Qitian Mu

EWSR1 as a candidate prognostic indicator in acute myeloid leukemia

Lihui Qian, Pei Zhang, Ting Chen, Ying Chen et autres

Background Ewing sarcoma breakpoint region 1(EWSR1) rearrangements have been repeatedly observed in acute myeloid leukemia (AML). However, the clinical impact of EWSR1 expression is still unclear in AML. Therefore, we explored the prognostic significance of EWSR1 in AML.Methods Bone marrow samples from …

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Timed PD-1 blockade synergizes with IL-7/CCL19 armoring to reverse CAR-T exhaustion in PD-L1-high large B-cell lymphoma

Lixia Sheng, Wen Lei, Winston Duo Wu, Yi Zhang et autres

Abstract CAR-T cell therapy targeting CD19 has transformed the treatment landscape for relapsed or refractory large B-cell lymphoma (R/R LBCL), demonstrating curative potential in select patients. Despite achieving high initial response rates, the durability of CAR-T therapy is often compromised by several …

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Multi-omics profiling of the gut Microbiota–Metabolism–Immunity axis reveals predictive biomarkers of treatment response and survival in diffuse large B-cell lymphoma

Lixia Sheng, Changyu Jin, Huijie Hu, Yanli Lai et autres

Abstract Background The immunometabolic interface between gut microbiota and host immunity has emerged as a critical regulator of systemic malignancies. In diffuse large B-cell lymphoma (DLBCL), this crosstalk remains poorly defined, limiting early-response biomarker development. Using metagenomic, metabolomic, and immunomic analyses, we …

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Dual oncogenic role of RNF220 in AML: linking metabolic rewiring to cell proliferation and immune evasion

Bixia Li, Jiang Shi, Yao Xu, Xiao Yan et autres

Background: Acute myeloid leukemia (AML) remains a clinical challenge with suboptimal long-term survival. While circular RNAs derived from the RNF220 host gene have been implicated in AML pathogenesis, the functional role and regulatory mechanisms of RNF220 itself in AML are poorly understood. …

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NIPA1 depletion in tumor-associated macrophages via IGFBP2/EGFR attenuates acute myeloid leukemia progression and chemoresistance

Shanhao Tang, Lixia Sheng, Qitian Mu, Yi Wang et autres

Acute myeloid leukemia (AML) is an aggressive and heterogenous malignancy, with unsatisfactory clinical outcomes even with very intensive treatment strategies. Previous research has revealed that Prader-Willi/Angelman syndrome 1 (NIPA1) is highly expressed in patients with AML and is negatively correlated with overall …

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Prolactin links psychological stress to psoriasis via a fibroblast-chemokine pathway

Huiyao Ge, Shiyao Zhou, Yu Zhao, Xinwen Zhang et autres

Abstract Psoriasis is a chronic inflammatory skin disease that forms a vicious cycle with psychological stress. Whether and how the hypothalamic-pituitary (HP) axis-mediated neuroendocrine system regulates psoriasis remains obscure. Here, we report elevated levels of the pituitary hormone prolactin (PRL) in both …

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High NUP210 mRNA expression and its role in prognosis of acute myeloid leukemia

An Wu, Liyun Yang, Xiao Yan, Yanli Lai et autres

Acute myeloid leukemia (AML) is the most prevalent type of leukemia in adults, characterized by a complex pathogenesis. The nuclear pore complex is pivotal in the development of various of malignant tumors, including hematological malignancies. While the NUP210 gene is upregulated in …

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CAUSAL RELATIONSHIP BETWEEN HELICOBACTER PYLORI ANTIBODIES AND IMMUNE THROMBOCYTOPENIA: A MENDELIAN RANDOMIZATION STUDY

Yuzhan Chen, Qitian Mu, Guifang Ouyang

Background Previous observational studies have suggested a potential causal relationship between Helicobacter pylori (H. pylori) infection and Immune thrombocytopenia (ITP). However, the evidence for causal inference remains contentious, and the underlying mechanisms require further investigation. In order to delve deeper into the …

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Elevated serum direct bilirubin is predictive of a poor prognosis for primary myelodysplastic syndrome

Ying Chen, Danqing Zhou, Chao Ma, Jie Cao et autres

BACKGROUND: The aim of this study was to assess the prognostic significance of serum direct bilirubin (DBIL) for patients newly diagnosed with myelodysplastic syndromes (MDS). METHODS: The clinical, laboratory, and follow-up data of MDS patients were collected, and the associations of DBIL …

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A rare case of splenic marginal zone lymphoma with MYD88 mutation transformed into diffuse large B-cell lymphoma: case report and literature review

Yuzhan Chen, Ting Chen, Shufang Fan, Qitian Mu et autres

In indolent lymphomas, histological transformation (HT) often results in a poor prognosis and presents a significant challenge in the management of these lymphomas. Previous studies have indicated that MYD88 mutations are associated with transformation in certain haematologic malignancies. We report a rare …

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MicroRNA-138 promotes the progression of multiple myeloma through targeting paired PAX5

Xiao Yan, Keting Wang, Cong Shi, Kaihong Xu et autres

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Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis

Ying Chen, Bixia Li, Tingting Niu, Shujun Yang et autres

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