Mary J. C. Ludlam

The Simons Observatory: forecasted constraints on primordial gravitational waves with the expanded array of Small Aperture Telescopes

Irene Abril-Cabezas, S Adachi, P Ade, A.E Adler et autres

We present updated forecasts for the scientific performance of the degree-scale (0.5 deg FWHM at 93 GHz), deep-field survey to be conducted by the Simons Observatory (SO). By 2027, the SO Small Aperture Telescope (SAT) complement will be doubled from three to …

fr (code pays fourni par la source)

Data from Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

Wěi Li, Bu-Er Wang, Paul Moran, Terry Lipari et autres

Abstract The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated its tumor-promoting activity by use of a mouse orthotopic prostate cancer model. First, we compared the tumor growth of low hepsin-expressing LnCaP-17 …

Supplementary Methods, Tables 1-4, Figures 1-4 from Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

Wěi Li, Bu-Er Wang, Paul Moran, Terry Lipari et autres

Supplementary Methods, Tables 1-4, Figures 1-4 from Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

Supplementary Methods, Tables 1-4, Figures 1-4 from Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

Wěi Li, Bu-Er Wang, Paul Moran, Terry Lipari et autres

Supplementary Methods, Tables 1-4, Figures 1-4 from Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

Data from Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

Wei Li, Bu-Er Wang, Paul Moran, Terry Lipari et autres

Abstract The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated its tumor-promoting activity by use of a mouse orthotopic prostate cancer model. First, we compared the tumor growth of low hepsin-expressing LnCaP-17 …

Cell Segmentation in Images Without Structural Fluorescent Labels

Daniel Zyss, Susana A. Ribeiro, Mary J. C. Ludlam, Thomas Walter et autres

Abstract High-content screening (HCS) provides an excellent tool to understand the mechanism of action of drugs on disease-relevant model systems. Careful selection of fluorescent labels (FLs) is crucial for successful HCS assay development. HCS assays typically comprise (1) FLs containing biological information …

fr, us (code pays fourni par la source)

Cell segmentation in images without structural fluorescent labels

Daniel Zyss, Susana A. Ribeiro, Mary J. C. Ludlam, Thomas Walter et autres

High-content screening (HCS) provides an excellent tool to understand the mechanism of action of drugs on disease-relevant model systems. Careful selection of fluorescent labels (FLs) is crucial for successful HCS assay development. HCS assays typically comprise (a) FLs containing biological information of …

fr, us (code pays fourni par la source)

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

H Zhang, J Chen, Sajid Khan Tahir, Darren C. Phillips et autres

The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target. However, directly inhibiting this target requires the disruption of high-affinity …

us (code pays fourni par la source)

Erratum: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou, Jacob R. Haling, Huifen Chen, Kyung Song et autres

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou, Jacob R. Haling, Huifen Chen, Kyung Song et autres

fr, ch, us, gb (code pays fourni par la source)

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Delphine Mérino, Seong Lin Khaw, Stefan Glaser, Daniel J. Anderson et autres

The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class, navitoclax (ABT-263), have shown promising antitumor efficacy in preclinical and early clinical studies. Although both drugs avidly bind Bcl-2, Bcl-x(L), and Bcl-w in vitro, we find that Bcl-2 is the …

au (code pays fourni par la source)

Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays

Chihunt Wong, Daniel J. Anderson, Erinna F. Lee, W. Douglas Fairlie et autres

Bcl-2 family proteins have important roles in tumor initiation, progression and resistance to therapy. Pro-survival Bcl-2 proteins are regulated by their interactions with pro-death BH3-only proteins making these protein-protein interactions attractive therapeutic targets. Although these interactions have been extensively characterized biochemically, there …

us, au (code pays fourni par la source)