Sergey S. Nakhodkin

The Evaluation of Significance of Uncoupling Protein Genes UCP1, UCP2, UCP3, UCP4, UCP5, and UCP6 in Human Adaptation to Cold Climates

А.А. Никанорова, Nikolay A. Barashkov, Vera G. Pshennikova, Sergey S. Nakhodkin et autres

Six isoforms of uncoupling proteins (UCPs) exist, spanning from UCP1 to UCP6. A precise physiological function has only been established for UCP1, which is involved in non-shivering thermogenesis, but the functions of other UCPs are still not fully defined. Therefore, the purpose …

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Analysis of Associations of Temperament and Character Traits with Serum Cortisol Levels in Sakha (Yakut) Men Taking Account of Childhood Stress

Sergey S. Nakhodkin, Nikolay A. Barashkov, Anna V. Kazantseva, Vera G. Pshennikova et autres

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Search for environmental factors affecting temperament traits of young people of the Yakut nationality

А. Н. Ноговицына, Sergey S. Nakhodkin, S.S. Kuzmina, Сардана Аркадьевна Федорова

For the first time, study of the influence of environmental factors (place of birth - city/village, season of birth, birth order, number of children in the family, smoking addiction, level of stressful situations experienced) on temperament traits in Yakuts (n=237) was carried …

Analysis of associations of personality traits and stress with the level of serum cortisol in Sakha (Yakut) men

Sergey S. Nakhodkin, Nikolay A. Barashkov, Anna V. Kazantseva, Vera G. Pshennikova et autres

The purpose of this study is to test the hypothesis that personality traits and stressful situations experienced in childhood could be associated with the level of serum cortisol. The sample included 121 healthy adult men of Yakut (Sakha) ethnicity aged 18 to …

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Associations of the AVPR1A RS1 Microsatellite Locus with the Level of Hormones of the Anterior Pituitary Gland and Personality Traits

Sergey S. Nakhodkin, Nikolay A. Barashkov, Anastasiya V. Kazantseva, Vera G. Pshennikova et autres

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Type 2 Thyroid Allostasis in the residents of Yakutia

А.А. Никанорова, Т В Борисова, Vera G. Pshennikova, Sergey S. Nakhodkin et autres

Type 2 thyroid allostasis is a dynamic stress response to changes in thyroid homeostasis that may occur in response to chronic exposure to cold. It is believed that, under these conditions, type 2 allostatic reactions can increase the basal metabolic rate to …

Signs of polar T3 syndrome in young men in Yakutia

А.А. Никанорова, Nikolay A. Barashkov, Vera G. Pshennikova, Sergey S. Nakhodkin et autres

The aim of the study was to search for seasonal variations in the levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) in young men in Yakutia, where there are strong changes in climatic parameters in the winter-spring period …

A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?

А.А. Никанорова, Nikolay A. Barashkov, Vera G. Pshennikova, Fedor M. Teryutin et autres

Thyroid hormones play a crucial role in regulating normal development, growth, and metabolic function. However, the controversy surrounding seasonal changes in free triiodothyronine (FT3) levels remains unresolved. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of …

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Association of the PTGS2 polymorphism rs689466 with plasma irisin level in residents of Yakutia

А.А. Никанорова, Nikolay A. Barashkov, Vera G. Pshennikova, Sergey S. Nakhodkin et autres

Prostaglandin E2 may be involved in an increase in body temperature during cold stress by the type of fever. At the same time, a significant part of heat production is produced during shivering thermogenesis, due to arbitrary muscle activity, which is accompanied …

Relationship of personality traits and stress with functioning of the hypothalamic-pituitary-adrenal axis

Sergey S. Nakhodkin, Nikolay A. Barashkov, Anastasiya V. Kazantseva, Vera G. Pshennikova et autres

The aim of this study is to test the hypothesis that personality traits (neuroticism, extraversion/ introversion) and stressful life events in childhood could be related to HPA axis reactivity. We studied 121 healthy adult men of Yakut ethnicity aged 18–25 years. High …

The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia

А.А. Никанорова, Nikolay A. Barashkov, Vera G. Pshennikova, Sergey S. Nakhodkin et autres

Leptin plays an important role in thermoregulation and is possibly associated with the microevolutionary processes of human adaptation to a cold climate. In this study, based on the Yakut population (n = 281 individuals) living in the coldest region of Siberia (t°minimum …

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Testosterone levels and body mass index in young people in Yakutia

А.А. Никанорова, Nikolay A. Barashkov, Sergey S. Nakhodkin, Vera G. Pshennikova et autres

The purpose of this study was to assess the levels of testosterone in the blood serum depending on the body mass index (BMI) in young men in Yakutia. It was found that in overweight individuals, testosterone levels were significantly lower, compared with …