Patrick D. Rowan

A model to predict participant retention in longitudinal acute pancreatitis studies

Ila Lahooti, Lydia Noh, Melica Nikahd, Kathleen L. Tong et autres

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Su1536: DISEASE-RELATED PARAMETERS DO NOT EXPLAIN HALF THE STORY A PROGNOSTIC MODEL TO PREDICT LENGTH OF STAY IN ACUTE PANCREATITIS PERFORMS POORLY

Peter Lee, Daniel Wang, Stacey Culp, James Leonard Buxbaum et autres

A Tensionable and Retensionable Knotless Anchor Repair Construct for Compression After Reduction of Tibial Avulsion Fracture of Anterior Cruciate Ligament

Colby L. Barber, Nicholas A. Ott, Patrick D. Rowan, Louis M. Day et autres

Tibial avulsion fractures comprise a subset of anterior cruciate ligament injuries. Primary fixation methods have traditionally used either screw or suture fixation. New anchor and suture technologies have led to the development of tensionable and retensionable techniques. These newer techniques allow for …

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Knotless Suture Anchors: A Comparative Biomechanical Study of Acetabular Rim Anchor Fixation with Implications for Hip Labral Repair

Patrick D. Rowan, James L. Cook, Will A. Bezold, Nathan W.M. Skelley

Abstract The purpose of this study was to analyze relevant initial-implantation biomechanical properties of five knotless suture anchors available for use in acetabular labral repair. Five knotless suture anchor constructs were tested: Arthrex PushLock 2.9, Arthrex PushLock 2.4, Arthrex SutureTak 3.0, Stryker …

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Adoption of Intramedullary Nail Fixation for Proximal Humerus Fractures: Assessment of Surgical Efficiency and Complications.

Brent Andrew Ponce, Johnathan F. Williams, Shawna L. Watson, Jorge Lopez Perez et autres

Fixation of proximal humerus fractures (PHFs) with intramedullary (IM) nails potentially is a newer, less invasive technique. The purpose of this study was to report on the early adoption results of IM nail use for PHF. Retrospective chart reviews were performed on …

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2019

Brent Andrew Ponce, Johnathan F. Williams, Shawna L. Watson, Jorge Luis Arias Pérez et autres

Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells

Juan Li, Qianying Pan, Patrick D. Rowan, Timothy N. Trotter et autres

// Juan Li 1, 2, * , Qianying Pan 1, 2, * , Patrick D. Rowan 1, * , Timothy N. Trotter 1 , Deniz Peker 1 , Kellie M. Regal 1 , Amjad Javed 3, 4 , Larry J. Suva 5 …

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Abstract 2387: Pre-adipocytes promote myeloma homing to and growth in bone by secretion of soluble molecules

Timothy N. Trotter, Patrick D. Rowan, Qianying Pan, Yang Yang

Abstract Multiple myeloma (MM) is a hematologic malignancy of plasma cells that thrives in and metastasizes throughout the bone marrow microenvironment. This microenvironment is host to a variety of cell types, including osteoblasts, osteoclasts and stromal cells, that become altered both at …

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Abstract 4102: The involvement of EMT in heparanase promoted bone-metastasis in multiple myeloma

Qianying Pan, Juan Li, Patrick D. Rowan, Timothy N. Trotter et autres

Abstract Multiple myeloma (MM), a hematologic malignancy, preferentially grows in bone marrow and frequently metastasizes between bones. Our previous studies have demonstrated that heparanase (HPSE), an enzyme overexpressed in MM cells, promotes MM bone-metastasis and progression. However, the mechanism of HPSE action …

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Myeloma cell–derived Runx2 promotes myeloma progression in bone

Timothy N. Trotter, Mei Li, Qianying Pan, Deniz Peker et autres

The progression of multiple myeloma (MM) is governed by a network of molecular signals, the majority of which remain to be identified. Recent studies suggest that Runt-related transcription factor 2 (Runx2), a well-known bone-specific transcription factor, is also expressed in solid tumors, …

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Myeloma Cell-Derived Runx2 Promotes Myeloma Progression and Bone-Homing

Mei Li, Timothy N. Trotter, Deniz Peker, Patrick D. Rowan et autres

Abstract Background. Multiple myeloma (MM), an incurable plasma-cell malignancy, preferentially grows in bone marrow and frequently metastasizes to new bone sites. The molecular network responsible for progression and bone-metastasis of MM remains largely unknown. Recent work from our laboratory suggests that the …

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Heparanase Promotes Myeloma Metastasis By Inducing EMT-like Features in Both Myeloma Cells and Endothelial Cells

Qianying Pan, Patrick D. Rowan, Racquel D. Innis-Shelton, Timothy N. Trotter et autres

Abstract Background. Bone metastases occur in 80% of patients with multiple myeloma (MM) and are a major cause of patient mortality. We previously demonstrated that MM cell-derived heparanase (HPSE), an enzyme that cleaves heparan sulfate chains, is a master regulator of MM …

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