Maria Garofalo

Development and characterization of 3D spinal cord organoids to advance the study of amyotrophic lateral sclerosis

Matteo Bordoni, Eveljn Scarian, Letizia Messa, Maria Garofalo et autres

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Whole transcriptome analysis of unmutated sporadic ALS patients' peripheral blood reveals phenotype-specific gene expression signature

Francesca Dragoni, Maria Garofalo, Rosalinda Di Gerlando, Bartolo Rizzo et autres

Amyotrophic lateral sclerosis (ALS) is an adult neurodegenerative disorder. According to clinical criteria, ALS patients can be classified into eight subgroups: classic, bulbar, pyramidal, pure lower motor neuron, flail arm, pure upper motor neuron, flail leg, and respiratory. There are no well-established …

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A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer’s Disease

Riccardo Rocco Ferrari, Valentina Fantini, Maria Garofalo, Rosalinda Di Gerlando et autres

Alzheimer's disease (AD) is a neurodegenerative disorder that progressively involves brain regions with an often-predictable pattern. Damage to the brain appears to spread and worsen with time, but the molecular mechanisms underlying the region-specific distribution of AD pathology at different stages of …

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HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape

Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni et autres

BACKGROUND: Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dynamics. Despite HDAC6's potential therapeutic value, its exact role in gene regulation and …

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RNA expression profiling in lymphoblastoid cell lines from mutated and non‐mutated amyotrophic lateral sclerosis patients

Jessica Garau, Maria Garofalo, Francesca Dragoni, Eveljn Scarian et autres

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of upper and lower motor neurons with an unknown etiology. The difficulty of recovering biological material from patients led to employ lymphoblastoid cell lines (LCLs) as a model for …

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Extracellular vesicles secreted by cumulus cells contain microRNAs that are potential regulatory factors of mouse oocyte developmental competence

Giulia Fiorentino, Valeria Merico, Mario Zanoni, Sergio Comincini et autres

The role of cumulus cells (CCs) in the acquisition of oocyte developmental competence is not yet fully understood. In a previous study, we matured cumulus-denuded fully-grown mouse oocytes to metaphase II (MII) on a feeder layer of CCs (FL-CCs) isolated from developmentally …

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Abstract 4582: HDAC6 inhibition reshapes the epigenome of cancer via P300 stabilization

Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni et autres

Abstract Introduction: Histone deacetylases (HDACs)are crucial in regulating gene expression, DNA synthesis, and metabolic processes, including cancer, in various cellular environments. The unique structural and functional attributes of class IIb HDAC6 position it as a key player in influencing protein stability and …

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The epigenomic consequences of HDAC6 inactivation reveal a crucial role for P300 suggesting integrated epitherapeutic strategies

Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni et autres

Abstract Background: Histone deacetylases (HDACs) play a pivotal role in gene regulation, DNA synthesis, and cellular metabolism, significantly influencing cancer development. Class IIb histone deacetylase 6 (HDAC6) is crucial in maintaining protein stability and regulating chromatin dynamics, with notable implications in cancer …

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Phenotype-specific gene expression signature in unmutated sALS patients' peripheral blood

Francesca Dragoni, Maria Garofalo, Rosalinda Di Gerlando, Bartolo Rizzo et autres

The database includes the raw data of the article "Phenotype-specific gene expression signature in unmutated sALS patients' peripheral blood". Aim of this work was to define the transcriptomic signature of distinct ALS phenotypes, and to use this information for biomarkers development. We …

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Phenotype-specific gene expression signature in unmutated sALS patients' peripheral blood

Francesca Dragoni, Maria Garofalo, Rosalinda Di Gerlando, Bartolo Rizzo et autres

The database includes the raw data of the article "Phenotype-specific gene expression signature in unmutated sALS patients' peripheral blood". Aim of this work was to define the transcriptomic signature of distinct ALS phenotypes, and to use this information for biomarkers development. We …

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Study of microRNAs and their targets in exosome from Alzheimer’s and Frontotemporal Dementia patients

Rosalinda Di Gerlando, Maria Garofalo, Maria Busacca, Dragoni Francesca et autres

Abstract Background A central role of RNA metabolism and non‐coding RNAs biogenesis has emerged in Alzheimer’s disease (AD) and Frontotemporal Dementia (FTD). We investigated miRNA cargo of Small Extracellular Vesicles (SEVs) derived from plasma of FTD and AD patients, and Healthy Controls …

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Transcriptomic profile across different brain areas in Alzheimer’s disease

Riccardo Rocco Ferrari, Valentina Fantini, Maria Garofalo, Dragoni Francesca et autres

Abstract Background Aging is often characterized by a progressive loss of cognitive abilities due to the onset of Alzheimer Disease (AD). In recent years, ‐omic sciences have allowed us to begin to shed light on its molecular pathways in order to speculate …

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