Kathleen Hanlon

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Faye Cole-Sinclair et autres

Flat Colorectal Cancers Are Genetically Determined and Progress to Invasion without Going through a Polypoid Stage

Joshua M. Uronis, Hans H. Herfarth, Tara C. Rubinas, Anika C Bissahoyo et autres

Growing evidence suggests that flat colorectal cancers (CRC) account for 10% to 20% of all CRCs and that these are frequently associated with more advanced pathologies. However, controversy exists as to the origin and progression of flat CRCs compared with the more …

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Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initiator and Promoter in Mice: Effects of Dose, Route, and Diet

Anika C Bissahoyo, Robert Scott Pearsall, Kathleen Hanlon, Vicky Amann et autres

The azoxymethane (AOM) model has been widely used to investigate the pathology and genetics of colorectal cancer in rodents. However, there has been wide variation in treatment regimes, making it difficult to compare across studies. Consequently, standardizing AOM treatment and identifying sources …

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