Dayuan Shi

Characteristics of maternal-placental vascular malperfusion and its correlation with neonatal adverse outcomes

Huabo Jiang, Dayuan Shi, Luyao Cai, Yao Zhang et autres

INTRODUCTION: Fetal growth restriction (FGR) is the failure of fetal growth to attain inherent genetic potential owing to a diverse array of factors. Limited studies have investigated the correlation between varying levels of maternal-placental vascular malperfusion (MVM)-type FGR and adverse neonatal outcomes. …

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Integrated transcriptomic analysis and machine learning for characterizing diagnostic biomarkers and immune cell infiltration in fetal growth restriction

Xing Wei, Luyao Cai, Dayuan Shi, Qianqian Sun et autres

Background: Fetal growth restriction (FGR) occurs in 10% of pregnancies worldwide. Placenta dysfunction, as one of the most common causes of FGR, is associated with various poor perinatal outcomes. The main objectives of this study were to screen potential diagnostic biomarkers for …

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Placental DNA methylation analysis of selective fetal growth restriction in monochorionic twins reveals aberrant methylated CYP11A1 gene for fetal growth restriction

Dayuan Shi, Xinyao Zhou, Luyao Cai, Xing Wei et autres

Fetal growth restriction (FGR) is associated with increased susceptibility to perinatal morbidity and mortality. Evidence suggests that epigenetic changes play critical roles in the regulation of fetal growth. We sought to present a comprehensive analysis of the associations between placental DNA methylation …

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Genetics Etiologies Associated with Fetal Growth Restriction

Dayuan Shi, Luyao Cai, Luming Sun

Fetal growth restriction (FGR) is associated with multiple adverse perinatal outcomes, such as increased risk of intrauterine death, neonatal morbidity and mortality, and long-term adverse outcomes. Genetic etiological factors are critical in fetuses with intrauterine growth restriction, including chromosomal abnormalities, copy number …

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A Novel Compound Heterozygous Mutation of FSHR Causes Primary Ovarian Insufficiency

Nan Zhang, Jiawei Xu, Xiao Bao, Feifei Zhao et autres

Abstract Background: Primary ovarian insufficiency, one of the main causes of female infertility, is a heterogeneous disease when it comes to the phenotype and etiology. Familial cases are observed in approximately 10% of patients which indicates a strong genetic component. However, the …

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Association between the quality of inner cell mass and first trimester miscarriage after single blastocyst transfer

Dayuan Shi, Jiawei Xu, Meixiang Zhang, Wenbin Niu et autres

BACKGROUND: The blastocyst morphology provided valuable roles for predicting pregnancy and live birth, but was still not fully understood for evaluating miscarriage. The aim of this study was to explore the association between blastocyst morphologic evaluation and first trimester miscarriage combined with …

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Live births following preimplantation genetic testing for dynamic mutation diseases by karyomapping: a report of three cases

Dayuan Shi, Jiawei Xu, Wenbin Niu, Yidong Liu et autres

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Resetting histone modifications during human parental-to-zygotic transition

Weikun Xia, Jiawei Xu, Guang Yu, Guidong Yao et autres

Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks in human oocytes and early embryos. Unlike that in mouse oocytes, the permissive mark trimethylated histone H3 lysine 4 (H3K4me3) …

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Pregnancy rate following transfer of IVF bovine embryos at different developmental stages

Dayuan Shi, Hai-xiong Huang, Yulong Wei, Ronghua Jiang et autres