Ivan B. Lobov

The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells

Ron A. Deckelbaum, Ivan B. Lobov, Eunice Cheung, Gábor Halász et autres

Angiogenesis is largely driven by motile endothelial tip-cells capable of invading avascular tissue domains and enabling new vessel formation. Highly responsive to Vascular Endothelial Growth-Factor-A (VEGFA), endothelial tip-cells also suppress angiogenic sprouting in adjacent stalk cells, and thus have been a primary …

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The Effect of Soluble Recombinant Protein Dll4-Fc on the Functional Activity of Endothelial Cells In Vitro and Vascularization In Vivo

Julia I. Khorolskaya, О. И. Александрова, И. А. Самусенко, Natalia Mikhailova et autres

Abstract Restoration of the microvasculature system is necessary for wound healing. Increased angiogenesis in damaged tissue can positively affect the speed and quality of its recovery. The paper analyzes the effect of the soluble recombinant protein Dll4-Fc on the functional activity of …

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Влияние растворимого рекомбинантного белка Dll4-Fc на функциональную активность эндотелиоцитов in vitro и васкуляризацию in vivo

Ю. И. Хорольская, О. И. Александрова, И. А. Самусенко, Н. А. Михайлова et autres

The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions

Ivan B. Lobov, Natalia Mikhailova

BACKGROUND: Retina is the highest oxygen-demanding and vascularized tissue in the body. Retinal development and function require proper vascularization and blood vessel function and integrity. Dll4 is most prominently expressed in the endothelium of angiogenic blood vessels and in quiescent arteries and …

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Issledovanie vliyaniya rastvorimogo rekombinantnogo belka DLL4-FC na funktsional'nuyu aktivnost' endoteliotsitov v razlichnykh usloviyakh kul'tivirovaniya

Yu. I Khorol'skaya, Oksana I. Aleksandrova, N. M. Yudintseva, Ivan B. Lobov et autres

Blockade of Apelin Receptor (APJ) can inhibit developmental retinal vessel outgrowth in pups and promote normal revascularization and reduce pathological neovascularization in OIR model in mice

Eunice Cheung, Panayiotis E. Stevis, Yonaton Ray, Stanley J. Wiegand et autres

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Effects of Inhibition of PDGF Family Ligands and Receptors on Pericytes and Blood Vessel Morphology in the Developing Mouse Retina

R. Wudali, Eunice Cheung, George D. Yancopoulos, Carl Romano et autres

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Inhibiting Platelet Derived Growth Factor Receptor β (PDGFRβ) affects vessel morphology and growth of developing retinal vessels, and induces leucocyte infiltration in mice

Eunice Cheung, Stanley J. Wiegand, Jingtai Cao, Carmelo Romano et autres

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An assessment of the angiogenic effects of VEGF-A and ANGPTL4 in the mouse retina.

R. Wudali, Eunice Cheung, Angela Sun, Laura Winters et autres

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Effects of combined inhibition of VEGF and Ang2 using aflibercept (VEGF Trap) and anti-Ang2 antibody on the developing retinal angiogenesis in mice.

Eunice Cheung, Ivan B. Lobov, Jingtai Cao, George Yancopaulos et autres

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Inhibiting Platelet Derived Growth Factor Receptor β (PDGFRβ) reduces pericytes coverage and effects vessel morphology and growth in developing retinal vessels in pups but not mature vessels in adult mice

Eunice Cheung, Ivan B. Lobov, George D. Yancopoulos, Stanley J. Wiegand

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Conditionals by inversion provide a universal method for the generation of conditional alleles

Aris N. Economides, David Frendewey, Peter Yang, Melissa G. Dominguez et autres

Conditional mutagenesis is becoming a method of choice for studying gene function, but constructing conditional alleles is often laborious, limited by target gene structure, and at times, prone to incomplete conditional ablation. To address these issues, we developed a technology termed conditionals …

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