Miquel Calvo

Single-cell atlas of transcript usage remodelling in antiviral immune responses across human populations

Ruben Chazarra-Gil, Aida Ripoll-Cladellas, Maria Sopena-Rios, Iris Mestres-Pascual et autres

Abstract Humans exhibit substantial interindividual variation in their immune responses to infection, yet the contribution of transcript usage —the relative abundance of gene isoforms— to this variation remains poorly understood. Here, we generate the first single-cell atlas of transcript usage variation during …

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Assessing environmental exposure to viruses in wastewater treatment plant and swine farm scenarios with next-generation sequencing and occupational risk approaches

Marta Itarte, Miquel Calvo, Lola Martínez-Frago, Cristina Mejías-Molina et autres

Occupational exposure to pathogens can pose health risks. This study investigates the viral exposure of workers in a wastewater treatment plant (WWTP) and a swine farm by analyzing aerosol and surfaces samples. Viral contamination was evaluated using quantitative polymerase chain reaction (qPCR) …

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Assessing Environmental Exposure to Viruses in Wastewater Treatment Plant and Swine Farm Scenarios with Next-generation Sequencing and Occupational Risk Approaches

Marta Itarte, Miquel Calvo, Lola Martínez-Frago, Cristina Mejías-Molina et autres

Target enrichment sequencing of aerosol and surface samples collected from wastewater treatment plant (WWTP) and swine farm scenarios.

es, nl (code pays fourni par la source)

Assessing Environmental Exposure to Viruses in Wastewater Treatment Plant and Swine Farm Scenarios with Next-generation Sequencing and Occupational Risk Approaches

Marta Itarte, Miquel Calvo, Lola Martínez-Frago, Cristina Mejías-Molina et autres

Target enrichment sequencing of aerosol and surface samples collected from wastewater treatment plant (WWTP) and swine farm scenarios.

es, nl (code pays fourni par la source)

Evidence of Imitation in Trained Gorillas (Gorilla gorilla gorilla)

Lara Carrasco, Bárbara Martín‐Maldonado, Miquel Calvo, Montserrat Colell

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A fast non-parametric test of association for multiple traits

Diego Garrido-Martín, Miquel Calvo, Ferrán Reverter, Roderic Guigó

The increasing availability of multidimensional phenotypic data in large cohorts of genotyped individuals requires efficient methods to identify genetic effects on multiple traits. Permutational multivariate analysis of variance (PERMANOVA) offers a powerful non-parametric approach. However, it relies on permutations to assess significance, …

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Multi-trait GWAS of hippocampal subfields (summary statistics)

Diego Garrido-Martín, Ferrán Reverter, Miquel Calvo, Roderic Guigó

Summary statistics of the multi-trait GWAS of hippocampal subfields (UK Biobank dataset) performed with MANTA (through the mvgwas-nf Nextflow pipeline), as described in the publication A fast non-parametric test of association for multiple traits by Garrido-Martín et al. in Genome Biology (https://doi.org/10.1186/s13059‑023‑03076‑8).

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Population-biased sQTL catalog

Diego Garrido-Martín, Ferrán Reverter, Miquel Calvo, Roderic Guigó

Population-biased sQTL catalog generated by sqtlseeker2.int-nf in the GTEx dataset, as described in the publication A fast non-parametric test of association for multiple traits by Garrido-Martín et al. in Genome Biology (https://doi.org/10.1186/s13059‑023‑03076‑8).

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Multi-trait GWAS of hippocampal subfields (summary statistics)

Diego Garrido-Martín, Ferrán Reverter, Miquel Calvo, Roderic Guigó

Summary statistics of the multi-trait GWAS of hippocampal subfields (UK Biobank dataset) performed with MANTA (through the mvgwas-nf Nextflow pipeline), as described in the publication A fast non-parametric test of association for multiple traits by Garrido-Martín et al. in Genome Biology (https://doi.org/10.1186/s13059‑023‑03076‑8).

es (code pays fourni par la source)

Population-biased sQTL catalog

Diego Garrido-Martín, Ferrán Reverter, Miquel Calvo, Roderic Guigó

Population-biased sQTL catalog generated by sqtlseeker2.int-nf in the GTEx dataset, as described in the publication A fast non-parametric test of association for multiple traits by Garrido-Martín et al. in Genome Biology (https://doi.org/10.1186/s13059‑023‑03076‑8).

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manta: Multivariate Asymptotic Non-Parametric Test of Association

Diego Garrido-Martín, Ferrán Reverter, Miquel Calvo, Roderic Guigó

The Multivariate Asymptotic Non-parametric Test of Association (MANTA) enables non-parametric, asymptotic P-value computation for multivariate linear models. MANTA relies on the asymptotic null distribution of the PERMANOVA test statistic. P-values are computed using a highly accurate approximation of the corresponding cumulative distribution …

The landscape of expression and alternative splicing variation across human traits

Raquel García-Pérez, José Miguel Ramírez, Aida Ripoll-Cladellas, Ruben Chazarra-Gil et autres

Understanding the consequences of individual transcriptome variation is fundamental to deciphering human biology and disease. We implement a statistical framework to quantify the contributions of 21 individual traits as drivers of gene expression and alternative splicing variation across 46 human tissues and …

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