Masahito Yamada

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

Gábor G. Kovács, Isidró Ferrer, Irina Alafuzoff, Johannes Attems et autres

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and …

[Alpha-Synuclein in blood and cerebrospinal fluid of patients with alpha-synucleinopathy].

Kenjiro Ono, Masahito Yamada

Alpha-Synuclein protein(alphaS) aggregates from a monomer to assemblies such as oligomers, protofibrils, and mature fibrils. The early intermediate aggregate, that is, the oligomer, has been reported to be the most toxic species. We recently reported that melatonin inhibits alphaS aggregation, including protofibril …

Safety and pharmacokinetics of PF-04360365 following a single-dose intravenous infusion in Japanese subjects with mild-to-moderate Alzheimer’s disease: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation study

Izuru Miyoshi, Yoko Fujimoto, Masahito Yamada, Sadahiro Abe et autres

OBJECTIVE: PF-04360365 is a humanized IgG(2)Δa anti-amyloid β (Aβ) antibody designed to improve outcome in Alzheimer's disease (AD). Single doses of 0.1 - 10 mg/kg were safe and well tolerated in Western (mostly Caucasian) subjects with mild-to-moderate AD. This Phase 1, multicenter, …

Idiopathic sphenoidal defects detected by 3D computed tomography

Ayumi Hamaguchi, Ryoichi Takahashi, Kazuo Iwasa, Masahito Yamada

Idiopathic sphenoidal defects detected by 3D computed tomographyA 38-year-old man with pneumococcal meningitis, pneumocephalus, and CSF rhinorrhea was admitted to our hospital.The CSF rhinorrhea had no traumatic or iatrogenic etiology.The patient was treated with meropenem and recovered from meningitis.Axial plain CT showed …

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Basiparallel Anatomic Scanning–Magnetic Resonance Imaging in Vertebral Artery Dissection

Tsuyoshi Hamaguchi, Masahito Yamada

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The Crow-Fukase (POEMS) Syndrome with Vasospastic Angina

Masahito Yamada, Masanaga Yamawaki, Makoto Michikawa, Noriyoshi Kameda et autres

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Announcement

Gerhard F. Hamann, E. Isenberg, M. Strittmatter, M. Stoll et autres

Primary spinal intramedullary lymphoma mimicking ependymoma

Tomohiko Machiya, Mitsuhiro Yoshita, Kazuo Iwasa, Masahito Yamada

A 60-year-old woman presented to our hospital with a 1-month history of sensory disturbance in the bilateral lower limbs.Neurologic examination demonstrated reduced vibratory and proprioceptive sensation and mild weakness in the bilateral lower limbs.Cervical MRI disclosed a solid intramedullary mass lesion with …

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Subject Index Vol. 57, 2007

Kazuo Iwasa, Daisuke Haga, Tsuyoshi Hamaguchi, Masafumi Uchino et autres

Contents Vol. 57, 2007

Kazuo Iwasa, Daisuke Haga, Tsuyoshi Hamaguchi, Masafumi Uchino et autres

Allodynia in the flank after thalamic stroke

Mitsuhiro Yoshita, Masahito Yamada

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MRI of segmental zoster paresis

Miharu Samuraki, Mitsuhiro Yoshita, Masahito Yamada

Background: Estimates of risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with some antiepileptic drugs (AEDs) have used denominators based on the number of prescriptions or daily doses.Because the risk of SJS is highest in new users of drugs, …