Qiuyuan Shao

Ratio of extracellular water and body cell mass is associated with coronary artery calcification in peritoneal dialysis patients

Ying Liu, Yan Liang, Yuan Feng, Jing Liu et autres

Background Coronary artery calcification (CAC) is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. The extracellular water to body cell mass ratio (ECW/BCM), as an indicator of nutritional status and fluid overload, is closely associated with the …

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CSF1 inhibits ferroptosis in colorectal cancer cells by autocrine activation of the JAK/STAT3 signaling pathway

Qiuyuan Shao, Xinyi Xu, Xingzhi Han, Zixin Liang et autres

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#2047 Trends in the global, regional, and national burden of diabetic kidney disease from 1990 to 2021: a systematic analysis of the global burden of disease study 2021

Sixiu Liu, Ying Liu, Jing Liu, Qingyan Zhang et autres

Abstract Background and Aims This research depicted the global, regional, and national burden of diabetic kidney disease (DKD) from 1990–2021 to assess its epidemiological patterns and trends, which was vital for healthcare interventions. Method To study DKD epidemiological patterns, a comparative analysis …

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#2049 Exploring the mechanism and clinical validation of mitochondrial dynamics-related genes in membranous nephropathy based on Mendelian randomization study and bioinformatics analysis

Qiuyuan Shao, Nan Li, Min Zhao, Chunming Jiang et autres

Abstract Background and Aims Membranous nephropathy (MN) is a prevalent glomerular disease characterized by immune-mediated damage to the glomerular filtration barrier. Despite extensive research, the interplay between MN and mitochondrial dynamics remains largely unexplored. Recent advances in bioinformatics have opened up new …

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1α, 25-dihydroxyvitamin D3 attenuates tumor necrosis factor-α-induced endothelial cell injury by modulating the tumor necrosis factor-α/nuclear factor kappa-B pathway

Yangyang Xia, Sixiu Liu, Qiuyuan Shao, Yuan Feng et autres

Objective: Cardiovascular (CV) diseases remain the leading cause of death in modern societies, with endothelial dysfunction being the common pathology of CV diseases with various etiologies. Therefore, effectively regulating the function of endothelial cells is considered the key to the future treatment …

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Peritoneal dialysis related peritonitis caused by commensal neisseria species: a retrospective case series

Ying Liu, Yuan Feng, Yanting Yu, Qiuyuan Shao et autres

BACKGROUND: Commensal Neisseria species are increasingly recognized as invasive pathogens. Neisseria peritoneal dialysis (PD) related peritonitis is extremely rare, and its clinical course remains unclear. This study aimed to provide an overview of the clinical characteristics and coutcomes of Neisseria peritonitis. METHODS: …

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Identification Exploring the Mechanism and Clinical Validation of Mitochondrial Dynamics-Related Genes in Membranous Nephropathy Based on Mendelian Randomization Study and Bioinformatics Analysis

Qiuyuan Shao, Huimin Qiu, Min Zhao, Chunming Jiang

Background: Membranous nephropathy (MN), a prevalent glomerular disorder, remains poorly understood in terms of its association with mitochondrial dynamics (MD). This study investigated the mechanistic involvement of mitochondrial dynamics-related genes (MDGs) in the pathogenesis of MN. Methods: Comprehensive bioinformatics analyses—encompassing Mendelian randomization, …

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Clinical efficacy of metagenomic next-generation sequencing for the detection of pathogens in peritoneal dialysis-related peritonitis: a prospective cohort study

Qingyan Zhang, Yuan Feng, Yangyang Xia, Qiuyuan Shao et autres

BACKGROUND: Metagenomic next-generation sequencing (mNGS) has been reported to improve pathogen identification in infectious diseases. This prospective cohort study aimed to explore the etiological diagnostic value of mNGS in peritoneal dialysis (PD)-related peritonitis. METHODS: Patients with PD-related peritonitis were consecutively recruited at …

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Pharmacokinetic Aspects of Hydroxychloroquine and Its Relationship to Efficacy in Immunoglobulin A Nephropathy

Yaotong Shi, Ye Wang, Nan Li, Qiuyuan Shao et autres

Introduction: Hydroxychloroquine (HCQ) is recommended for Chinese patients with immunoglobulin A nephropathy (IgAN). This study aimed to investigate the pharmacokinetics of HCQ in the treatment of IgAN and its relationship with therapeutic efficacy. Methods: This prospective study included 49 IgAN patients treated …

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Early reduction in total cholesterol to high-density lipoprotein cholesterol ratio predicts hydroxychloroquine efficacy in treating IgA nephropathy

Yaotong Shi, Ting Yang, Yuan Feng, Nan Li et autres

Background Hydroxychloroquine (HCQ) effectively improves lipid levels in patients with autoimmune diseases. This study aimed to examine the effect of HCQ on lipid profiles in patients with immunoglobulin A (IgA) nephropathy (IgAN) and determine whether alterations in lipid profiles can predict the …

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Hydroxychloroquine blood concentrations and effects in Chinese patients with IgA nephropathy

Ting Yang, Yaotong Shi, Ye Wang, Yuan Feng et autres

BACKGROUND: Hydroxychloroquine (HCQ) is recommended for Chinese patients with immunoglobulin A nephropathy (IgAN). However, the relationship between HCQ blood concentration and the therapeutic effect for IgAN has not yet been defined. This study investigates the optimal and efficacious range of HCQ blood …

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Kunxian capsule alleviates podocyte injury and proteinuria by inactivating β-catenin in db/db mice

Bo Jin, Jing Liu, Yan Zhu, Jian Guo Lu et autres

Background: Diabetic kidney disease (DKD) remains the primary cause of end-stage renal disease (ESRD) globally, but treatment options are limited. Kunxian capsule (KXC) has been utilized for the treatment of autoimmune diseases and IgA nephropathy in China. However, its effect on DKD …

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