Zhao‐Qian Teng

Histone Modifications and Chromatin Landscapes in Microglial Function: Developmental Imprinting and Disease-Associated Reprogramming

Xiao Li, Guo Rong-liang, Zhao‐Qian Teng, Pei-Pei Liu et autres

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Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming

Chun-Hui Duan, Pi Liu, X X Sun, Wen-Hui Ma et autres

Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare and severe encephalopathy linked to neurodevelopmental disorders, yet the connection between metabolic dysfunction and impaired neurogenesis remains unclear. In this study, we demonstrate that the loss of Echs1 in neural stem/progenitor cells …

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Targeting FBXO48 with BC1618 promotes axon regeneration and alleviates symptoms of Parkinson’s disease

Sun Yong-quan, Pi Liu, Chang-Ping Li, Zhen-Gang Liu et autres

Introduction Neurons depend on the ubiquitin system to maintain proteostasis, which plays crucial roles in processes of neuronal death and axon regeneration after injuries and diseases. Developing druggable targets within the ubiquitin system that simultaneously support neuroprotection and axon regeneration has been …

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Author Correction: CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord

Shuhui Sun, Li J, S P Wang, Jie Ren et autres

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Nose-to-Brain Delivery of mRNA-Loaded Lipid Nanoparticles Bypasses the Blood–Brain Barrier for Effective Brain Disease Therapy

X H Yu, Xiao-Meng Deng, Yi Lin, Hongyu Ren et autres

mRNA-loaded lipid nanoparticles (mRNA-LNPs) show great therapeutic potential, but their use in central nervous system (CNS) disorders is limited by poor blood–brain barrier (BBB) penetration. Intranasal (IN) administration can bypass the BBB via olfactory/trigeminal pathways, enabling direct brain targeting and rapid screening …

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Requirements for Human Cerebral Organoids

Yan Xu, Chun‐Hui Duan, Tie‐Shan Tang, Yu‐Kai Wang et autres

The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1: cpr70201-sup-0001-Supinfo.docx. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any …

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Integrative transcriptomic analysis reveals oligodendrocyte lineage switching in multiple sclerosis

Zhong-Ze Yan, Pei‐Pei Liu, Hong‐Zhen Du, Guoliang Chai et autres

Multiple sclerosis (MS) is a chronic disease of the central nervous system. The occurrence of MS is a phased process while its cause is still unclear. Here, by combining white matter single-nucleus transcriptomic datasets from MS and control samples, we found molecular …

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Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease

Jing Liu, Zhimeng Wang, Wenwen Liang, Zhenhao Zhang et autres

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Preserving blood-retinal barrier integrity: a path to retinal ganglion cell protection in glaucoma and traumatic optic neuropathy

Lai-Yang Zhou, Zhen-Gang Liu, Sun Yong-quan, Yanzhong Li et autres

Retinal ganglion cells (RGCs) are the visual gateway of the brain, with their axons converging to form the optic nerve, making them the most vulnerable target in diseases such as glaucoma and traumatic optic neuropathy (TON). In both diseases, the disruption of …

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Single‐Cell RNA Sequencing Uncovers Molecular Features Underlying the Disrupted Neurogenesis Following Traumatic Brain Injury

Cong Liu, Fanghong Shao, Xuan‐Cheng He, Hong‐Zhen Du et autres

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with limited effective treatment strategies. Endogenous neural stem cells (NSCs) give rise to neurons and glial cells throughout life. However, NSCs are more likely to differentiate into glial cells …

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Marcks overexpression in retinal ganglion cells promotes optic nerve regeneration

Xue-Qi Peng, Yanzhong Li, Chen Gu, Xuan‐Cheng He et autres

Regeneration of injured central nervous system (CNS) axons is highly restricted, leading to permanent neurological deficits. The myristoylated alanine-rich C-kinase substrate (MARCKS) is a membrane-associated protein kinase C (PKC) substrate ubiquitously expressed in eukaryotic cells, plays critical roles in development, brain plasticity, …

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An EED/PRC2‐H19 Loop Regulates Cerebellar Development

Peipei Liu, Xiao Han, Xiao Li, Shang‐Kun Dai et autres

EED (embryonic ectoderm development) is a core subunit of the polycomb repressive complex 2 (PRC2), which senses the trimethylation of histone H3 lysine 27 (H3K27). However, its biological function in cerebellar development remains unknown. Here, we show that EED deletion from neural …

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