Accès ouvert
2023
article
OpenAlex
Kellianne D. Alexander, Shankar Ramachandran, Kasturi Biswas, Christopher M. Lambert et autres
The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse elimination and its timing remain elusive. We show that the transcriptional regulator DVE-1, which shares homology with special AT-rich sequence-binding (SATB) family members previously …
us, gb, ca
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Accès ouvert
2022
preprint
OpenAlex
Kellianne D. Alexander, Shankar Ramachandran, Kasturi Biswas, Christopher M. Lambert et autres
Abstract An important step in brain development is the remodeling of juvenile neural circuits to establish mature connectivity. The elimination of juvenile synapses is a critical step in this process; however, the molecular mechanisms directing synapse elimination activities and their timing are …
us, gb, ca
(code pays fourni par la source)
Accès ouvert
2022
erratum
OpenAlex
Devyn Oliver, Shankar Ramachandran, Alison Philbrook, Christopher M. Lambert et autres
[This corrects the article DOI: 10.1371/journal.pgen.1010016.].
Accès ouvert
2022
article
OpenAlex
Devyn Oliver, Shankar Ramachandran, Alison Philbrook, Christopher M. Lambert et autres
The functional properties of neural circuits are defined by the patterns of synaptic connections between their partnering neurons, but the mechanisms that stabilize circuit connectivity are poorly understood. We systemically examined this question at synapses onto newly characterized dendritic spines of C. …
us
(code pays fourni par la source)
Accès ouvert
2021
peer-review
OpenAlex
Shankar Ramachandran, Navonil Banerjee, Raja Bhattacharya, Jeremy Florman et autres
Investigation of neuromodulatory control of ethologically conserved area-restricted food search behavior shows that NLP-12 stimulation of the head motor circuit promotes food searching through the previously uncharacterized CKR-1 GPCR.
us, be
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Devyn Oliver, Shankar Ramachandran, Alison Philbrook, Christopher M. Lambert et autres
Abstract The functional properties of neural circuits are defined by the patterns of synaptic connections between their partnering neurons, but the mechanisms that stabilize circuit connectivity are poorly understood. We systemically examined this question at synapses onto newly characterized dendritic spines of …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Shankar Ramachandran, Navonil Banerjee, Raja Bhattacharya, Michele L. Lemons et autres
SUMMARY Neuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks. Here we show that the C. elegans NLP-12 neuropeptide …
us, be
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Alison Philbrook, Shankar Ramachandran, Christopher M. Lambert, Devyn Oliver et autres
In neural circuits, individual neurons often make projections onto multiple postsynaptic partners. Here, we investigate molecular mechanisms by which these divergent connections are generated, using dyadic synapses in C. elegans as a model. We report that C. elegans nrx-1/neurexin directs divergent connectivity …
us
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Accès ouvert
2018
peer-review
OpenAlex
Alison Philbrook, Shankar Ramachandran, Christopher M. Lambert, Devyn Oliver et autres
Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Belinda Barbagallo, Alison Philbrook, Denis Touroutine, Navonil Banerjee et autres
Establishing and maintaining the appropriate number of GABA synapses is key for balancing excitation and inhibition in the nervous system, though we have only a limited understanding of the mechanisms controlling GABA circuit connectivity. Here, we show that disrupting cholinergic innervation of …
us
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Accès ouvert
2014
article
OpenAlex
Raja Bhattacharya, Denis Touroutine, Belinda Barbagallo, Jason R. Climer et autres
An organism's ability to thrive in changing environmental conditions requires the capacity for making flexible behavioral responses. Here we show that, in the nematode Caenorhabditis elegans, foraging responses to changes in food availability require nlp-12, a homolog of the mammalian neuropeptide cholecystokinin …
us
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Accès ouvert
2012
article
OpenAlex
Sohan Punia, Kyle K. Rumery, Elizabeth A. Yu, Christopher M. Lambert et autres
Insulinoma-associated protein (IA)-2 and IA-2β are transmembrane proteins involved in neurotransmitter secretion. Mice with targeted disruption of both IA-2 and IA-2β (double-knockout, or DKO mice) have numerous endocrine and physiological disruptions, including disruption of circadian and diurnal rhythms. In the present study, …
us
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