Michael Clearfield

Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials

Christina Reith, Lisa Blackwell, Jonathan R Emberson, David Preiss et autres

BACKGROUND: Statin product labels (eg, Summaries of Product Characteristics [SmPCs]) list certain adverse outcomes as potential treatment-related effects based mainly on non-randomised and non-blinded studies, which might be subject to bias. We aimed to assess the evidence for such undesirable effects more …

Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Christina Reith, David Preiss, Lisa Blackwell, Jonathan Emberson et autres

Background Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address …

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Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

Christina Reith, Colin Baigent, Lisa Blackwell, Jonathan Emberson et autres

BACKGROUND: Statin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis …

Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

Jane Armitage, Colin Baigent, Elizabeth H Barnes, D. J. Betteridge et autres

Background Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin …

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

Paul M. Ridker, Brendan M. Everett, Aruna D. Pradhan, Jean MacFadyen et autres

BACKGROUND: Inflammation is causally related to atherothrombosis. Treatment with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin-1β, resulted in a lower rate of cardiovascular events than placebo in a previous randomized trial. We sought to determine whether an alternative approach …

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Moving Down the Road Less Traveled: The GROUPIE Program at Touro California

Michael Clearfield

In addition to determining whether elements are met and the COM is compliant with all standards, the COCA may make any of the following accreditation decisions: Accreditation with Exceptional Outcome: This indicates that the COM is in compliance with all standards and …

Public Health and Interprofessional Education as Critical Components in the Evolution of Osteopathic Medical Education

Héctor Eduardo Velasco-Mondragón, Teresita Menini, Catherine West, Michael Clearfield

Public health and interprofessional education (IPE) are included among the osteopathic core competencies and Entrustable Professional Activities that should be reflected in osteopathic medical curricula. Cognizant of the importance of these 2 areas, Touro University College of Osteopathic Medicine-CA (TUCOM) has developed …

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Cardiovascular Disease as a Result of the Interactions Between Obesity, Climate Change, and Inflammation: The COCCI Syndemic

Michael Clearfield, Glenn E. Davis, Jennifer A. Weis, Gregory G. Gayer et autres

Obesity and climate change conspire to create an environment in which subclinical vascular inflammation leads to progressive atherosclerosis, which contributes to the number 1 cause of global mortality: cardiovascular disease. The syndemic model requires 2 or more diseases or contributors to disease …

Fundamentals for an Osteopathic Obesity Designed Study: The Effects of Education on Osteopathic Medical Students’ Attitudes Regarding Obesity

Gregory G. Gayer, Jennifer M. Weiss, Michael Clearfield

CONTEXT: Obesity is a major health concern in the United States, and its prevalence continues to rise. Although it is a common health issue, many people, including health care professionals, are biased against people with obesity. OBJECTIVE: To determine whether a comprehensive …

Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases?

Jean‐Marc Schwarz, Michael Clearfield, Kathleen Mulligan

Epidemiologic studies suggest a link between excess sugar consumption and obesity, fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus. One important pathway that may link these metabolic diseases to sugar consumption is hepatic conversion of sugar to fat, a process …

A Path to Osteopathic Distinction: The Touro California GROUPIE Program

Michael Clearfield

The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials

David Preiss, Ross T. Campbell, Heather Murray, Ian Ford et autres

AIMS: The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events. METHODS AND RESULTS: We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials …

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