Milena Radeva

The PVD-B65 risk score for interstitial lung disease and pulmonary hypertension: External validation using the PVDOMICS cohort

Shameek K. Gayen, Jay Pescatore, Lijo Illipparambil, Seyedmohammad Pourshahid et autres

Background Validated prognostication tools for patients with pulmonary hypertension related to interstitial lung disease (PH-ILD) are lacking. Our group developed and internally validated a novel one-year mortality risk score for patients with pulmonary hypertension related to chronic lung disease, termed PVD-B65. Here, …

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Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease

Darin T. Rosen, Todd M. Kolb, Stephen C. Mathai, Karthik S. Suresh et autres

BACKGROUND: Right ventricular (RV) maladaptation to elevated pulmonary afterload is the primary determinant of outcomes in pulmonary artery (PA) hypertension; however, the pathobiological mechanisms underlying RV decompensation remain poorly understood. METHODS: We performed global untargeted metabolomics on plasma from 55 patients who …

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Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula

Yong He, Guo Wei, Tom Greene, Peter B. Imrey et autres

Abstract The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations of wall shear stress (WSS) with subsequent AVF remodeling and clinical maturation using regression models in this prospective cohort study. Participants underwent duplex ultrasound at postoperative Day …

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Alterations in Mitochondrial Function in Pulmonary Vascular Diseases

Samar Farha, Kewal Asosingh, Paul M. Hassoun, John Barnard et autres

Aims: Alterations of mitochondrial bioenergetics and arginine metabolism are universally present and mechanistically linked to pulmonary arterial hypertension (PAH), but there is little knowledge of arginine metabolism and mitochondrial functions across the different pulmonary hypertension (PH) groups. We hypothesize that abnormalities in …

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Health-Related Quality of Life Across the Spectrum of Pulmonary Hypertension

Aparna Balasubramanian, A. Brett Larive, Evelyn M. Horn, Hilary M. DuBrock et autres

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Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension

Megan M. Lowery, Nicholas S. Hill, Lu Wang, Erika B. Rosenzweig et autres

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Mitochondrial Dysfunction Across Pulmonary Vascular Diseases

Samar Farha, PM Hassoun, Andrew Reichard, Nicholas Wanner et autres

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Association of Shear Stress with Subsequent Lumen Remodeling in Hemodialysis Arteriovenous Fistulas

Yong He, Yan-Ting Shiu, Peter B. Imrey, Milena Radeva et autres

BACKGROUND: Blood flow-induced wall shear stress is a strong local regulator of vascular remodeling, but its effects on arteriovenous fistula (AVF) remodeling are unclear. METHODS: In this prospective cohort study, we used computational fluid dynamics simulations and statistical mixed-effects modeling to investigate …

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Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease

Anna Ryan Hemnes, Jane A. Leopold, Milena Radeva, Gerald J. Beck et autres

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Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation

Yingnan Li, Yong He, Isabelle D. Falzon, Brayden Fairbourn et autres

The nonmaturation rate of arteriovenous fistulas (AVFs) is high.1 The direct connection of the AVF vein and artery creates a short path that bypasses the distal high-resistance vasculature, resulting in an immediate increase in the flow rate and venous pressure. With the …

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Surgical lymph node assessment influences adjuvant therapy in clinically apparent stage I endometrioid endometrial carcinoma, meeting Mayo criteria for lymphadenectomy

Adam Pendlebury, Milena Radeva, Peter Graham Rose

OBJECTIVE: To evaluate the impact of surgical lymph node assessment for clinically apparent, stage I endometrioid endometrial adenocarcinoma meeting Mayo criteria for lymphadenectomy. METHODS: Patients with endometrioid endometrial adenocarcinoma meeting Mayo criteria for lymphadenectomy who underwent hysterectomy and lymphadenectomy were identified. Algorithms …

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Abstract 15029: Atrial Arrhythmias and Pulmonary Hypertension Across Wsph Groups

Erika B. Rosenzweig, Milena Radeva, Robert P. Frantz, Paul M. Hassoun et autres

Introduction: Previous reports have shown that atrial and ventricular arrhythmias (VA) are common in all forms of pulmonary hypertension (PH) with prevalence of supraventricular arrhythmias ranging from 13-25% and VA 27%. Arrhythmias are also associated with clinical worsening events. Reports have limited …

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