Christos Paliouras

HSD15 Investigating the Impact of Early Versus Late Diagnosis in Fabry Disease on Healthcare Resource Utilization and Associated Costs in Greece

P. Naoum, Aris Anastasakis, Evangelia Dounousi, Michael D. Hill et autres

Tubulointerstitial Nephritis and Uveitis Syndrome: A Report of 6 Cases with Renal Biopsy and Electron Microscopy Evaluation

Kostas Palamaris, Kostas Stylianou, Maria Destouni, Anastasios Stofas et autres

Tubulointerstitial nephritis with uveitis syndrome is a rare, immune-mediated entity, characterized by oculo-renal inflammation. Diagnosis requires the exclusion of all other causes of tubulointerstitial nephritis (TIN). We present 6 patients with clinical, laboratory, and renal biopsy findings denotative of tubulointerstitial nephritis with …

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#6543 TUBULOINTERSTITIAL NEPHRITIS AND UVEITIS (TINU) SYNDROME: A REPORT OF 6 CASES WITH RENAL BIOPSY AND ELECTRON MICROSCOPY EVALUATION.

Kostas Palamaris, Ioannis Petrakis, Kleio Dermitzaki, Christos Pleros et autres

Abstract Background and Aims Tubulointerstitial nephritis with uveitis (TINU) syndrome is a rare, but probably under-diagnosed, immune-mediated clinical entity, characterized by simultaneous renal and ocular manifestations Diagnosis requires exclusion of all other causes of tubulointerstitial nephritis (TIN). We present six patients with …

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Novel and Founder Pathogenic Variants in X-Linked Alport Syndrome Families in Greece

Despina Hadjipanagi, Gregory Papagregoriou, Constantina Koutsofti, Christiana Polydorou et autres

Alport syndrome (AS) is the most frequent monogenic inherited glomerulopathy and is also genetically and clinically heterogeneous. It is caused by semi-dominant pathogenic variants in the X-linked COL4A5 (NM_000495.5) gene or recessive variants in the COL4A3/COL4A4 (NM_000091.4/NM_000092.4) genes. The disease manifests in …

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Immunosuppressive regimens based on Cyclophospamide or Calcineurin inhibitors: Comparison of their effect in the long term outcome of Primary Membranous Nephropathy

Μaria Stangou, Smaragdi Marinaki, Evangelos Papachristou, Kyriaki Kolovou et autres

INTRODUCTION: Management of the Primary Membranous Nephropathy (PMN) usually involves administration of immunosuppressives. Cyclophosphamide (Cyclo) and Calcineurin Inhibitors (CNIs) are both widely used but only limited data exist to compare their efficacy in long term follow-up. AIM: The aim of the present …

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Histological grading in primary membranous nephropathy is essential for clinical management and predicts outcome of patients

Μaria Stangou, Smaragdi Marinaki, Evangelos Papachristou, George Liapis et autres

AIMS: Diagnosis of primary membranous nephropathy (PMN) is mainly based on immunofluorescence/immunohistochemistry findings. However, assessment of specific features on optical microscopy can help to estimate the severity of the disease, guide treatment and predict the response. The aim of this study was …

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Immunosuppressive regimens based on Cyclophospamide or Calcineurin inhibitors: Comparison of their effect in the long term outcome of Primary Membranous Nephropathy

Μaria Stangou, Smaragdi Marinaki, Evangelos Papachristou, Chrysanthi Kolovou et autres

Abstract Management of the Primary Membranous Nephropathy (PMN) usually involves administration of immunosuppressives. Cyclophosphamide (Cyclo) and Calcineurin Inhibitors (CNIs) are both widely used but only limited data exist to compare their efficacy in long term follow-up. Aim of the present study was …

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Frequent COL4 mutations in familial microhematuria accompanied by later‐onset Alport nephropathy due to focal segmental glomerulosclerosis

L. Papazachariou, Gregory Papagregoriou, Despina Hadjipanagi, Panayiota Demosthenous et autres

Familial microscopic hematuria (FMH) is associated with a genetically heterogeneous group of conditions including the collagen-IV nephropathies, the heritable C3/CFHR5 nephropathy and the glomerulopathy with fibronectin deposits. The clinical course varies widely, ranging from isolated benign familial hematuria to end-stage renal disease …

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Control of proteinuria with increased doses of agalsidase alfa in a patient with Fabry disease with atypical genotype–phenotype expression

Christos Paliouras, Georgios Aperis, Foteini Lamprianou, Giorgos Ntetskas et autres

Fabry disease is a rare X-linked lysosomal storage disorder of glycosphingolipids, caused by the partial or complete deficiency of the lysosomal enzyme alpha-galactosidase A (a-Gal A). The missense mutation pN215S usually causes a milder form of the disease with isolated cardiac involvement. …

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Control of proteinuria with increased doses of agalsidase alfa in a patient with Fabry disease with atypical genotype–phenotype expression

Christos Paliouras, Georgios Aperis, Foteini Lamprianou, Giorgos Ntetskas et autres

Fabry disease is a rare X-linked lysosomal storage disorder of glycosphingolipids, caused by the partial or complete deficiency of the lysosomal enzyme alpha-galactosidase A (a-Gal A). The missense mutation pN215S usually causes a milder form of the disease with isolated cardiac involvement. …

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FP682FAVORABLE EFFECT OF PARICALCITOL ON ERYTHROPOIESIS IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS TREATMENT

Christos Paliouras, Polichronis Alivanis, Ploumis Passadakis

Introduction and Aims: Anemia is a frequent complication of chronic kidney disease. Administration of active vitamin D in patients undergoing chronic hemodialysis has led to improvement of anemia in previous studies. Paricalcitol is a third-generation analogue of vitamin D acting selectively on …

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Membranoproliferative Glomerulonephritis Type 1 Secondary to an Infected Ventriculoperitoneal Shunt: a Case Report

Christos Paliouras, Foteini Lamprianou, Georgios Ntetskas, Georgios Mattas et autres

Abstract Ventricular shunting is the usual method for treatment of congenital or acquired hydrocephalus. Immune-mediated glomerulonephritis (shunt nephritis) is a rare but life-threatening complication of this neurosurgical technique. Intraglomerular deposition of circulating immune complexes and the subsequent activation of the classical pathway …

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