, M. E. Bierwagen

Butorphanol (levo-N-cyclobutylmethyl-3, 14-dihydroxy morphinan), a potent analgetic agent of the narcotic antagonist type with a low abuse potential in laboratory animals, was evaluated for antitussive activity in unanesthetized guinea-pigs and dogs. Subcutaneously, it was over 100 times more active than codeine, dextromethorphan …

The pharmacology of butorphanol, a 3,14-dihydroxymorphinan narcotic antagonist analgesic.

Anthony W. Pircio, Jonas A. Gylys, R L Cavanagh, J P Buyniski et autres

Butorphanol, a new, totally synthetic morphinan, which is chemically related to naloxone, has been demonstrated to have both analgesic and narcotic antagonist properties. In rodent antiwrithing analgesic tests, butorphanol was 4 to 30 times more potent than morphine and dl-pentazocine, respectively. As …

Pharmacology of a potent, new antithrombotic agent, 6-methyl-1,2,3,5-tetrahydroimidazo[2, 1-b] quinazolin-2-one hydrochloride monohydrate.

John Fleming, J P Buyniski, R L Cavanagh, M. E. Bierwagen

A new method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat

Anthony W. Pircio, Cosmo T. Fedele, M. E. Bierwagen

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ChemInform Abstract: POTENTIAL ANTIFERTILITY AGENTS PART 4, BIOLOGICAL PROPERTIES OF DIASTEREOISOMERIC 4‐ARYL‐2‐METHYLCYCLOHEXANECARBOXYLIC ACIDS AND RELATED COMPOUNDS

R. R. Crenshaw, G. M. LUKE, T. A. JENS, R. A. Partyka et autres

Abstract Auf dem im Formelschema angegebenen Wegen werden verschiedene 4‐(p‐Methoxyphenyl)‐2‐methyl‐cyclohexancarbonsäuren und verwandte Verbindungen dargestellt, deren Fruchtbarkeit‐hemmende, östrogene, hypocholesterinämi= sche und Gonadotropin‐inhibierende Wirkung untersucht wird.

Potential antifertility agents. 4. Biological properties of diastereoisomeric 4-aryl-2-methylcyclohexanecarboxylic acids and related compounds

R. R. Crenshaw, George M. Luke, T. A. JENKS, R. A. Partyka et autres

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential antifertility agents. 4. Biological properties of diastereoisomeric 4-aryl-2-methylcyclohexanecarboxylic acids and related compoundsR. R. Crenshaw, George M. Luke, Thomas A. Jenks, Richard A. Partyka, Gabriel Bialy, and Max E. BierwagenCite this: J. Med. Chem. 1973, 16, 7, 813–823Publication Date …

ChemInform Abstract: VERBINDUNGEN MIT EINER MOEGLICHEN EMPFAENGNIS VERHUETENDEN WIRKUNG 3. MITT. SUBSTITUIERTE DIBENZOTHIOPHENCARBONSAEUREN UND IHRE DERIVATE

R. R. Crenshaw, G. M. LUKE, T. A. JENKS, G. Bialy et autres

Abstract Aus der Cyclohexenoncarbonsäure (I) erhält man mit alkalischem Wasserstoffperoxid das Epoxid (II), das mit 3‐Methoxy‐thiophenol (III) zum Vinylsulfid (IV) reagiert.

OTOTOXICITY STUDIES WITH BB-K8, A NEW SEMISYNTHETIC AMINOGLYCOSIDE ANTIBIOTIC

J. G. REIFFENSTEIN, S. W. HOLMES, M. E. Bierwagen

BB-K 8, a new semisynthetic aminoglycosidic antibiotic, was evaluated for ototoxicity, nephrotoxicity and neuromuscular blocking activity in the cat. As a reference, kanamycin was tested by the same experimental methods. Employing equivalent doses in terms of the free base and 7 days …

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Potential antifertility agents. 3. Substituted dibenzothiophenecarboxylic acids and derivatives

R. R. Crenshaw, G. M. LUKE, T. A. JENKS, G. Bialy et autres

The syntheses of 37 derivatives of 4-methyldibenzothiophene-3carboxylic acid were reported. Compounds were assayed for their estrogenic and antifertility activities in female mice and rats. In general cis isomers were more active than the trans. In certain postcoital dosing regimens, 2 analogs were …

CEREBRAL AND CORONARY VASCULAR EFFECTS OF A SYMMETRICAL N,N'-DISUBSTITUTED HEXAHYDRODIAZEPINE

J. P. Buyniski, Mercedes Losada, M. E. Bierwagen, R.W. Gardier