Sarah Vascellari

Cranberry Polyphenol Extract (CPE) Oral Rinse Improves Salivary Microbiome in 6-n-Propylthiouracil (PROP) Non-Tasters and Palatability of Aronia Juice

Katrina Nguyen-DeMary, Sarah Vascellari, Mariano Mastinu, Melania Melis et autres

Sensitivity to the bitterness of 6-n-propylthiouracil (PROP) is controlled by variations in the TAS2R38 gene. This phenotype is often used as a marker for individual differences in taste perception. Previous findings show that PROP taster status is associated with differences in the …

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Brain-Only Versus GI-Only Synucleinopathy: A Comprehensive Autopsy Study With Both IHC and SAA

Christina D. Orru, Thomas G. Beach, Charles H. Adler, Holly A. Shill et autres

Braak and others have proposed that Lewy body pathology (LBP) in Parkinson's disease (PD) may arise not only in the brain but alternatively from an initial site in the gastrointestinal (GI) tract with subsequent passage to the central nervous system CNS through …

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Beyond One-Size-Fits-All: Addressing Methodological Constraints in Novel Antimicrobials Discovery

Silvia Puxeddu, Serena Canton, Alessandra Scano, Ilenia Delogu et autres

Background: Antimicrobial resistance is a growing global health concern that requires multiple strategies to be tackled effectively. While the discovery of new antimicrobial molecules is essential, the repurposing of existing compounds also plays a significant role. Standard methods to evaluate antimicrobial efficacy, …

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Age-related neuroinflammation and exacerbated immune responses in PINK1 and PARK2 knockout mice with experimental autoimmune encephalomyelitis

Davide Cossu, Sachiko Noda, Shigeto Sato, Kazumasa Yokoyama et autres

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A same day α-synuclein RT-QuIC seed amplification assay for synucleinopathy biospecimens

Sabiha Parveen, Parvez Alam, Christina Doriana Orru, Sarah Vascellari et autres

Parkinson's disease (PD), dementia with Lewy bodies (DLB), and other synucleinopathies are characterized by the accumulation of abnormal, self-propagating aggregates of α-synuclein. RT-QuIC or seed amplification assays are currently showing unprecedented diagnostic sensitivities and specificities for synucleinopathies even in prodromal phases years …

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Physico-Chemical Investigation and Antimicrobial Efficacy of Ozonated Oils: The Case Study of Commercial Ozonated Olive and Sunflower Seed Refined Oils

Silvia Puxeddu, Alessandra Scano, Mariano Andrea Scorciapino, Ilenia Delogu et autres

Drug resistance represents one of the great plagues of our time worldwide. This largely limits the treatment of common infections and requires the development of new antibiotics or other alternative approaches. Noteworthy, the indiscriminate use of antibiotics is mostly responsible for the …

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Physico-chemical investigation and antimicrobial efficacy of ozonated oils. The case study of commercial ozonated olive and sunflower seed refined oils

Silvia Puxeddu, Alessandra Scano, Mariano Andrea Scorciapino, Ilenia Delogu et autres

Drug-resistance represents one of the great plagues of our time worldwide, largely limiting the treatment of common infections, and accounting for the urge in the development of new antibiotics or other alternative approaches. Noteworthy, the indiscriminate use of antibiotics is mostly responsible …

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α-Synuclein seeding activity in duodenum biopsies from Parkinson’s disease patients

Sarah Vascellari, Christina Doriana Orru, Bradley R. Groveman, Sabiha Parveen et autres

Abnormal deposition of α-synuclein is a key feature and biomarker of Parkinson's disease. α-Synuclein aggregates can propagate themselves by a prion-like seeding-based mechanism within and between tissues and are hypothesized to move between the intestine and brain. α-Synuclein RT-QuIC seed amplification assays …

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Real-Time Quaking- Induced Conversion Assays for Prion Diseases, Synucleinopathies, and Tauopathies

Sarah Vascellari, Christina Doriana Orru, Byron W. Caughey

forms of prion, α-synuclein (αSyn), or tau proteins that cause neurodegeneration and represent hallmarks of these disorders. A main challenge in the management of these diseases is the accurate detection and differentiation of these abnormal proteins during the early stages of disease …

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Parkinson’s Disease: A Prionopathy?

Sarah Vascellari, Aldo Manzin

The principal pathogenic event in Parkinson's disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a …

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Gut microbiota markers associated with obesity and overweight in Italian adults

Vanessa Palmas, Silvia Pisanu, Veronica Madau, Emanuela Casula et autres

In the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI = 36.6 ± 6.0; F/M = 40/6) was …

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Clinical Phenotypes of Parkinson’s Disease Associate with Distinct Gut Microbiota and Metabolome Enterotypes

Sarah Vascellari, Marta Melis, Vanessa Palmas, Silvia Pisanu et autres

Parkinson’s disease (PD) is a clinically heterogenic disorder characterized by distinct clinical entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non-tremor dominant (non-TD) with akinetic-rigid features (AR). Different pathophysiological mechanisms may affect the onset of motor manifestations. …

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