Patrick J. Mueller

Overexpression of brain-derived neurotrophic factor (BDNF) in the rostral ventrolateral medulla (RVLM) increases blood pressure in normotensive rats

Anna Park, Benedek Erdös, Noreen Rossi, Patrick J. Mueller

Cardiovascular disease (CVD) remains the leading cause of death, and people who remain sedentary are more likely to die from CVD than from other preventable risk factors. High blood pressure is also a risk factor for CVD, and sedentary individuals are more …

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Impact of chronic exercise and ovarian hormones on resting sympathetic nerve activity and sympathetic transduction in female rats

Gwendolyn Adoteye, Jennifer Vranish, Patrick J. Mueller

Elevated sympathetic nerve activity (SNA) and a sedentary lifestyle both increase the risk of cardiovascular diseases. During reproductive ages, women have lower SNA compared to age-matched men, suggesting a cardioprotective role of ovarian hormones. In contrast, our previous studies have shown that …

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Action potential identification in rodent sympathetic nerve recordings using a wavelet-based approach

Arman Rajaei, Mehdi Ahmadian, Glen E. Foster, Klaske van Heusden et autres

The sympathetic nervous system is a master regulator of cardiovascular function. Over the last two decades there has been renewed interest in identifying the underlying behavior of post-ganglionic sympathetic nerves. By using wavelet-based approaches to isolate underlying action potentials (APs) within multi-unit …

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Mosunetuzumab (Mosun) or glofitamab (Glofit) in combination with golcadomide (Golca) demonstrates a manageable safety profile and encouraging efficacy in patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL)

Charalambos Babis Andreadis, Irit Mazza Avivi, Neta Goldschmidt, William M. Townsend et autres

Abstract Background: Mosun and Glofit, both CD20xCD3 T-cell engaging bispecific antibodies, have demonstrated high response rates and manageable safety in patients (pts) with R/R follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Golca, a CELMoDTM agent, drives the closed active conformation …

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Safety and efficacy of elranatamab in combination with iberdomide in patients with relapsed or refractory multiple myeloma: Results from the phase 1b MagnetisMM-30 trial

Attaya Suvannasankha, Jonathan L. Kaufman, Ashraf Z. Badros, Michel Pavic et autres

Abstract Background Elranatamab (ELRA), a B-cell maturation antigen (BCMA)-CD3 bispecific antibody, induced deep and durable responses with a manageable safety profile in the phase 2 registrational MagnetisMM-3 study (NCT04649359) in patients (pts) with relapsed or refractory multiple myeloma (RRMM) (Prince et al, …

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The impact of a 6-month structured dance training program on resting blood pressure and resting heart rate in MCI patients

Yves Lading, Manfred Kunz, Anita Höekelmann, Stefanie Schreiber et autres

Abstract Background Arterial hypertension is a major risk factor for neurodegenerative diseases. Mild cognitive impairment (MCI) is associated with a high conversion rate to clinically manifest dementia, characterized by impaired daily functioning. Due to the lack of causal therapeutic approaches, there is …

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Sympathetic Transduction in Sprague-Dawley Rats: A Methodological Tool for Translational Studies

Jennifer R. Vranish, Benjamin E. Young, Paul J. Fadel, Patrick J. Mueller

Introduction: Cardiovascular disease (CVD) is the leading cause of death in the United States. CVD is associated with elevations in sympathetic nerve activity (SNA), which impact the vasculature both acutely and chronically. In human studies, the ability of SNA to vasoconstrict has …

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Localization of Brain-Derived Neurotrophic Factor-Related Genes in the Rostral Ventrolateral Medulla of Male Sprague-Dawley Rats using RNAscope

Niella Amore, Emily L. Henson, Patrick J. Mueller

Cardiovascular disease (CVD) is the leading cause of death in the US, and a large risk factor for CVD a sedentary lifestyle. CVD is often associated with increased activity of the sympathetic nervous system, which regulates blood pressure via vasoconstriction. Sedentary animals …

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Systolic and diastolic dysfunction is exacerbated by age and spinal cord injury in male and female mice with central nervous system serotonin deficiency

Qingchao Qiu, Dragana Komnenov, Mirabela Hali, Charles S. Chung et autres

Abstract The present study was designed to explore whether the depletion of serotonin (5‐HT) in the central nervous system (CNS 5‐HT ) leads to systolic and diastolic dysfunction and whether this dysfunction is exacerbated by sex, age and spinal cord injury. Echocardiographic …

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Exercise intensity shapes acute and prolonged immune and extracellular vesicle responses in older adults

Alejandra P. Garza, Lorena Morton, Anna-Lena Motsch, Christian Puta et autres

Abstract Regular physical activity is a cornerstone of healthy aging, offering a wide range of benefits, including the modulation of immune regulation and reduction of chronic inflammation. With aging closely linked to persistent, low-grade inflammation, i.e. inflammaging, the effects of exercise intensity …

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Acute intermittent hypoxia elicits sympathetic neuroplasticity independent of peripheral chemoreflex activation and spinal cord tissue hypoxia in a rodent model of high-thoracic spinal cord injury

Mehdi Ahmadian, Erin Erskine, Liisa Wainman, Oliver H. Wearing et autres

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The left ventricle increases contractility in response to baroreceptor unloading, which is sympathetically mediated in the anesthetized rat

Liam C. Stewart, Liisa Wainman, Mehdi Ahmadian, Jennifer S. Duffy et autres

This study empirically demonstrates a sympathetically mediated increase in LV contractility in response to baroreceptor unloading using a load-independent index of cardiac contractility in the anesthetized rat.

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