Jiangong Niu

Cost and Complication Profile of Targeted Muscle Reinnervation

Mark S. Shafarenko, Alexander F. Mericli, Jiangong Niu, Hui Zhao et autres

Background: Targeted muscle reinnervation (TMR) has emerged as a potentially effective strategy for the management of chronic limb pain in amputation patients. Despite its increasing adoption, a paucity of data exists regarding the complications and associated costs of TMR versus traditional amputation. …

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A chromosome-level genome assembly of the scaly osman Diptychus maculatus

Jiangong Niu, Yibang Wang, Tao Zhang, Jiangwei Hu et autres

Diptychus maculatus, a rare cold-water cyprinid endemic to the high-altitude river systems of Xinjiang, China, has experienced range contraction and increasing conservation concern. However, the lack of a chromosome-level reference genome has limited downstream studies in conservation genomics and comparative genomics for …

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Real-world treatment patterns and mortality associated with GLP1-RAs in breast cancer patients.

Jasmine Singh Sukumar, Jiangong Niu, Inimfon Jackson, Akshara Singareeka Raghavendra et autres

629 Background: GLP1 Receptor Agonists (GLP1) are widely used for type 2 diabetes (DM2) and obesity in adults. However, data on modern utilization and associated health outcomes, including all-cause mortality, in breast cancer (BC) patients is limited. We evaluated these endpoints in …

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Chromosomal fusions trigger rediploidization of autopolyploid genomes

Chuanshuai Xie, Zitu Ma, Chaowei Zhou, Kexin Ma et autres

Abstract The ancestor of all vertebrates is thought to have undergone autopolyploid whole-genome duplication (WGD) 1,2 , doubling the genetic raw material for evolutionary diversification 3–5 . However, we still do not understand the first steps of rediploidization that followed, required for …

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Intensity of end-of-life cancer (EOL) care in Medicare Advantage (MA) vs Traditional Medicare (TM).

Jenny Jing Xiang, Jiangong Niu, Kerin B. Adelson, Rebecca A. Snyder et autres

309 Background: EOL cancer quality metrics are often considered as indicators of overly intensive cancer management and are used to motivate EOL care de-escalation. However, these metrics assume patients received anticancer treatment at some point during their cancer trajectory—many Medicare enrollees with …

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Association of systemic anticancer treatment (SACT) with end-of-life (EOL) healthcare use among older patients with hematologic malignancies.

Jenny Jing Xiang, Lee Cheng, Maureen Canavan, John Kent Lin et autres

306 Background: The receipt of SACT at EOL is associated with lower quality of life and higher healthcare use. However, research has focused on solid tumors or predates the advent of new drugs, such as immunotherapy (IO) and targeted therapy (TT). Despite …

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Association Between Systemic Anticancer Therapy Administration Near the End of Life With Health Care and Hospice Utilization in Older Adults: A SEER Medicare Analysis of End-of-Life Care Quality

Maureen Canavan, Lee Cheng, Jenny Jing Xiang, John Kent Lin et autres

PURPOSE Use of cytotoxic chemotherapy at end-of-life (EOL) is associated with adverse quality of life, increased health care utilization, and lower hospice rates. Although EOL cytotoxic chemotherapy use has declined in recent years, EOL novel (immunotherapy and targeted therapy) use has increased. …

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Racial and Ethnic Disparities Along the Treatment Cascade Among Medicare Fee-for-Service Beneficiaries With Metastatic Breast, Colorectal, Lung, and Prostate Cancers

John Kent Lin, Jiangong Niu, Sharon Hermes Giordano, Pengxiang Li et autres

PURPOSE This study evaluated racial and ethnic disparities along the treatment cascade for Medicare fee-for-service patients with metastatic breast, colorectal, lung, and prostate cancers and disparities in overall survival by treatment receipt and quantified factors contributing to these disparities. METHODS Medicare fee-for-service …

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Harnessing eDNA technology to identify fish diversity and distribution in the Kashi River, a tributary of the Ili River, Xinjiang, China

Jiangong Niu, Hui Jia, Tao Zhang, Jiangwei Hu et autres

Monitoring species diversity and distribution patterns in remote ecosystems presents significant challenges due to vast geographic coverage, harsh environmental conditions, and the limited availability of traditional survey resources. Environmental DNA (eDNA) technology has been proven to be an effective method for biodiversity …

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Development and validation of a histology-specific natural history model of ovarian cancer

Sayaka Ishizawa, Maryam Eghbali‐Zarch, Renu Sara Nargund, Seyyed Mostafa Mousavi Janbeh Sarayi et autres

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Conditional Survival of Patients With Early‐Stage Non‐Small Cell Lung Cancer Who Undergo Lobectomy, Segmentectomy, or Wedge Resection Using the NCDB

Nathaniel Deboever, Michael Eisenberg, Jiangong Niu, William J. Graber et autres

BACKGROUND AND OBJECTIVES: Randomized clinical trials have shown that sub-lobar resection for clinical stage (cStage) IA non-small cell lung cancer (NSCLC) is non-inferior to lobar resection. We evaluated traditional and conditional survival differences between lobectomy, wedge resection, and segmentectomy in patients with …

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Editor’s Note: Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells

Zhe Chang, Zhongkui Li, Xiaoyan Wang, Ya’an Kang et autres